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The map label for this gene is trpB1 [H]

Identifier: 156937888

GI number: 156937888

Start: 980808

End: 982088

Strand: Direct

Name: trpB1 [H]

Synonym: Igni_1100

Alternate gene names: 156937888

Gene position: 980808-982088 (Clockwise)

Preceding gene: 156937887

Following gene: 156937889

Centisome position: 75.59

GC content: 59.72

Gene sequence:

>1281_bases
GTGGAGCTTCCGAACAAATGGTATAACATACTCCCCGACCTCCCCAAGCCCTTGGCCCCTCCGAGAGACCCCGAGGGGGC
GGAGGAGGAGTTCTCGAGGATAGAGCTGTTGCTAAAGGTGTTGCCACAAAAGCTCATCTGGCAAGAGAACACCGTGGAGC
GCTGGGTCCCCATACCGGACGAGGTGTTGGAGGTTTACAAGGAAATAGGGAGGCCCACCCCCCTCATGAGGGCGAGGAGG
CTGGAGAAGCTCCTAGACACCCCGGCCCGCATTTACTTCAAGTACGAGGGCGCCACCCCCACCGGCAGCCACAAGATAAA
CACTGCCGTCCCACAAGCCTACTACGCTAAGGAGGAGGGAGTGGAGGGCCTCACCACCGAGACCGGGGCCGGCCAGTGGG
GCACGGCCTTGGCCTTGGCCGGCGCGATGTACGACATGCCGGTCAAGGTGTTTATGGTGAGGAGCAGCTACCACCAGAAG
CCCTACCGCAGAGTAATAATGAGGCTCTACGGCGCCGACGTCACCCCCTCGCCCAGCGAGGAGACCGAGTTCGGGAAGAA
GGTGTTGAGGGAGAACCCCGACCACCCCGGAAGCTTGGGGATCGCCATGAGCGAGGCCATAGAATACGCTTTGAAGAGGA
ACTGGAGGTACGGCGTCGGGTCAGTAATGAACTTCGTGCTCCTACACCAATCGATCATAGGCCTCGAGGCCATGAAGCAG
ATGGAGGAGATCGGCGAGGACCCGGACGTGTTAGTGGCTTGCATAGGCGGGGGCTCTAACTTCGGGGGCTTGGTGTTCCC
CTTCTTGGGGCAAGAGCTCCAGAAGACCAAGGACCCCAAGAAGAAGAGGAGGAGGTACGTGGGAGTTACCCCCTCTGAGG
TGCCCAAGTTCAGCAAGGGCAAGTACGAGTACGACTTCGCCGACGCGGCCGGCCTCCTCCCGCAGCTCAAGATGCACACC
TTAGGCCACGAGTTCACCCCGCCCCCCATATACGCGGGGGGACTGAGGTACCACGGGGTGGCCCCGGCCATATCCTTGCT
CTACGAGGAAGGGTGGATCGAAATTATGGAGTACGAACAGAAGGAGTGCTTCGAGGCCGGCAGGCTCTTCGCCAAGGCCG
AGGGAATTGTGCCGGCGCCGGAGACAAACCACGCGATCAAGGCGGTTATAGACCTTGCTTTGGAAGCTAAGAGGAAGAAC
GAAGAGATGGTAATACTCTTCAACTTCAGTGGCCACGGGTTGTTAGACCTGGGCAACTACCAGAGCGTCTTGGGCTTGTG
A

Upstream 100 bases:

>100_bases
GAAGTACTCCGAAGAGGAGGCGCAAGAGGTCGCTAGGAAGATAAGAGAAGCTCTCGGATGATTTTATTTTCCCCAGACCC
CAAGCCTTGGGTAACGAGGA

Downstream 100 bases:

>100_bases
GGGGATGGCCCCGAATGCCGGTGCCTTGTCCCTTCTGCGGAGTGGGGTGCAAGCTCAAGGAGGACGGCAAGCCGTTGGGC
CCGGTGTGCGGCAAGGGGCT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MELPNKWYNILPDLPKPLAPPRDPEGAEEEFSRIELLLKVLPQKLIWQENTVERWVPIPDEVLEVYKEIGRPTPLMRARR
LEKLLDTPARIYFKYEGATPTGSHKINTAVPQAYYAKEEGVEGLTTETGAGQWGTALALAGAMYDMPVKVFMVRSSYHQK
PYRRVIMRLYGADVTPSPSEETEFGKKVLRENPDHPGSLGIAMSEAIEYALKRNWRYGVGSVMNFVLLHQSIIGLEAMKQ
MEEIGEDPDVLVACIGGGSNFGGLVFPFLGQELQKTKDPKKKRRRYVGVTPSEVPKFSKGKYEYDFADAAGLLPQLKMHT
LGHEFTPPPIYAGGLRYHGVAPAISLLYEEGWIEIMEYEQKECFEAGRLFAKAEGIVPAPETNHAIKAVIDLALEAKRKN
EEMVILFNFSGHGLLDLGNYQSVLGL

Sequences:

>Translated_426_residues
MELPNKWYNILPDLPKPLAPPRDPEGAEEEFSRIELLLKVLPQKLIWQENTVERWVPIPDEVLEVYKEIGRPTPLMRARR
LEKLLDTPARIYFKYEGATPTGSHKINTAVPQAYYAKEEGVEGLTTETGAGQWGTALALAGAMYDMPVKVFMVRSSYHQK
PYRRVIMRLYGADVTPSPSEETEFGKKVLRENPDHPGSLGIAMSEAIEYALKRNWRYGVGSVMNFVLLHQSIIGLEAMKQ
MEEIGEDPDVLVACIGGGSNFGGLVFPFLGQELQKTKDPKKKRRRYVGVTPSEVPKFSKGKYEYDFADAAGLLPQLKMHT
LGHEFTPPPIYAGGLRYHGVAPAISLLYEEGWIEIMEYEQKECFEAGRLFAKAEGIVPAPETNHAIKAVIDLALEAKRKN
EEMVILFNFSGHGLLDLGNYQSVLGL
>Mature_426_residues
MELPNKWYNILPDLPKPLAPPRDPEGAEEEFSRIELLLKVLPQKLIWQENTVERWVPIPDEVLEVYKEIGRPTPLMRARR
LEKLLDTPARIYFKYEGATPTGSHKINTAVPQAYYAKEEGVEGLTTETGAGQWGTALALAGAMYDMPVKVFMVRSSYHQK
PYRRVIMRLYGADVTPSPSEETEFGKKVLRENPDHPGSLGIAMSEAIEYALKRNWRYGVGSVMNFVLLHQSIIGLEAMKQ
MEEIGEDPDVLVACIGGGSNFGGLVFPFLGQELQKTKDPKKKRRRYVGVTPSEVPKFSKGKYEYDFADAAGLLPQLKMHT
LGHEFTPPPIYAGGLRYHGVAPAISLLYEEGWIEIMEYEQKECFEAGRLFAKAEGIVPAPETNHAIKAVIDLALEAKRKN
EEMVILFNFSGHGLLDLGNYQSVLGL

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG1350

COG function: function code R; Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=389, Percent_Identity=26.9922879177378, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321412, Length=380, Percent_Identity=30.5263157894737, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006316
- InterPro:   IPR006653
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 47796; Mature: 47796

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPNKWYNILPDLPKPLAPPRDPEGAEEEFSRIELLLKVLPQKLIWQENTVERWVPIPD
CCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCH
EVLEVYKEIGRPTPLMRARRLEKLLDTPARIYFKYEGATPTGSHKINTAVPQAYYAKEEG
HHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHCCHHHHHHHCC
VEGLTTETGAGQWGTALALAGAMYDMPVKVFMVRSSYHQKPYRRVIMRLYGADVTPSPSE
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCH
ETEFGKKVLRENPDHPGSLGIAMSEAIEYALKRNWRYGVGSVMNFVLLHQSIIGLEAMKQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MEEIGEDPDVLVACIGGGSNFGGLVFPFLGQELQKTKDPKKKRRRYVGVTPSEVPKFSKG
HHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHCCCCCCC
KYEYDFADAAGLLPQLKMHTLGHEFTPPPIYAGGLRYHGVAPAISLLYEEGWIEIMEYEQ
CEEECHHHHHHHHHHHHHHHCCCCCCCCCCEECCEECCCHHHHHHHHHHCCHHHHHHHHH
KECFEAGRLFAKAEGIVPAPETNHAIKAVIDLALEAKRKNEEMVILFNFSGHGLLDLGNY
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCC
QSVLGL
HHHHCC
>Mature Secondary Structure
MELPNKWYNILPDLPKPLAPPRDPEGAEEEFSRIELLLKVLPQKLIWQENTVERWVPIPD
CCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCH
EVLEVYKEIGRPTPLMRARRLEKLLDTPARIYFKYEGATPTGSHKINTAVPQAYYAKEEG
HHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHCCHHHHHHHCC
VEGLTTETGAGQWGTALALAGAMYDMPVKVFMVRSSYHQKPYRRVIMRLYGADVTPSPSE
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCH
ETEFGKKVLRENPDHPGSLGIAMSEAIEYALKRNWRYGVGSVMNFVLLHQSIIGLEAMKQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MEEIGEDPDVLVACIGGGSNFGGLVFPFLGQELQKTKDPKKKRRRYVGVTPSEVPKFSKG
HHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHCCCCCCC
KYEYDFADAAGLLPQLKMHTLGHEFTPPPIYAGGLRYHGVAPAISLLYEEGWIEIMEYEQ
CEEECHHHHHHHHHHHHHHHCCCCCCCCCCEECCEECCCHHHHHHHHHHCCHHHHHHHHH
KECFEAGRLFAKAEGIVPAPETNHAIKAVIDLALEAKRKNEEMVILFNFSGHGLLDLGNY
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCC
QSVLGL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]