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The map label for this gene is mvaK2

Identifier: 15674903

GI number: 15674903

Start: 725374

End: 726381

Strand: Direct

Name: mvaK2

Synonym: SPy_0878

Alternate gene names: NA

Gene position: 725374-726381 (Clockwise)

Preceding gene: 15674902

Following gene: 15674904

Centisome position: 39.16

GC content: 42.56

Gene sequence:

>1008_bases
ATGTCTAATTATTGTGTGCAAACAGGTGGGAAACTATACCTCACAGGCGAATATGCTATCTTAACACCAGGACAAAAAGC
CTTAATTCACTTTATTCCATTGATGATGACAGCAGAAATTAGCCCAGCAGCCCATATTCAATTAGCTTCAGATATGTTTT
CCCATAAAGCGGGCATGACACCCGATGCCTCTTATGCACTGATTCAAGCAACGGTTAAAACCTTTGCTGATTATCTAGGA
CAGTCAATTGACCAACTGGAGCCATTTTCCCTAATTATAACGGGAAAAATGGAGCGCGATGGCAAAAAATTTGGCATTGG
TTCAAGTGGTAGCGTCACCCTCTTAACCTTAAAGGCCTTATCGGCCTATTATCAGATTACTTTAACCCCAGAGTTACTCT
TTAAACTAGCGGCTTATACCTTGCTTAAGCAAGGAGATAATGGGTCTATGGGGGATATTGCCTGTATCGCTTATCAGACT
TTAGTCGCCTATACCTCCTTTGACCGAGAACAGGTCAGTAATTGGCTGCAGACCATGCCCTTAAAAAAACTTCTCGTCAA
AGATTGGGGTTACCATATCCAAGTCATTCAACCAGCCCTGCCTTGTGACTTTTTGGTTGGCTGGACTAAAATACCTGCTA
TTTCAAGGCAGATGATTCAACAAGTGACAGCGAGCATTACCCCAGCTTTCTTAAGAACAAGTTACCAGCTAACGCAATCA
GCTATGGTAGCTTTGCAAGAAGGTCATAAGGAAGAACTCAAGAAAAGTTTAGCAGGAGCAAGTCATCTCCTAAAAGAGCT
TCATCCAGCTATCTACCATCCTAAGCTAGTAACCTTGGTAGCTGCTTGTCAGAAGCAAGATGCTGTTGCTAAATCTTCAG
GTTCTGGTGGTGGAGATTGTGGCATCGCGCTTGCCTTTAATCAGGATGCTAGAGATACCCTTATTTCCAAATGGCAAGAA
GCTGATATCGCATTACTTTATCAAGAAAGGTGGGGAGAGAATGACTAA

Upstream 100 bases:

>100_bases
AATGTGAAGGTCCTATGTTTAGAAAAAGACTTGGCTCAACTAGCAGAACGACTTGGCAAGAACTACCGTATTATCGTTTC
AAAAACAAAGGATTTACCAG

Downstream 100 bases:

>100_bases
CCGTAAAGATGATCACATCAAATATGCTCTCAAGTACCAATCGCCTTATAATGCTTTTGATGACATAGAACTCATACACC
ATTCCTTACCTAGCTATGAT

Product: phosphomevalonate kinase

Products: ADP; (R)-5-diphosphomevalonate

Alternate protein names: Mevalonate Kinase; Isopentenyl-Diphosphate Delta-Isomerase; GHMP Kinase

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFSHKAGMTPDASYALIQATVKTFADYLG
QSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQT
LVAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTASITPAFLRTSYQLTQS
AMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDCGIALAFNQDARDTLISKWQE
ADIALLYQERWGEND

Sequences:

>Translated_335_residues
MSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFSHKAGMTPDASYALIQATVKTFADYLG
QSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQT
LVAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTASITPAFLRTSYQLTQS
AMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDCGIALAFNQDARDTLISKWQE
ADIALLYQERWGEND
>Mature_334_residues
SNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFSHKAGMTPDASYALIQATVKTFADYLGQ
SIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQTL
VAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTASITPAFLRTSYQLTQSA
MVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDCGIALAFNQDARDTLISKWQEA
DIALLYQERWGEND

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.4.2

Molecular weight: Translated: 36690; Mature: 36559

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFSHKAGMT
CCCCEEECCCEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
PDASYALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKAL
CCCHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCCCCEECCCCCCCEEEEEHHHH
SAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQTLVAYTSFDREQVSNWLQTMP
HHHEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
LKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTASITPAFLRTSYQLTQS
HHHHHHHHCCCEEEEECCCCCHHHHHCCHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDC
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCE
GIALAFNQDARDTLISKWQEADIALLYQERWGEND
EEEEEECCCHHHHHHHHHHCCCEEEEEHHHCCCCC
>Mature Secondary Structure 
SNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFSHKAGMT
CCCEEECCCEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
PDASYALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKAL
CCCHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCCCCEECCCCCCCEEEEEHHHH
SAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQTLVAYTSFDREQVSNWLQTMP
HHHEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
LKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTASITPAFLRTSYQLTQS
HHHHHHHHCCCEEEEECCCCCHHHHHCCHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDC
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCE
GIALAFNQDARDTLISKWQEADIALLYQERWGEND
EEEEEECCCHHHHHHHHHHCCCEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-phosphomevalonate

Specific reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA