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The map label for this gene is aroE

Identifier: 15673739

GI number: 15673739

Start: 1814827

End: 1815687

Strand: Reverse

Name: aroE

Synonym: L0061

Alternate gene names: 15673739

Gene position: 1815687-1814827 (Counterclockwise)

Preceding gene: 15673740

Following gene: 15673738

Centisome position: 76.75

GC content: 36.93

Gene sequence:

>861_bases
ATGAACATTAACGGCTACACTCGTATGGCTGCTGTTGTAGCAAACCCAATTAAACACAGCTTGTCACCATTTATTCATAA
TCTGGCTTTTGATTTAACGAATGAAAATGGTGTTTATTTAGCATGGGAAGTTGAGGCTGAAAAATTGCCAGCTATTGTGG
ATAATGTTCGTACTTTGGACATGTATGGACTTAATATTTCAATGCCTTATAAAACAGAAATTACTCCATTTATGGATGAA
TTGAGTCCGGCAGCTGAATTAATTGGAGCTGTTAATACAGTAGTCAATCAATCAGGGAAATTAATTGGACACAATACAGA
TGGCATAGGATTTTTCAATAGTTTAGAAAAATATCATTTCAATATCCAAAATAAACAAATGCTTATTCTTGGTGGAGGGG
GTGCAGCAATTGCAATTATTGCTCAGGCAGCTTTGTCTGGAGCTAAAAAAATTGTGGTCGCAGCAAGAAAATCGGCCTCA
TATATTCCGCTAAAAGAAAAATTGGAAAAGCTGTCAGTAAAAACAGGGATTGAAATTTTACTGACAGACTTATCTGAAGC
TGATAGATTACAAAAAGAGTTGAAACAGACCGACTTATTAGTAAATGCAACCTCAGTCGGAATGGACGGAGAATCTTTGC
CGCTGGAAAAGAGCTTAGTTCTTCCTGAAAAACTTTTGGTGGTAGATGCTATTTATAAAGTTAGAGAAACACCATTTTTA
CGTTGGGCAAAAGGGCAAGGAGCTCAAACTGAAAATGGACTTGGCATGCTCATTGGACAGGCGGCGGAAAGCTTTTATTT
ATGGACAGGTAAAAAAATGCCTGTTGCAGAAATTACATTAGAAATGGAGAAAGAAGCATGA

Upstream 100 bases:

>100_bases
ATAGAATTTACTGACAAAGACACTAGCATAGTTGAGCCTTTTGCGTCTTGCGCAATTATGGATATATTAGTAGTTTCATC
AGTAATTTTGGAGGATTTTT

Downstream 100 bases:

>100_bases
AATTAAATGTGAATTTACCAGAACATCCCTATGATGTCATCATCGAAAATGGGGCCTTGGCTAATATTGGAACTTGGGTT
TCTTCATTGTGGAAGAAGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNINGYTRMAAVVANPIKHSLSPFIHNLAFDLTNENGVYLAWEVEAEKLPAIVDNVRTLDMYGLNISMPYKTEITPFMDE
LSPAAELIGAVNTVVNQSGKLIGHNTDGIGFFNSLEKYHFNIQNKQMLILGGGGAAIAIIAQAALSGAKKIVVAARKSAS
YIPLKEKLEKLSVKTGIEILLTDLSEADRLQKELKQTDLLVNATSVGMDGESLPLEKSLVLPEKLLVVDAIYKVRETPFL
RWAKGQGAQTENGLGMLIGQAAESFYLWTGKKMPVAEITLEMEKEA

Sequences:

>Translated_286_residues
MNINGYTRMAAVVANPIKHSLSPFIHNLAFDLTNENGVYLAWEVEAEKLPAIVDNVRTLDMYGLNISMPYKTEITPFMDE
LSPAAELIGAVNTVVNQSGKLIGHNTDGIGFFNSLEKYHFNIQNKQMLILGGGGAAIAIIAQAALSGAKKIVVAARKSAS
YIPLKEKLEKLSVKTGIEILLTDLSEADRLQKELKQTDLLVNATSVGMDGESLPLEKSLVLPEKLLVVDAIYKVRETPFL
RWAKGQGAQTENGLGMLIGQAAESFYLWTGKKMPVAEITLEMEKEA
>Mature_286_residues
MNINGYTRMAAVVANPIKHSLSPFIHNLAFDLTNENGVYLAWEVEAEKLPAIVDNVRTLDMYGLNISMPYKTEITPFMDE
LSPAAELIGAVNTVVNQSGKLIGHNTDGIGFFNSLEKYHFNIQNKQMLILGGGGAAIAIIAQAALSGAKKIVVAARKSAS
YIPLKEKLEKLSVKTGIEILLTDLSEADRLQKELKQTDLLVNATSVGMDGESLPLEKSLVLPEKLLVVDAIYKVRETPFL
RWAKGQGAQTENGLGMLIGQAAESFYLWTGKKMPVAEITLEMEKEA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=37.0503597122302, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1789675, Length=284, Percent_Identity=33.8028169014084, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320332, Length=301, Percent_Identity=29.2358803986711, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_LACLA (Q9CES7)

Other databases:

- EMBL:   AE005176
- PIR:   E86844
- RefSeq:   NP_267913.1
- ProteinModelPortal:   Q9CES7
- SMR:   Q9CES7
- GeneID:   1115420
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0061
- NMPDR:   fig|272623.1.peg.1801
- HOGENOM:   HBG553408
- OMA:   NARYLAF
- ProtClustDB:   PRK00258
- BioCyc:   LLAC272623:L0061-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31205; Mature: 31205

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINGYTRMAAVVANPIKHSLSPFIHNLAFDLTNENGVYLAWEVEAEKLPAIVDNVRTLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEECHHHCHHHHHCCEEEE
MYGLNISMPYKTEITPFMDELSPAAELIGAVNTVVNQSGKLIGHNTDGIGFFNSLEKYHF
EECCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHEE
NIQNKQMLILGGGGAAIAIIAQAALSGAKKIVVAARKSASYIPLKEKLEKLSVKTGIEIL
EECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEE
LTDLSEADRLQKELKQTDLLVNATSVGMDGESLPLEKSLVLPEKLLVVDAIYKVRETPFL
EECHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
RWAKGQGAQTENGLGMLIGQAAESFYLWTGKKMPVAEITLEMEKEA
EEECCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHEEEEEECCC
>Mature Secondary Structure
MNINGYTRMAAVVANPIKHSLSPFIHNLAFDLTNENGVYLAWEVEAEKLPAIVDNVRTLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEECHHHCHHHHHCCEEEE
MYGLNISMPYKTEITPFMDELSPAAELIGAVNTVVNQSGKLIGHNTDGIGFFNSLEKYHF
EECCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHEE
NIQNKQMLILGGGGAAIAIIAQAALSGAKKIVVAARKSASYIPLKEKLEKLSVKTGIEIL
EECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEE
LTDLSEADRLQKELKQTDLLVNATSVGMDGESLPLEKSLVLPEKLLVVDAIYKVRETPFL
EECHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
RWAKGQGAQTENGLGMLIGQAAESFYLWTGKKMPVAEITLEMEKEA
EEECCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471