Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 156937141

GI number: 156937141

Start: 305408

End: 306544

Strand: Reverse

Name: tyrS [H]

Synonym: Igni_0347

Alternate gene names: 156937141

Gene position: 306544-305408 (Counterclockwise)

Preceding gene: 156937147

Following gene: 156937140

Centisome position: 23.63

GC content: 52.95

Gene sequence:

>1137_bases
GTGGACGAGAAGATAAGACTCATCATGAGGGAACCCACCGAGGAAGTGCTCACCCCCGAGCTCCTGAAGGAGTACATAGA
ACAAGGGGTCCCCCTGAAGCACTACATAGGCTTCGAGATCTCCGGCTTCGTACACTTAGGAACCGGAATAGTTACCATGA
GGAAGGTGGCCGACTTACAAAGGGCCGGAGTTAAGACGACCTTGTTTTTGGCAGACTATCACTCGTGGATAAACAAGAAG
CTTGGCGGGGACTTGGACACCATAAAGAGGGTCGCGTTGGGCTACTTCAAGGAGGCCTTGCTCCAGTCCCTAAAGGCCGT
AGGAGGGGACCCGGAGTCCGTGGAGGTAATACTCGCCTCGGAGTTCTTCGAGAAGCTCGGGATTAAGTACTTTGAAAACT
TCTTGAGAGTTTCCAACAGGCTAACGCTAGCTAGGGTAAAGAGGAGCATAACAATAATGGGGAGGAAGGAGGGCGAGTCG
GTGAACTTCGGACAGCTGGTTTACGTGCCAATGCAAGTGGCCGACATATTCTCCCTCGGGGTTAACTTGGCCCACGGCGG
AATGGACCAGAGGAAGGCGCACGTAATAGCAATAGAGGTGGGGCCCAAGGAGTTCGGCTACAAGCCCGTGGCGCTCCACC
ACCACTTGCTACTGGGCCTTCACATAGATGAAGAGACGAGGGAGAAGCTGTTGAAGGCTAAGAGGGAAGGCGATAGAGAG
GCCTTCGAGGAAGGGATAGTTGAAATAAAAATGTCCAAGTCTGTGCCCCAGAGCGCCATATTCGTACACGACTCCCCCGA
GGAGATCAAGAGGAAACTGAAGAGGGCCTACTGTCCTATTGGAGAGGTCGAAATGAACCCGGTGTTGGAAATAGTGAAGT
ACGTGGTGTTCCCTTGGTTGGAGGACTTGGGGAGGAGCTTCGAAGTAGTAAACAAGAAGACGGGAGAGAGGAAGGAGTAC
AAGAGTTATCAAGAGGTGGAAAGGGACTTCGCCGCCAAGGCCTTACACCCGCTGGACCTCAAGTTGGCCGTGGCGGAGTA
CTTGGTTGAGATGCTGAAGCCCGTTAGGGAGTACTTCGTAGAGGGGCCGGGCAAGAAATACCTCGAGGAAATGAAGGAGA
TACAGATAACTAGGTGA

Upstream 100 bases:

>100_bases
TTGCCACCGGCCACCGAGCGACCTTGGAGGTTATAAGCGCTCTAACCCATGAGCTCGTCGATATTAAATTTCGCTTCGCG
CGCGCTCAGGGTAAGGCGAG

Downstream 100 bases:

>100_bases
AGTTTTATATCCTGGACGCGCGAGCGCGCCCACAAGGGTACTTGGGTGCCAGTTAGGCTCGTGGTAGGCGCGCTCTTCGG
GGACGAGGGTAAGGGCAAAG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MDEKIRLIMREPTEEVLTPELLKEYIEQGVPLKHYIGFEISGFVHLGTGIVTMRKVADLQRAGVKTTLFLADYHSWINKK
LGGDLDTIKRVALGYFKEALLQSLKAVGGDPESVEVILASEFFEKLGIKYFENFLRVSNRLTLARVKRSITIMGRKEGES
VNFGQLVYVPMQVADIFSLGVNLAHGGMDQRKAHVIAIEVGPKEFGYKPVALHHHLLLGLHIDEETREKLLKAKREGDRE
AFEEGIVEIKMSKSVPQSAIFVHDSPEEIKRKLKRAYCPIGEVEMNPVLEIVKYVVFPWLEDLGRSFEVVNKKTGERKEY
KSYQEVERDFAAKALHPLDLKLAVAEYLVEMLKPVREYFVEGPGKKYLEEMKEIQITR

Sequences:

>Translated_378_residues
MDEKIRLIMREPTEEVLTPELLKEYIEQGVPLKHYIGFEISGFVHLGTGIVTMRKVADLQRAGVKTTLFLADYHSWINKK
LGGDLDTIKRVALGYFKEALLQSLKAVGGDPESVEVILASEFFEKLGIKYFENFLRVSNRLTLARVKRSITIMGRKEGES
VNFGQLVYVPMQVADIFSLGVNLAHGGMDQRKAHVIAIEVGPKEFGYKPVALHHHLLLGLHIDEETREKLLKAKREGDRE
AFEEGIVEIKMSKSVPQSAIFVHDSPEEIKRKLKRAYCPIGEVEMNPVLEIVKYVVFPWLEDLGRSFEVVNKKTGERKEY
KSYQEVERDFAAKALHPLDLKLAVAEYLVEMLKPVREYFVEGPGKKYLEEMKEIQITR
>Mature_378_residues
MDEKIRLIMREPTEEVLTPELLKEYIEQGVPLKHYIGFEISGFVHLGTGIVTMRKVADLQRAGVKTTLFLADYHSWINKK
LGGDLDTIKRVALGYFKEALLQSLKAVGGDPESVEVILASEFFEKLGIKYFENFLRVSNRLTLARVKRSITIMGRKEGES
VNFGQLVYVPMQVADIFSLGVNLAHGGMDQRKAHVIAIEVGPKEFGYKPVALHHHLLLGLHIDEETREKLLKAKREGDRE
AFEEGIVEIKMSKSVPQSAIFVHDSPEEIKRKLKRAYCPIGEVEMNPVLEIVKYVVFPWLEDLGRSFEVVNKKTGERKEY
KSYQEVERDFAAKALHPLDLKLAVAEYLVEMLKPVREYFVEGPGKKYLEEMKEIQITR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=360, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71992775, Length=359, Percent_Identity=27.2980501392758, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321624, Length=367, Percent_Identity=30.2452316076294, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357223, Length=364, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 43202; Mature: 43202

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKIRLIMREPTEEVLTPELLKEYIEQGVPLKHYIGFEISGFVHLGTGIVTMRKVADLQ
CCCCEEEEECCCHHHHCCHHHHHHHHHCCCCEEHHHCCEEECCEEECHHHHHHHHHHHHH
RAGVKTTLFLADYHSWINKKLGGDLDTIKRVALGYFKEALLQSLKAVGGDPESVEVILAS
HCCCHHEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHH
EFFEKLGIKYFENFLRVSNRLTLARVKRSITIMGRKEGESVNFGQLVYVPMQVADIFSLG
HHHHHHCHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCCCCCEEEEHHHHHHHHHHC
VNLAHGGMDQRKAHVIAIEVGPKEFGYKPVALHHHLLLGLHIDEETREKLLKAKREGDRE
CHHHCCCCCCCCEEEEEEEECHHHHCCCCHHHHHHHHEEEEECHHHHHHHHHHHHCCCHH
AFEEGIVEIKMSKSVPQSAIFVHDSPEEIKRKLKRAYCPIGEVEMNPVLEIVKYVVFPWL
HHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EDLGRSFEVVNKKTGERKEYKSYQEVERDFAAKALHPLDLKLAVAEYLVEMLKPVREYFV
HHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EGPGKKYLEEMKEIQITR
CCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDEKIRLIMREPTEEVLTPELLKEYIEQGVPLKHYIGFEISGFVHLGTGIVTMRKVADLQ
CCCCEEEEECCCHHHHCCHHHHHHHHHCCCCEEHHHCCEEECCEEECHHHHHHHHHHHHH
RAGVKTTLFLADYHSWINKKLGGDLDTIKRVALGYFKEALLQSLKAVGGDPESVEVILAS
HCCCHHEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHH
EFFEKLGIKYFENFLRVSNRLTLARVKRSITIMGRKEGESVNFGQLVYVPMQVADIFSLG
HHHHHHCHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCCCCCEEEEHHHHHHHHHHC
VNLAHGGMDQRKAHVIAIEVGPKEFGYKPVALHHHLLLGLHIDEETREKLLKAKREGDRE
CHHHCCCCCCCCEEEEEEEECHHHHCCCCHHHHHHHHEEEEECHHHHHHHHHHHHCCCHH
AFEEGIVEIKMSKSVPQSAIFVHDSPEEIKRKLKRAYCPIGEVEMNPVLEIVKYVVFPWL
HHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EDLGRSFEVVNKKTGERKEYKSYQEVERDFAAKALHPLDLKLAVAEYLVEMLKPVREYFV
HHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EGPGKKYLEEMKEIQITR
CCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14566062 [H]