Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is glpF.2 [H]

Identifier: 15675676

GI number: 15675676

Start: 1538514

End: 1539461

Strand: Reverse

Name: glpF.2 [H]

Synonym: SPy_1854

Alternate gene names: 15675676

Gene position: 1539461-1538514 (Counterclockwise)

Preceding gene: 15675677

Following gene: 15675674

Centisome position: 83.1

GC content: 38.08

Gene sequence:

>948_bases
ATGATCATTTTATTTATTATTTTATTACCTTTACATTCATCAATAAGCCTGTTAAAATGGTATTTGTTATATTTTATTAT
TTGGAGGAAACCAGAAAACATGGAAATGACATGGACTGTGAAATACATCACAGAATTTATCGCAACGGCTTTTTTGATTA
TTTTGGGAAATGGAGCTGTTGCTAACGTCGACTTAAAAGGAACAAAAGGACATAACTCAGGTTGGTTAGTGATTGCTTTT
GGCTATGGCTTAGGAGTTATGATGCCAGCTTTGATGTTTGGTAATGTATCTGGAAACCATATTAATCCTGCTTTCACAGT
TGGACTAGCAGTATCAGGCTTGTTCCCATGGGCTCACGTCTTACAATACGTTGTGGCACAATTACTTGGAGCTATCTTTG
GTCAGTTGGTAGTGGTAATGGTTTATAAACCTTACTTTATGAAAACTGAAAATCCAAATCATGTTTTAGGCTCATTCTCA
ACGATTTCATCTCTTGATAATGGTCAAAAAGACAGTCATAAAGCCTCTTATATCAATGGTTTCTTAAACGAATTTGTAGG
TTCATTTGTTCTTTTCTTTGGTGCTTTGGCTTTGACTAAAAACTACTTTGGGGTAGAGTTAGTTGGTAAATTGATTGAAG
CAGGCTACGACCAAACAACTGCAGCAACACAAATTTCACCATACGTGACAGGCTCATTGGCGGTTGCTCACATTGGTATT
GGTTTCTTAGTTATGGTCTTGGTTACTTCATTAGGTGGACCAACTGGGCCAGCACTAAACCCAGCGCGTGATTTTGGGCC
TCGTTTGTTACACCACTTCTTACCAAAATCAGTTCTTGGTCAAGCCAAAGGTGATTCAAAATGGTGGTATGCATGGGTTC
CTGTAGTTGCACCTATCTTAGCGGCGATAGTAGCCGTAGCAGCGTTTAAATACCTTTATATCAGATAA

Upstream 100 bases:

>100_bases
AATAAAAAATGTTATAATACTATGAAATAAAGTGATAAAGATAAGGCCTTTTATGGTCCTTTTCTTTACCGCTTTTATTA
TTGTGTGAAAATAACACTTA

Downstream 100 bases:

>100_bases
AAAAAGAACTAAAGCTTCTTTTAGACTCAAGACAAGCTCGCTTAAGGAACTTGTCTTTTTTATATGAGTTAAGCGAAATC
TAATACAAACTTGACTGTCT

Product: putative glycerol uptake facilitator protein

Products: glycerol [Cytoplasm] [C]

Alternate protein names: Aquaglyceroporin; Glyceroaquaporin [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLVIAF
GYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFS
TISSLDNGQKDSHKASYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAFKYLYIR

Sequences:

>Translated_315_residues
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLVIAF
GYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFS
TISSLDNGQKDSHKASYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAFKYLYIR
>Mature_315_residues
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLVIAF
GYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFS
TISSLDNGQKDSHKASYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAFKYLYIR

Specific function: Mixed channel protein that transports both water and glycerol [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4826645, Length=298, Percent_Identity=30.2013422818792, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI22538420, Length=279, Percent_Identity=30.4659498207885, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI157266307, Length=280, Percent_Identity=27.8571428571429, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4502187, Length=280, Percent_Identity=28.2142857142857, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790362, Length=288, Percent_Identity=30.5555555555556, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=284, Percent_Identity=27.112676056338, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994009, Length=271, Percent_Identity=26.5682656826568, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=277, Percent_Identity=27.0758122743682, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544068, Length=271, Percent_Identity=24.7232472324723, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=279, Percent_Identity=26.8817204301075, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=279, Percent_Identity=26.8817204301075, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321054, Length=229, Percent_Identity=31.8777292576419, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45550503, Length=275, Percent_Identity=26.5454545454545, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 34394; Mature: 34394

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAV
CHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCE
ANVDLKGTKGHNSGWLVIAFGYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHV
EEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHH
LQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFSTISSLDNGQKDSHKASYING
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHCCHHHHHHHCCCCCCHHHHHHHHH
FLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHH
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPIL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEHHHHHHHHH
AAIVAVAAFKYLYIR
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAV
CHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCE
ANVDLKGTKGHNSGWLVIAFGYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHV
EEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHH
LQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFSTISSLDNGQKDSHKASYING
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHCCHHHHHHHCCCCCCHHHHHHHHH
FLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHH
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPIL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEHHHHHHHHH
AAIVAVAAFKYLYIR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]