Click here to switch to the map view.

The map label for this gene is pgm

Identifier: 157160168

GI number: 157160168

Start: 743912

End: 745552

Strand: Direct

Name: pgm

Synonym: EcHS_A0735

Alternate gene names: 157160168

Gene position: 743912-745552 (Clockwise)

Preceding gene: 157160167

Following gene: 157160170

Centisome position: 16.02

GC content: 55.39

Gene sequence:

>1641_bases
ATGGCAATCCACAATCGTGCAGGCCAACCTGCACAACAGAGTGATTTGATTAACGTCGCCCAACTGACGGCGCAATATTA
TGTACTGAAACCAGAAGCAGGGAATGCGGAGCACGCGGTGAAATTCGGTACTTCCGGTCACCGTGGCAGTGCAGCGCGCC
ACAGCTTTAACGAGCCGCACATTCTGGCGATCGCTCAGGCAATTGCTGAAGAACGTGCGAAAAACGGCATCACTGGCCCT
TGCTATGTGGGTAAAGATACTCACGCCCTGTCCGAGCCTGCGTTCATTTCCGTACTGGAAGTGCTGGCAGCGAACGGCGT
TGATGTCATTGTGCAGGAAAACAATGGCTTCACTCCAACGCCTGCCGTTTCCAATGCCATCCTGGTTCACAATAAAAAAG
GTGGCCCGCTGGCAGACGGTATCGTGATTACACCGTCCCATAACCCGCCGGAAGATGGTGGTATCAAGTACAATCCGCCA
AATGGTGGCCCGGCTGATACCAACGTCACCAAAGTGGTGGAAGACAGGGCCAACGCACTGCTGGCCGATGGCCTGAAAGG
CGTGAAGCGTATCTCCCTCGACGAAGCGATGGCATCCGGTCATGTGAAAGAGCAGGATCTGGTGCAGCCGTTCGTGGAAG
GGCTGGCCGATATCGTTGATATGGCGGCGATTCAGAAAGCGGGCCTGACGCTTGGCGTTGATCCGCTGGGCGGTTCCGGT
ATCGAATACTGGAAGCGTATTGGCGAGTATTACAACCTCAACCTGACTATCGTTAACGATCAGGTCGATCAAACCTTCCG
CTTTATGCACCTTGATAAAGACGGCGCGATCCGTATGGACTGCTCCTCCGAGTGTGCGATGGCGGGCCTGCTGGCACTGC
GTGATAAGTTCGATCTGGCGTTTGCTAACGACCCGGATTATGACCGTCACGGTATCGTCACTCCGGCAGGTTTGATGAAT
CCGAACCACTACCTGGCGGTGGCGATCAATTACCTGTTCCAGCATCGTCCGCAGTGGGGCAAAGATGTTGCCGTTGGTAA
AACGCTGGTTTCTTCTGCGATGATCGACCGTGTGGTCAATGACTTGGGTCGTAAGCTGGTAGAAGTCCCGGTAGGTTTCA
AATGGTTTGTTGATGGTCTGTTCGACGGCAGCTTCGGCTTTGGCGGCGAAGAGAGCGCAGGGGCTTCCTTCCTGCGTTTC
GACGGCACGCCGTGGTCCACCGACAAAGACGGCATCATCATGTGTCTGCTGGCGGCGGAAATCACCGCTGTCACCGGTAA
GAACCCGCAGGAACACTACAACGAACTGGCAAAACGCTTTGGTGCGCCGAGCTACAACCGTTTGCAGGCAGCTGCGACTT
CCGCACAAAAAGCGGCGCTGTCTAAGCTGTCTCCGGAAATGGTGAGCGCCAGCACCCTGGCAGGTGACCCGATCACCGCG
CGCCTGACTGCTGCTCCGGGCAACGGTGCTTCTATTGGCGGTCTGAAAGTGATGACTGACAACGGCTGGTTCGCCGCGCG
TCCGTCAGGCACGGAAGACGCATATAAGATCTACTGCGAAAGCTTCCTCGGTGAAGAACATCGCAAGCAGATCGAGAAAG
AAGCGGTTGAGATTGTTAGCGAAGTTCTGAAAAACGCGTAA

Upstream 100 bases:

>100_bases
AGCATGATCGAACACATCATGCAGTCGATGCAATTCCCGGCGGAATTGATTGAGAAGGTTTGCGGAACTATCTAAAACGT
TGCAGACAAAGGACAAAGCA

Downstream 100 bases:

>100_bases
ACACATTAAATAAGAAAAAGGGCGGTCGGAAGATCGCCCTTTTTTACGTATGACAAACACAGAATTGCCTGATGCGCTAC
GCTTATCAGGCCTACGAGGA

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGP
CYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPP
NGGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMN
PNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRF
DGTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA

Sequences:

>Translated_546_residues
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGP
CYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPP
NGGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMN
PNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRF
DGTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA
>Mature_545_residues
AIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGPC
YVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPN
GGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSGI
EYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMNP
NHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFD
GTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITAR
LTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA

Specific function: This enzyme participates in both the breakdown and synthesis of glucose

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family

Homologues:

Organism=Homo sapiens, GI290463102, Length=447, Percent_Identity=26.3982102908277, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI133922562, Length=420, Percent_Identity=25, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI21361621, Length=399, Percent_Identity=27.0676691729323, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=100, Blast_Score=1126, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535441, Length=567, Percent_Identity=26.1022927689594, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323752, Length=561, Percent_Identity=26.2032085561497, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322722, Length=532, Percent_Identity=27.4436090225564, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17864244, Length=453, Percent_Identity=28.9183222958057, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGM_ECOLI (P36938)

Other databases:

- EMBL:   U08369
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   U07651
- PIR:   G64803
- RefSeq:   AP_001326.1
- RefSeq:   NP_415214.1
- ProteinModelPortal:   P36938
- SMR:   P36938
- DIP:   DIP-10472N
- IntAct:   P36938
- MINT:   MINT-1240111
- STRING:   P36938
- EnsemblBacteria:   EBESCT00000003152
- EnsemblBacteria:   EBESCT00000014420
- GeneID:   945271
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0675
- KEGG:   eco:b0688
- EchoBASE:   EB2065
- EcoGene:   EG12144
- eggNOG:   COG0033
- GeneTree:   EBGT00050000010196
- HOGENOM:   HBG298534
- OMA:   WDGKIRM
- ProtClustDB:   PRK07564
- BioCyc:   EcoCyc:PHOSPHOGLUCMUT-MONOMER
- BioCyc:   MetaCyc:PHOSPHOGLUCMUT-MONOMER
- Genevestigator:   P36938
- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852
- Gene3D:   G3DSA:3.40.120.10
- TIGRFAMs:   TIGR01132

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV; SSF53738 A-D-PHexomutase_a/b/a-I/II/III

EC number: =5.4.2.2

Molecular weight: Translated: 58361; Mature: 58230

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00710 PGM_PMM

Important sites: ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPH
CCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCCCEEEECCCCCCCCHHHCCCCCCH
ILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
PAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANAL
CCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCH
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLA
HHHHHHHCHHEEEEEEEECCCHHHHEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEE
FANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVN
ECCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAE
HHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHH
ITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
HHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVS
EEEECCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EVLKNA
HHHHCC
>Mature Secondary Structure 
AIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPH
CCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCCCEEEECCCCCCCCHHHCCCCCCH
ILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
PAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANAL
CCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCH
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLA
HHHHHHHCHHEEEEEEEECCCHHHHEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEE
FANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVN
ECCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAE
HHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHH
ITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
HHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVS
EEEECCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EVLKNA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018