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The map label for this gene is norA [H]

Identifier: 15675677

GI number: 15675677

Start: 1539864

End: 1541159

Strand: Reverse

Name: norA [H]

Synonym: SPy_1856

Alternate gene names: 15675677

Gene position: 1541159-1539864 (Counterclockwise)

Preceding gene: 15675682

Following gene: 15675676

Centisome position: 83.2

GC content: 38.5

Gene sequence:

>1296_bases
ATGCCCTTTGATAGTAACACTTATATTATACCATTGAAATATATTATATTCTGCTTTTTTTGTAAAATGTTTATGAAAAT
AGAGAGGAGTTCATTTTCAATGGAAGAAAAATTGTTTAACAAACATTTTGTGGCCATCACAGTAATAAACTTTATAGTCT
ATATGGTCTACTATCTTTTTACAGTTATTATTGCCTTTGTGGCGACTAGAGAGCTAGGAGCTCAGACTAGCCAGGCAGGA
TTGGCAACAGGGATTTATATTCTAGGGACTTTATTAGCCCGTTTGATTTTTGGAAAGCAGTTGGAGGTGTTTGGTCGTCG
TTTGGTTTTAAGAGGAGGTGCTATTTTTTACCTCTTAACGACCTTAGCCTACTTTTATATGCCAACGATTAGCATGATGT
ACTTGGTTCGTTTCTTGAACGGATTTGGTTATGGTGTAGTATCAACTGCGACAAATACCATTGTAACAGCCTATATTCCA
GCTCGTAAAAGAGGAGAAGGAATTAATTTTTATGGCTTGTCAACCAGTCTAGCAGCAGCTATTGGCCCTTTTGTAGGAAC
CTTTATGTTGGATAATCTTCATATTGATTTTCGCATGATTATTGTCTTATGTAGCGTCTTGATTGGGTGTGTGGTTGTTG
GTGCTTTTGCTTTTCCAGTCAAAAACATGTCTTTAAATGCGGAGCAATTGGCTAAAACCAAATCGTGGACTGTGGATAGT
TTCATTGAGAAAAAAGCCTTGTTTATCACTGCAATCGCCTTTTTAATGGGGATTGCCTATGCTTCAGTTTTAGGATTTCA
AAAATTATACACGTCTGAAATTCATTTGACAACAGTAGGCGCTTATTTCTTTGTGGTCTATGCCTTAATCATTACCATCA
CTCGTCCAGCAATGGGACGTTTAATGGATGCTAAAGGCGATAAATGGGTCTTGTACCCAAGTTATCTTTTTTTAGCAATG
GGACTCTTCTTGCTAGGTAGTGTATCGTCTGGAGGAAGCTATTTGCTTTCAGGAGCCTTGATTGGCTTTGGTTATGGCAC
TTTTATGTCTTGTGGTCAAGCCGCCTCCATACAAGGAGTGGATGAGCACCGCTTTAATACGGCTATGTCTACTTATATGA
TTGGTCTTGATTTAGGTTTAGGTGCTGGGCCTTACCTCTTGGGCTTGATTAAAGATTTGGCACTTGGTAGTGGTGTGGCT
TCCTTTAGGCACTTATTCTGGTTAGCTGCTGTGATTCCACTGATTTGTACCTTGCTTTACTTGTTAAAAACAAAGACAAG
ACAGGTTGTGTCTTAA

Upstream 100 bases:

>100_bases
TATCAATATACCGTTGCAAAATGTGATGATTCACGCTTTTCTCCAAATATTCTTTTACCAATGTATAATTTGTATCTTCA
AGAGAAATTAACATTTGCTA

Downstream 100 bases:

>100_bases
GGACAAGAAAAGGAGTTTAGTCTTATACTTAAATACAAACGTATCTTAACAGCTGTAGATAGTTCCTATGAGCCGGGATT
AGCTGTGGGTAAAGCCATTA

Product: putative antibiotic resistance protein NorA

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPFDSNTYIIPLKYIIFCFFCKMFMKIERSSFSMEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTSQAG
LATGIYILGTLLARLIFGKQLEVFGRRLVLRGGAIFYLLTTLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIP
ARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNLHIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDS
FIEKKALFITAIAFLMGIAYASVLGFQKLYTSEIHLTTVGAYFFVVYALIITITRPAMGRLMDAKGDKWVLYPSYLFLAM
GLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQAASIQGVDEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVA
SFRHLFWLAAVIPLICTLLYLLKTKTRQVVS

Sequences:

>Translated_431_residues
MPFDSNTYIIPLKYIIFCFFCKMFMKIERSSFSMEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTSQAG
LATGIYILGTLLARLIFGKQLEVFGRRLVLRGGAIFYLLTTLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIP
ARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNLHIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDS
FIEKKALFITAIAFLMGIAYASVLGFQKLYTSEIHLTTVGAYFFVVYALIITITRPAMGRLMDAKGDKWVLYPSYLFLAM
GLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQAASIQGVDEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVA
SFRHLFWLAAVIPLICTLLYLLKTKTRQVVS
>Mature_430_residues
PFDSNTYIIPLKYIIFCFFCKMFMKIERSSFSMEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTSQAGL
ATGIYILGTLLARLIFGKQLEVFGRRLVLRGGAIFYLLTTLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIPA
RKRGEGINFYGLSTSLAAAIGPFVGTFMLDNLHIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDSF
IEKKALFITAIAFLMGIAYASVLGFQKLYTSEIHLTTVGAYFFVVYALIITITRPAMGRLMDAKGDKWVLYPSYLFLAMG
LFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQAASIQGVDEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVAS
FRHLFWLAAVIPLICTLLYLLKTKTRQVVS

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47536; Mature: 47405

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFDSNTYIIPLKYIIFCFFCKMFMKIERSSFSMEEKLFNKHFVAITVINFIVYMVYYLF
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVIIAFVATRELGAQTSQAGLATGIYILGTLLARLIFGKQLEVFGRRLVLRGGAIFYLLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
TLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCEEEECHHHHHHH
IGPFVGTFMLDNLHIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHH
FIEKKALFITAIAFLMGIAYASVLGFQKLYTSEIHLTTVGAYFFVVYALIITITRPAMGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LMDAKGDKWVLYPSYLFLAMGLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQAASIQGV
HHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCC
DEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVASFRHLFWLAAVIPLICTLLY
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LLKTKTRQVVS
HHHHHHHHHCC
>Mature Secondary Structure 
PFDSNTYIIPLKYIIFCFFCKMFMKIERSSFSMEEKLFNKHFVAITVINFIVYMVYYLF
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVIIAFVATRELGAQTSQAGLATGIYILGTLLARLIFGKQLEVFGRRLVLRGGAIFYLLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
TLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCEEEECHHHHHHH
IGPFVGTFMLDNLHIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHH
FIEKKALFITAIAFLMGIAYASVLGFQKLYTSEIHLTTVGAYFFVVYALIITITRPAMGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LMDAKGDKWVLYPSYLFLAMGLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQAASIQGV
HHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCC
DEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVASFRHLFWLAAVIPLICTLLY
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LLKTKTRQVVS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]