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The map label for this gene is adhP

Identifier: 157160954

GI number: 157160954

Start: 1569640

End: 1570650

Strand: Reverse

Name: adhP

Synonym: EcHS_A1563

Alternate gene names: 157160954

Gene position: 1570650-1569640 (Counterclockwise)

Preceding gene: 157160955

Following gene: 157160953

Centisome position: 33.82

GC content: 52.42

Gene sequence:

>1011_bases
ATGAAGGCTGCAGTTGTTACGAAGGATCATCATGTTGACGTTACGTATAAAACACTGCGCTCACTGAAACATGGCGAAGC
CCTGCTGAAAATGGAGTGTTGTGGTGTATGTCATACCGATCTTCATGTTAAGAATGGCGATTTTGGTGACAAAACCGGCG
TAATTCTGGGCCATGAAGGCATCGGTGTGGTGGCAGAAGTGGGTCCAGGTGTCACCTCATTAAAACCAGGCGATCGTGCC
AGCGTGGCGTGGTTCTACGAAGGATGCGGTCATTGCGAATACTGTAACAGTGGTAACGAAACGCTCTGCCGTTCAGTTAA
AAATGCCGGATACAGCGTTGATGGCGGGATGGCGGAAGAGTGCATCGTGGTCGCCGATTACGCGGTAAAAGTGCCAGATG
GTCTGGACTCGGCGGCGGCCAGCAGCATTACCTGTGCGGGAGTCACCACCTACAAAGCCGTTAAGCTGTCAAAAATTCGT
CCAGGGCAGTGGATTGCTATCTACGGTCTTGGCGGTCTGGGTAACCTCGCCCTGCAATACGCGAAGAATGTCTTTAACGC
CAAAGTGATCGCCATTGATGTCAATGATGAGCAGTTAAAACTGGCAACCGAAATGGGCGCAGATTTAGCGATTAACTCAC
ACACCGAAGACGCCGCCAAAATTGTGCAGGAGAAAACTGGTGGCGCTCACGCTGCGGTGGTAACAGCGGTAGCTAAAGCT
GCGTTTAACTCGGCAGTTGATGCTGTCCGTGCAGGCGGTCGTGTTGTGGCTGTCGGTCTACCGCCGGAGTCTATGAGCCT
GGATATCCCACGTCTTGTGCTGGATGGTATTGAAGTGGTCGGTTCGCTGGTCGGCACGCGCCAGGATTTAACTGAAGCCT
TCCAGTTTGCCGCCGAAGGTAAAGTGGTGCCGAAAGTCGCCCTGCGTCCGTTAGCGGACATCAACACCATCTTTACTGAG
ATGGAAGAAGGCAAAATCCGTGGCCGCATGGTGATTGATTTCCGTCACTAA

Upstream 100 bases:

>100_bases
TTCCCTCTCCCTTTTTCAGTTCTCATCCATACTGGGTAGTGGCGAATAAATCTCATTTGCCTCACCTGCTATGCAGAACA
TCATCCGAAAAGGAGGAACT

Downstream 100 bases:

>100_bases
GAGGCCTTTGCTGCGACTGCCATGTTCGGGTCGCAGCATCGCACACTCTCCAACATGAAATGGCTAAATGGATTATTGTT
GCGTAGGAAGGAACAATAAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRH

Sequences:

>Translated_336_residues
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRH
>Mature_336_residues
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRH

Specific function: Preferred specificity is towards 1-propanol

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI34577061, Length=289, Percent_Identity=32.1799307958478, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501933, Length=350, Percent_Identity=29.4285714285714, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4501929, Length=290, Percent_Identity=31.3793103448276, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI262073058, Length=299, Percent_Identity=28.7625418060201, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71743840, Length=301, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI71565154, Length=227, Percent_Identity=32.5991189427313, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71565152, Length=295, Percent_Identity=27.4576271186441, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI156523966, Length=324, Percent_Identity=28.7037037037037, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=320, Percent_Identity=28.125, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI156627571, Length=267, Percent_Identity=28.4644194756554, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=100, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=286, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082401, Length=318, Percent_Identity=27.9874213836478, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787863, Length=269, Percent_Identity=29.7397769516729, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=30.1158301158301, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786518, Length=330, Percent_Identity=26.3636363636364, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=28.2051282051282, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=27.190332326284, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=26.5714285714286, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788075, Length=305, Percent_Identity=25.9016393442623, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=278, Percent_Identity=27.6978417266187, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=227, Percent_Identity=30.8370044052863, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=313, Percent_Identity=37.3801916932907, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17562584, Length=318, Percent_Identity=36.4779874213836, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=37.7777777777778, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17562878, Length=195, Percent_Identity=34.3589743589744, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=254, Percent_Identity=30.3149606299213, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=218, Percent_Identity=31.1926605504587, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=233, Percent_Identity=30.0429184549356, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=31.219512195122, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=36.7647058823529, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6323961, Length=317, Percent_Identity=39.7476340694006, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=36.7469879518072, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=36.1764705882353, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319949, Length=318, Percent_Identity=27.9874213836478, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=315, Percent_Identity=27.3015873015873, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=229, Percent_Identity=32.7510917030568, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=287, Percent_Identity=28.2229965156794, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=287, Percent_Identity=28.2229965156794, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=297, Percent_Identity=24.2424242424242, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=212, Percent_Identity=26.8867924528302, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137530, Length=212, Percent_Identity=30.6603773584906, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=208, Percent_Identity=29.3269230769231, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737895, Length=215, Percent_Identity=30.2325581395349, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADHP_ECOLI (P39451)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   M31532
- PIR:   A64901
- RefSeq:   AP_002101.1
- RefSeq:   NP_415995.4
- ProteinModelPortal:   P39451
- SMR:   P39451
- STRING:   P39451
- EnsemblBacteria:   EBESCT00000004089
- EnsemblBacteria:   EBESCT00000015957
- GeneID:   946036
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1474
- KEGG:   eco:b1478
- EchoBASE:   EB2506
- EcoGene:   EG12622
- eggNOG:   COG1064
- GeneTree:   EBGT00050000008796
- HOGENOM:   HBG753318
- OMA:   VRPGQWI
- ProtClustDB:   PRK09422
- BioCyc:   EcoCyc:ADHP-MONOMER
- BioCyc:   MetaCyc:ADHP-MONOMER
- Genevestigator:   P39451
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.1

Molecular weight: Translated: 35380; Mature: 35380

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEEECCCEEEEHHHHHHHHHCCCCEEEEHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
CIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCHHHCCEEEECCCEEEEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
CCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEEECCCEEEEHHHHHHHHHCCCCEEEEHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
CIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCHHHCCEEEECCCEEEEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
CCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 2158980