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The map label for this gene is atoB [H]

Identifier: 15674351

GI number: 15674351

Start: 128936

End: 130120

Strand: Direct

Name: atoB [H]

Synonym: SPy_0140

Alternate gene names: 15674351

Gene position: 128936-130120 (Clockwise)

Preceding gene: 15674350

Following gene: 15674352

Centisome position: 6.96

GC content: 42.45

Gene sequence:

>1185_bases
ATGACTAAAGAAGTGGTGATCACATCTGCTTATCGTACCCCGATAGGAAATTTTGGAGGAGTCTTTAAATCTTTATCAGC
CGTAGATTTGGGGGTGACAGTTGTTACAAAAATTTTAGCTGATACCGGTCTTAAAAGTGATGCCATTGATGAAGTGATCT
TTGGGAATGTGTTACATGCAGGTCTGGGTCAAAATGTTGCCCGGCAAGTAGCGCTAAATGCGGGGCTTTCTTATGATACC
CCTGCTTTTACGATTGATATGGTCTGTGGTTCTGGCTTAAAAGCAGTTGAGTTAGGTGCTCAAAAGATTCAAACGGGCAA
CGCTGATATTGTTTTAGTTGGTGGTACCGAAAACATGAGTCAAGCACCTTACGTTTTACAAGGCCAACGTTGGGGATCTC
GTATGGGAGATAGTAAAGTAGTAGATACCATGCTTAAAGATGGGTTGAGTGATGCTTTTGCAGGTTATCACATGGGTATA
ACAGCCGAAAATATTGTGCAACAGTATGGACTGACCAGAGAAGAACAAGATGCCTTTGCAGCTGATAGCCAACGTAAAGC
CCAACTTGCCATAGAAAAAGGTCGTTTCAAAGAAGAGATTGCACCTGTCACTATTCCTCAGCGTAAAGGTGAACCTTTAC
TCGTTGATCAAGATGAATACCCTAAATTTGGAACGACAGTGGATAAGTTAGCAAAGTTACGCCCTGCTTTTATCAAAGAT
GAGGGGACAGTAACTGCTGGTAATGCTTCAGGAATCAATGATGGAGCAGCGGCAATTTTATTGATGAGTAAAGAAAAAGC
TGAAGAATTAGGGCTCCCTATTTTAGCTAAAATCACTAGTTATGCAAGTGCAGGTGTAGACCCAAGTATTATGGGCTGCG
GACCAATACCTGCTACGAAAAAGGCTCTTGCAAAGGCTCAGCTGACAATTGATGACATTGATTTGATTGAAGCAAACGAA
GCTTTTGCTGCTCAGGCTTTAGCGGTTTCACGAGACCTTGGTTTTGACAATGAAAAAGTTAATGTCAATGGAGGAGCTAT
TGCTTTGGGTCACCCGATTGGAGCATCAGGTGCTCGTATTTTAGTCACCTTATTAGCAGAAATGGCTAAGCGTGATGTGA
GACATGGCTTAGCAACGCTTTGTATTGGTGGTGGCCAAGGTCAAAGTATCATCGTAACAAGATAG

Upstream 100 bases:

>100_bases
TTTAGTTATAGCATATATAAAAAAACGATATTTGTTTATTATAGTTCACATTATATAATAAAAATGTAAGCGTTTCAATA
ATGAAAAAGGAGAAGTTTCT

Downstream 100 bases:

>100_bases
AAGGTAACCGTATGAAAGAGAATAAAAGAATAGCAATAGCAGAAGCTATCAGTCATATTAAAGATGGTGACACGATTATG
GTCGGTGGTTTTATGGCTAA

Product: putative acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTKEVVITSAYRTPIGNFGGVFKSLSAVDLGVTVVTKILADTGLKSDAIDEVIFGNVLHAGLGQNVARQVALNAGLSYDT
PAFTIDMVCGSGLKAVELGAQKIQTGNADIVLVGGTENMSQAPYVLQGQRWGSRMGDSKVVDTMLKDGLSDAFAGYHMGI
TAENIVQQYGLTREEQDAFAADSQRKAQLAIEKGRFKEEIAPVTIPQRKGEPLLVDQDEYPKFGTTVDKLAKLRPAFIKD
EGTVTAGNASGINDGAAAILLMSKEKAEELGLPILAKITSYASAGVDPSIMGCGPIPATKKALAKAQLTIDDIDLIEANE
AFAAQALAVSRDLGFDNEKVNVNGGAIALGHPIGASGARILVTLLAEMAKRDVRHGLATLCIGGGQGQSIIVTR

Sequences:

>Translated_394_residues
MTKEVVITSAYRTPIGNFGGVFKSLSAVDLGVTVVTKILADTGLKSDAIDEVIFGNVLHAGLGQNVARQVALNAGLSYDT
PAFTIDMVCGSGLKAVELGAQKIQTGNADIVLVGGTENMSQAPYVLQGQRWGSRMGDSKVVDTMLKDGLSDAFAGYHMGI
TAENIVQQYGLTREEQDAFAADSQRKAQLAIEKGRFKEEIAPVTIPQRKGEPLLVDQDEYPKFGTTVDKLAKLRPAFIKD
EGTVTAGNASGINDGAAAILLMSKEKAEELGLPILAKITSYASAGVDPSIMGCGPIPATKKALAKAQLTIDDIDLIEANE
AFAAQALAVSRDLGFDNEKVNVNGGAIALGHPIGASGARILVTLLAEMAKRDVRHGLATLCIGGGQGQSIIVTR
>Mature_393_residues
TKEVVITSAYRTPIGNFGGVFKSLSAVDLGVTVVTKILADTGLKSDAIDEVIFGNVLHAGLGQNVARQVALNAGLSYDTP
AFTIDMVCGSGLKAVELGAQKIQTGNADIVLVGGTENMSQAPYVLQGQRWGSRMGDSKVVDTMLKDGLSDAFAGYHMGIT
AENIVQQYGLTREEQDAFAADSQRKAQLAIEKGRFKEEIAPVTIPQRKGEPLLVDQDEYPKFGTTVDKLAKLRPAFIKDE
GTVTAGNASGINDGAAAILLMSKEKAEELGLPILAKITSYASAGVDPSIMGCGPIPATKKALAKAQLTIDDIDLIEANEA
FAAQALAVSRDLGFDNEKVNVNGGAIALGHPIGASGARILVTLLAEMAKRDVRHGLATLCIGGGQGQSIIVTR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=49.616368286445, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=42.4936386768448, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=41.2213740458015, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=42.8934010152284, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=33.2547169811321, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.690537084399, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=55.6122448979592, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=59.5419847328244, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44.75, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=42, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=34.3065693430657, Blast_Score=215, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=47.3282442748092, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=40.8629441624365, Blast_Score=277, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=38.7755102040816, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=31.042654028436, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=30.4239401496259, Blast_Score=164, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=44.9748743718593, Blast_Score=312, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=38.5390428211587, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=51.9181585677749, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=42.4936386768448, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=41.1764705882353, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=32.093023255814, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41254; Mature: 41123

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEVVITSAYRTPIGNFGGVFKSLSAVDLGVTVVTKILADTGLKSDAIDEVIFGNVLHA
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLGQNVARQVALNAGLSYDTPAFTIDMVCGSGLKAVELGAQKIQTGNADIVLVGGTENMS
HCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHCHHHHCCCCCCEEEECCCCCCC
QAPYVLQGQRWGSRMGDSKVVDTMLKDGLSDAFAGYHMGITAENIVQQYGLTREEQDAFA
CCCEEEECCHHCCCCCCHHHHHHHHHHCHHHHHCCEECCCCHHHHHHHHCCCCCHHHHHH
ADSQRKAQLAIEKGRFKEEIAPVTIPQRKGEPLLVDQDEYPKFGTTVDKLAKLRPAFIKD
CCCCHHHHHHHHHCCCHHHCCCEECCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCEECC
EGTVTAGNASGINDGAAAILLMSKEKAEELGLPILAKITSYASAGVDPSIMGCGPIPATK
CCCEEECCCCCCCCCCEEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCHHH
KALAKAQLTIDDIDLIEANEAFAAQALAVSRDLGFDNEKVNVNGGAIALGHPIGASGARI
HHHHHHEEEECCCCEEECCHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCCHHHH
LVTLLAEMAKRDVRHGLATLCIGGGQGQSIIVTR
HHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure 
TKEVVITSAYRTPIGNFGGVFKSLSAVDLGVTVVTKILADTGLKSDAIDEVIFGNVLHA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLGQNVARQVALNAGLSYDTPAFTIDMVCGSGLKAVELGAQKIQTGNADIVLVGGTENMS
HCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHCHHHHCCCCCCEEEECCCCCCC
QAPYVLQGQRWGSRMGDSKVVDTMLKDGLSDAFAGYHMGITAENIVQQYGLTREEQDAFA
CCCEEEECCHHCCCCCCHHHHHHHHHHCHHHHHCCEECCCCHHHHHHHHCCCCCHHHHHH
ADSQRKAQLAIEKGRFKEEIAPVTIPQRKGEPLLVDQDEYPKFGTTVDKLAKLRPAFIKD
CCCCHHHHHHHHHCCCHHHCCCEECCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCEECC
EGTVTAGNASGINDGAAAILLMSKEKAEELGLPILAKITSYASAGVDPSIMGCGPIPATK
CCCEEECCCCCCCCCCEEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCHHH
KALAKAQLTIDDIDLIEANEAFAAQALAVSRDLGFDNEKVNVNGGAIALGHPIGASGARI
HHHHHHEEEECCCCEEECCHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCCHHHH
LVTLLAEMAKRDVRHGLATLCIGGGQGQSIIVTR
HHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]