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The map label for this gene is htrA [H]

Identifier: 15675945

GI number: 15675945

Start: 1850352

End: 1851575

Strand: Direct

Name: htrA [H]

Synonym: SPy_2216

Alternate gene names: 15675945

Gene position: 1850352-1851575 (Clockwise)

Preceding gene: 15675943

Following gene: 15675946

Centisome position: 99.89

GC content: 34.4

Gene sequence:

>1224_bases
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCATCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGAATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGTCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Upstream 100 bases:

>100_bases
AGTAATCCACAGGCTGTGGATTACTTTTCTTTTTTTTATTTTTAAGGTATAATTAAGCAAAGTTCTATAAGCTATGGACA
AATAATTCGGAGGACAAAAC

Downstream 100 bases:

>100_bases
ACAAGCTACCTAAATACTATTACATTTTATCACATAAAACAGTCCAAAGGACTGTTTTATGTTTCTTATTCTATCCAGGA
ACTCCCTTATGACAAAAGAA

Product: putative serine protease

Products: NA

Alternate protein names: HtrALl [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Sequences:

>Translated_407_residues
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ
>Mature_406_residues
PSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSSS
LSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLAV
VKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNSG
GPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQI
NIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTTQ
DLTKTQ

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=289, Percent_Identity=32.1799307958478, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI4506141, Length=268, Percent_Identity=32.8358208955224, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=31.8840579710145, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI7019477, Length=273, Percent_Identity=30.03663003663, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1786356, Length=294, Percent_Identity=37.0748299319728, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789629, Length=331, Percent_Identity=36.2537764350453, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789630, Length=366, Percent_Identity=32.7868852459016, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24646839, Length=307, Percent_Identity=31.5960912052117, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42761; Mature: 42630

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKA
CCCHHHHHHHHHHHHHHHHHHHEEEHEECCCCCCCCCCCCCCCCEECCEEEECCCCHHHH
VKAVQNAVVSVINYQDNPSSSLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNS
HHHHHHHHHEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCE
AYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLAVVKISSDKIKTVAEFADSTK
EEEEECCEEECCCEEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCC
LNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEECCEEEECCCCCCCCC
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIR
CCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEE
PALGISMVNLNDLSTNALSQINIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTV
HHHCEEEEEECCCCCCCHHEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCH
NSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTTQDLTKTQ
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEECHHHHHCCC
>Mature Secondary Structure 
PSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKA
CCHHHHHHHHHHHHHHHHHHHEEEHEECCCCCCCCCCCCCCCCEECCEEEECCCCHHHH
VKAVQNAVVSVINYQDNPSSSLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNS
HHHHHHHHHEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCE
AYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLAVVKISSDKIKTVAEFADSTK
EEEEECCEEECCCEEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCC
LNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEECCEEEECCCCCCCCC
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIR
CCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEE
PALGISMVNLNDLSTNALSQINIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTV
HHHCEEEEEECCCCCCCHHEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCH
NSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTTQDLTKTQ
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEECHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471 [H]