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The map label for this gene is aroB

Identifier: 15673738

GI number: 15673738

Start: 1813760

End: 1814830

Strand: Reverse

Name: aroB

Synonym: L0060

Alternate gene names: 15673738

Gene position: 1814830-1813760 (Counterclockwise)

Preceding gene: 15673739

Following gene: 15673737

Centisome position: 76.72

GC content: 38.28

Gene sequence:

>1071_bases
ATGAAATTAAATGTGAATTTACCAGAACATCCCTATGATGTCATCATCGAAAATGGGGCCTTGGCTAATATTGGAACTTG
GGTTTCTTCATTGTGGAAGAAGCAAAAAATTGTTTTGATTTCTGATAATCATGTCAATGGACTTTATGGTCAAAAAGTTG
TTGACCAACTTGAAAAAGTAGGTTTTGAAGTGGCAACTTTTGAATTTCCAGAAGGAGAAGCCAGTAAAAATTTACTGACA
GCCGAAAATGCTTGGAACTTTTGTGCCGAATTTGGATTGACTCGTTCTGACGGAATTATTGCACTCGGTGGTGGAGTAAC
AGGTGATTTAGCTGGTTTTGTAGCTTCTACTTACATGCGTGGCATCCATTTCTTACAAATTCCAACAAGTTTGACCGCCC
AAGTGGATAGTTCTATTGGTGGGAAAACAGGAATTAATTCCAAAATGGCTAAAAATATGATTGGGACTTTTACACAGCCT
GACGGCGTGTTAATTGACCCAGAAGTTCTGCAAACGCTCGGTCAAAGAGAATTCCGTGAAGGACTGGGGGAGGTCATCAA
GTGCGCCCTAATTGCTGACAAAGATCTCTGGAATTTACTGACAGACTTGTCGGCGGATGATTTAGTAAAAAAGCTTGATA
AGATTGAAGAAATTATCTATCGGTCTTGTGAAGTAAAACGAAAAGTGGTTGTTGATGATGAATTAGACAATGGTGTACGG
CTCTATTTGAACTTTGGTCATACAATTGGACATGCTGTTGAAAATACTGCAGGCTATGGCAAAGTGATGCATGGAGAAGC
AGTTGCTATCGGGATGGTTCAAATCAGTAAAATTGCCGAACTCAAAGGTCTTATGCCCAAAGGAATTACTGACCAAATTC
GAAAGATGGTCAAAAAATTTGGTTTACCTGACGAATATCAACCTTGGGATGAAGAGCTTTTGTTTAAAGCATTAACTCAT
GATAAAAAAGCACGAGGAAGAATCATCAAAACCGTTATTGTTCCTGAAATTGGCACCGCTAAAATTAATGAAGTGACTTT
TGAAGAAATGAAAGACTATCTCAAAAAATAA

Upstream 100 bases:

>100_bases
GACTTGGCATGCTCATTGGACAGGCGGCGGAAAGCTTTTATTTATGGACAGGTAAAAAAATGCCTGTTGCAGAAATTACA
TTAGAAATGGAGAAAGAAGC

Downstream 100 bases:

>100_bases
CTTGAGTTATTCGGAGAGGAACCCTATCTAAAAATTACAAAAATGTGGTAGCATTAAAAAACTCCCAGCTTTTATAAAAG
CTGTAAAAACACTTATTTAA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKLNVNLPEHPYDVIIENGALANIGTWVSSLWKKQKIVLISDNHVNGLYGQKVVDQLEKVGFEVATFEFPEGEASKNLLT
AENAWNFCAEFGLTRSDGIIALGGGVTGDLAGFVASTYMRGIHFLQIPTSLTAQVDSSIGGKTGINSKMAKNMIGTFTQP
DGVLIDPEVLQTLGQREFREGLGEVIKCALIADKDLWNLLTDLSADDLVKKLDKIEEIIYRSCEVKRKVVVDDELDNGVR
LYLNFGHTIGHAVENTAGYGKVMHGEAVAIGMVQISKIAELKGLMPKGITDQIRKMVKKFGLPDEYQPWDEELLFKALTH
DKKARGRIIKTVIVPEIGTAKINEVTFEEMKDYLKK

Sequences:

>Translated_356_residues
MKLNVNLPEHPYDVIIENGALANIGTWVSSLWKKQKIVLISDNHVNGLYGQKVVDQLEKVGFEVATFEFPEGEASKNLLT
AENAWNFCAEFGLTRSDGIIALGGGVTGDLAGFVASTYMRGIHFLQIPTSLTAQVDSSIGGKTGINSKMAKNMIGTFTQP
DGVLIDPEVLQTLGQREFREGLGEVIKCALIADKDLWNLLTDLSADDLVKKLDKIEEIIYRSCEVKRKVVVDDELDNGVR
LYLNFGHTIGHAVENTAGYGKVMHGEAVAIGMVQISKIAELKGLMPKGITDQIRKMVKKFGLPDEYQPWDEELLFKALTH
DKKARGRIIKTVIVPEIGTAKINEVTFEEMKDYLKK
>Mature_356_residues
MKLNVNLPEHPYDVIIENGALANIGTWVSSLWKKQKIVLISDNHVNGLYGQKVVDQLEKVGFEVATFEFPEGEASKNLLT
AENAWNFCAEFGLTRSDGIIALGGGVTGDLAGFVASTYMRGIHFLQIPTSLTAQVDSSIGGKTGINSKMAKNMIGTFTQP
DGVLIDPEVLQTLGQREFREGLGEVIKCALIADKDLWNLLTDLSADDLVKKLDKIEEIIYRSCEVKRKVVVDDELDNGVR
LYLNFGHTIGHAVENTAGYGKVMHGEAVAIGMVQISKIAELKGLMPKGITDQIRKMVKKFGLPDEYQPWDEELLFKALTH
DKKARGRIIKTVIVPEIGTAKINEVTFEEMKDYLKK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=352, Percent_Identity=35.7954545454545, Blast_Score=207, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6320332, Length=357, Percent_Identity=34.733893557423, Blast_Score=187, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_LACLA (Q9CES8)

Other databases:

- EMBL:   AE005176
- PIR:   D86844
- RefSeq:   NP_267912.1
- ProteinModelPortal:   Q9CES8
- SMR:   Q9CES8
- GeneID:   1115419
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0060
- NMPDR:   fig|272623.1.peg.1800
- HOGENOM:   HBG632303
- OMA:   EHAIATS
- ProtClustDB:   PRK00002
- BioCyc:   LLAC272623:L0060-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39352; Mature: 39352

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNVNLPEHPYDVIIENGALANIGTWVSSLWKKQKIVLISDNHVNGLYGQKVVDQLEKV
CEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC
GFEVATFEFPEGEASKNLLTAENAWNFCAEFGLTRSDGIIALGGGVTGDLAGFVASTYMR
CCEEEEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHC
GIHFLQIPTSLTAQVDSSIGGKTGINSKMAKNMIGTFTQPDGVLIDPEVLQTLGQREFRE
CEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHH
GLGEVIKCALIADKDLWNLLTDLSADDLVKKLDKIEEIIYRSCEVKRKVVVDDELDNGVR
HHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEE
LYLNFGHTIGHAVENTAGYGKVMHGEAVAIGMVQISKIAELKGLMPKGITDQIRKMVKKF
EEEECCCHHHHHHHCCCCCCEEECCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GLPDEYQPWDEELLFKALTHDKKARGRIIKTVIVPEIGTAKINEVTFEEMKDYLKK
CCCCCCCCCHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLNVNLPEHPYDVIIENGALANIGTWVSSLWKKQKIVLISDNHVNGLYGQKVVDQLEKV
CEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC
GFEVATFEFPEGEASKNLLTAENAWNFCAEFGLTRSDGIIALGGGVTGDLAGFVASTYMR
CCEEEEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHC
GIHFLQIPTSLTAQVDSSIGGKTGINSKMAKNMIGTFTQPDGVLIDPEVLQTLGQREFRE
CEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHH
GLGEVIKCALIADKDLWNLLTDLSADDLVKKLDKIEEIIYRSCEVKRKVVVDDELDNGVR
HHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEE
LYLNFGHTIGHAVENTAGYGKVMHGEAVAIGMVQISKIAELKGLMPKGITDQIRKMVKKF
EEEECCCHHHHHHHCCCCCCEEECCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GLPDEYQPWDEELLFKALTHDKKARGRIIKTVIVPEIGTAKINEVTFEEMKDYLKK
CCCCCCCCCHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471