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The map label for this gene is mvaK1 [H]

Identifier: 15674901

GI number: 15674901

Start: 723562

End: 724455

Strand: Direct

Name: mvaK1 [H]

Synonym: SPy_0876

Alternate gene names: 15674901

Gene position: 723562-724455 (Clockwise)

Preceding gene: 15674900

Following gene: 15674902

Centisome position: 39.06

GC content: 42.28

Gene sequence:

>894_bases
ATGAAAAGACAAAAAATGAACGAAAACATTGGATATGGTAAGGCACACAGTAAGATCATTTTGATAGGTGAGCATGCTGT
TGTGTATGGCTACCCAGCTATTGCTTTGCCTTTAACAGATATTGAGGTGGTTTGTCATATTTTTCCAGCTGATAAGCCAT
TGGTCTTTGATTTTTATGATACTCTATCAACAGCCATTTATGCTTCCTTGGATTATTTGCAGCGACTACAAGAACCAATT
GCTTATGAGATTGTTTCACAAGTGCCACAAAAGCGTGGTATGGGGTCTTCGGCAGCCGTTTCTATTGCAGCTATTAGAGC
CGTTTTTTCTTATTGTCAAGAACCCCTCTCGGATGATTTGTTGGAAATTTTAGTCAACAAGGCAGAAATTATTGCCCACA
CCAATCCTAGTGGTTTAGATGCCAAGACATGCCTTAGTGACCATGCCATTAAGTTTATCCGAAACATTGGCTTTGAAACT
ATCGAAATCGCCTTAAATGGTTATCTTATCATTGCAGATACAGGGATTCACGGTCATACACGTGAGGCCGTCAATAAGGT
AGCACAGTTTGAGGAAACGAATTTGCCCTATCTGGCTAAACTAGGAGCTTTGACACAAGCCCTTGAAAGAGCGATTAACC
AAAAAAATAAGGTGGCTATCGGTCAGCTCATGACACAAGCGCACTCTGCTTTAAAGGCCATTGGCGTTAGCATCAGTAAA
GCTGACCAACTTGTGGAGGCTGCCCTAAGAGCAGGTGCTTTAGGCGCTAAGATGACAGGCGGTGGCTTGGGTGGCTGTAT
GATTGCCCTAGCAGATACCAAAGACATGGCCGAAAAAATCAGTCACAGATTAAAAGAAGAAGGAGCCGTAAACACGTGGA
TCCAAATGTTATAA

Upstream 100 bases:

>100_bases
TTGTTAATTTCAGTGAAGAAATGATTTTAAAAAGATATATCATCGCATTTTCTAATCATTTAGTGTAAAATAGTAAGGTA
AAAGTTTAGAAGAATTAGTA

Downstream 100 bases:

>100_bases
CCGTAACATCCTATGCTAACATTGCTATTATCAAATATTGGGGAAAAGAGAATCAAGCTAAGATGATTCCTTCGACCTCT
AGCATTTCTTTGACTTTGGA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKRQKMNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTAIYASLDYLQRLQEPI
AYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFET
IEIALNGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISK
ADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML

Sequences:

>Translated_297_residues
MKRQKMNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTAIYASLDYLQRLQEPI
AYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFET
IEIALNGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISK
ADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML
>Mature_297_residues
MKRQKMNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTAIYASLDYLQRLQEPI
AYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFET
IEIALNGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISK
ADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI78707210, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32144; Mature: 32144

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQKMNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYD
CCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCEECHHHHHHHEEECCCCCCEEEHHHH
TLSTAIYASLDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
LEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIALNGYLIIADTGIHGHT
HHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHH
REAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
ADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MKRQKMNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYD
CCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCEECHHHHHHHEEECCCCCCEEEHHHH
TLSTAIYASLDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
LEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIALNGYLIIADTGIHGHT
HHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHH
REAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
ADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]