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The map label for this gene is mvaD

Identifier: 15674902

GI number: 15674902

Start: 724437

End: 725381

Strand: Direct

Name: mvaD

Synonym: SPy_0877

Alternate gene names: NA

Gene position: 724437-725381 (Clockwise)

Preceding gene: 15674901

Following gene: 15674903

Centisome position: 39.11

GC content: 40.53

Gene sequence:

>945_bases
GTGGATCCAAATGTTATAACCGTAACATCCTATGCTAACATTGCTATTATCAAATATTGGGGAAAAGAGAATCAAGCTAA
GATGATTCCTTCGACCTCTAGCATTTCTTTGACTTTGGAAAACATGTTCACCACAACCAGCGTTTCCTTCTTACCAGATA
CTGCAACCAGTGATCAGTTTTACATTAACGGTATCTTGCAAAATGACGAAGAACATACCAAAATTTCTGCTATCATTGAC
CAATTTCGCCAACCTGGTCAGGCTTTTGTAAAGATGGAAACTCAAAATAATATGCCAACAGCTGCAGGTTTATCATCAAG
TTCCAGTGGCTTATCAGCCTTGGTTAAAGCCTGTGACCAATTATTTGACACCCAGCTAGATCAGAAAGCTTTAGCTCAAA
AGGCTAAGTTCGCCTCAGGATCATCTTCTCGTTCTTTTTTTGGCCCAGTCGCTGCTTGGGACAAAGATAGTGGTGCTATT
TACAAGGTTGAGACTGACTTGAAAATGGCCATGATTATGCTGGTCTTAAATGCTGCGAAAAAGCCAATTTCTAGCCGAGA
GGGCATGAAGTTATGCCGCGATACCTCAACTACATTTGATCAATGGGTAGAACAATCGGCAATCGATTACCAACATATGC
TTACCTATCTCAAAACTAATAATTTTGAGAAAGTTGGTCAGTTAACAGAAGCTAATGCCTTGGCCATGCATGCCACGACA
AAGACAGCCAATCCTCCTTTTTCTTACCTAACAAAAGAGTCTTACCAGGCTATGGAGGCTGTGAAAGAACTGCGTCAAGA
AGGTTTTGCTTGTTATTTTACCATGGACGCAGGTCCAAATGTGAAGGTCCTATGTTTAGAAAAAGACTTGGCTCAACTAG
CAGAACGACTTGGCAAGAACTACCGTATTATCGTTTCAAAAACAAAGGATTTACCAGATGTCTAA

Upstream 100 bases:

>100_bases
CAGGCGGTGGCTTGGGTGGCTGTATGATTGCCCTAGCAGATACCAAAGACATGGCCGAAAAAATCAGTCACAGATTAAAA
GAAGAAGGAGCCGTAAACAC

Downstream 100 bases:

>100_bases
TTATTGTGTGCAAACAGGTGGGAAACTATACCTCACAGGCGAATATGCTATCTTAACACCAGGACAAAAAGCCTTAATTC
ACTTTATTCCATTGATGATG

Product: mevalonate pyrophosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGILQNDEEHTKISAIID
QFRQPGQAFVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAI
YKVETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDQWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATT
KTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV

Sequences:

>Translated_314_residues
MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGILQNDEEHTKISAIID
QFRQPGQAFVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAI
YKVETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDQWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATT
KTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV
>Mature_314_residues
MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGILQNDEEHTKISAIID
QFRQPGQAFVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAI
YKVETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDQWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATT
KTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=318, Percent_Identity=27.6729559748428, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17537201, Length=318, Percent_Identity=27.3584905660377, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17537203, Length=179, Percent_Identity=27.9329608938547, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324371, Length=316, Percent_Identity=30.0632911392405, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28571205, Length=320, Percent_Identity=26.5625, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 34756; Mature: 34756

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTTTSVSFLPDTATSDQF
CCCCEEEEECCCCEEEEEEECCCCCCEECCCCCCEEEEEHHHHEEEEEEECCCCCCCCCE
YINGILQNDEEHTKISAIIDQFRQPGQAFVKMETQNNMPTAAGLSSSSSGLSALVKACDQ
EEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
LFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAK
HHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHC
KPISSREGMKLCRDTSTTFDQWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATT
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEC
KTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMDAGPNVKVLCLEKDLAQLAERLGKN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECHHHHHHHHHHCCC
YRIIVSKTKDLPDV
EEEEEECCCCCCCC
>Mature Secondary Structure
MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTTTSVSFLPDTATSDQF
CCCCEEEEECCCCEEEEEEECCCCCCEECCCCCCEEEEEHHHHEEEEEEECCCCCCCCCE
YINGILQNDEEHTKISAIIDQFRQPGQAFVKMETQNNMPTAAGLSSSSSGLSALVKACDQ
EEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
LFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAK
HHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHC
KPISSREGMKLCRDTSTTFDQWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATT
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEC
KTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMDAGPNVKVLCLEKDLAQLAERLGKN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECHHHHHHHHHHCCC
YRIIVSKTKDLPDV
EEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA