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The map label for this gene is xylM

Identifier: 15673489

GI number: 15673489

Start: 1546480

End: 1547484

Strand: Reverse

Name: xylM

Synonym: L0232

Alternate gene names: 15673489

Gene position: 1547484-1546480 (Counterclockwise)

Preceding gene: 15673490

Following gene: 30024047

Centisome position: 65.42

GC content: 36.22

Gene sequence:

>1005_bases
ATGACATTTACCATTTCCAAAGAATCTTTGCCTTTTAGAGCTGACAAATCAATTAGTCAGATTACATTATCAAATGAACG
ACTCACCATCGTTGTCCATGATTATGGAGCAAGAGTCCATCAACTCCTCACTCCTGACAAAAATGGAACATTTGAAAATA
TTCTTTTATCCAAAAACGATTCCGAAACCTATGCAAATGATGGAGGATATTATGGTGTAATTTGCGGTCCAGTTGCCGGG
CGTATTTCAGGTGCTACTTATGATTCTGTCAGTTTAGAGGCAAATGAAGGAAAAAATAATTTACATTCAGGAAGCCATGG
CTGGGAAAGACAATTTTGGTCTTATGAAACTTTTGAAACAGCATCATCTCTTGGCATTAAACTAAGTTTAAGAGATGAGG
AGTCCGGTTTTCCAGGTCAAATCCAAGCAGAAGTCACTTATAAATTAACTGACAATAAGTTAGAAGTGACAATATCAGGT
CTGTCAGTAACTGACACAGTCTTTAATCCGGCTTGGCATCCTTATTTTAATCTGTCAGCAGAATTATCAACGACTCATGA
GCATTTCATTCAAGCAAATGTTGACTTTCTAGTTGAAACCAATCAAGAGAATATACCAACTGGTCGTCTTCTAACTGTTG
ACGACAGTTCTTATTCAATTAAAGAAAGCGTTTCAATCAAAAAGCTTTTAAAAGATAATCCCGAAGGACTAGATGATTGC
TTTGTTTTTAATCCCAAAGGAGATAAAAGTTTAATGCTTTATGACCCTTTATCTGGTCGGAAACTAGTAGCTCAAACTGA
TAGACAAGCGGTCGTGATTTACACAGCCACAAATCCAGAAATAGAGTCAATGATTAATGGCAGACCAATGTCCAAAAATC
GCGGAATTGCTATTGAATTTCAAGAAATACCTGACCTTGTTCATCATCCTGAATGGGGAACGATTGAGCTTAAAGCAGGT
CAAAAAAAGACTTTTATAACAGAATATCTATTTACAACGAATTAA

Upstream 100 bases:

>100_bases
TAGCACGTTATGAGCAAATTTATCAAATTTGGAAACAAGTTTATAAAAATACCTCTGAAATTTCTCATCAATTAGTAGAA
TTCAATGACGAAGGTTAATT

Downstream 100 bases:

>100_bases
AATTTACTGACAGACTCATCAGTAAAAATAATTTTAATAAAATAATAGGAGGGATGTACTCAAAAATGAGTAATGAAATC
AAACAAGTTCAACATGATGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTFTISKESLPFRADKSISQITLSNERLTIVVHDYGARVHQLLTPDKNGTFENILLSKNDSETYANDGGYYGVICGPVAG
RISGATYDSVSLEANEGKNNLHSGSHGWERQFWSYETFETASSLGIKLSLRDEESGFPGQIQAEVTYKLTDNKLEVTISG
LSVTDTVFNPAWHPYFNLSAELSTTHEHFIQANVDFLVETNQENIPTGRLLTVDDSSYSIKESVSIKKLLKDNPEGLDDC
FVFNPKGDKSLMLYDPLSGRKLVAQTDRQAVVIYTATNPEIESMINGRPMSKNRGIAIEFQEIPDLVHHPEWGTIELKAG
QKKTFITEYLFTTN

Sequences:

>Translated_334_residues
MTFTISKESLPFRADKSISQITLSNERLTIVVHDYGARVHQLLTPDKNGTFENILLSKNDSETYANDGGYYGVICGPVAG
RISGATYDSVSLEANEGKNNLHSGSHGWERQFWSYETFETASSLGIKLSLRDEESGFPGQIQAEVTYKLTDNKLEVTISG
LSVTDTVFNPAWHPYFNLSAELSTTHEHFIQANVDFLVETNQENIPTGRLLTVDDSSYSIKESVSIKKLLKDNPEGLDDC
FVFNPKGDKSLMLYDPLSGRKLVAQTDRQAVVIYTATNPEIESMINGRPMSKNRGIAIEFQEIPDLVHHPEWGTIELKAG
QKKTFITEYLFTTN
>Mature_333_residues
TFTISKESLPFRADKSISQITLSNERLTIVVHDYGARVHQLLTPDKNGTFENILLSKNDSETYANDGGYYGVICGPVAGR
ISGATYDSVSLEANEGKNNLHSGSHGWERQFWSYETFETASSLGIKLSLRDEESGFPGQIQAEVTYKLTDNKLEVTISGL
SVTDTVFNPAWHPYFNLSAELSTTHEHFIQANVDFLVETNQENIPTGRLLTVDDSSYSIKESVSIKKLLKDNPEGLDDCF
VFNPKGDKSLMLYDPLSGRKLVAQTDRQAVVIYTATNPEIESMINGRPMSKNRGIAIEFQEIPDLVHHPEWGTIELKAGQ
KKTFITEYLFTTN

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=330, Percent_Identity=25.4545454545455, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1786971, Length=357, Percent_Identity=26.6106442577031, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17557428, Length=328, Percent_Identity=25.609756097561, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533334, Length=328, Percent_Identity=25.609756097561, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24668278, Length=357, Percent_Identity=28.0112044817927, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24659048, Length=338, Percent_Identity=29.2899408284024, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24583720, Length=325, Percent_Identity=28.9230769230769, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24668282, Length=344, Percent_Identity=22.9651162790698, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641876, Length=351, Percent_Identity=23.6467236467236, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37303; Mature: 37172

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTISKESLPFRADKSISQITLSNERLTIVVHDYGARVHQLLTPDKNGTFENILLSKND
CEEEECCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHCCCCCCCCEEEEEEECCC
SETYANDGGYYGVICGPVAGRISGATYDSVSLEANEGKNNLHSGSHGWERQFWSYETFET
CCCCCCCCCEEEEEECCCCCCCCCCEECEEEEECCCCCCCCCCCCCCCHHHCCCCHHHHH
ASSLGIKLSLRDEESGFPGQIQAEVTYKLTDNKLEVTISGLSVTDTVFNPAWHPYFNLSA
HHHCEEEEEEECCCCCCCCEEEEEEEEEEECCEEEEEEECCEEEHHHCCCCCCCEEEEEE
ELSTTHEHFIQANVDFLVETNQENIPTGRLLTVDDSSYSIKESVSIKKLLKDNPEGLDDC
EECCCCCEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCE
FVFNPKGDKSLMLYDPLSGRKLVAQTDRQAVVIYTATNPEIESMINGRPMSKNRGIAIEF
EEECCCCCCEEEEECCCCCCEEEEECCCCEEEEEECCCCCHHHHHCCCCCCCCCCEEEEH
QEIPDLVHHPEWGTIELKAGQKKTFITEYLFTTN
HHCCHHHHCCCCCEEEEECCCCCEEEEEEEEECC
>Mature Secondary Structure 
TFTISKESLPFRADKSISQITLSNERLTIVVHDYGARVHQLLTPDKNGTFENILLSKND
EEEECCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHCCCCCCCCEEEEEEECCC
SETYANDGGYYGVICGPVAGRISGATYDSVSLEANEGKNNLHSGSHGWERQFWSYETFET
CCCCCCCCCEEEEEECCCCCCCCCCEECEEEEECCCCCCCCCCCCCCCHHHCCCCHHHHH
ASSLGIKLSLRDEESGFPGQIQAEVTYKLTDNKLEVTISGLSVTDTVFNPAWHPYFNLSA
HHHCEEEEEEECCCCCCCCEEEEEEEEEEECCEEEEEEECCEEEHHHCCCCCCCEEEEEE
ELSTTHEHFIQANVDFLVETNQENIPTGRLLTVDDSSYSIKESVSIKKLLKDNPEGLDDC
EECCCCCEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCE
FVFNPKGDKSLMLYDPLSGRKLVAQTDRQAVVIYTATNPEIESMINGRPMSKNRGIAIEF
EEECCCCCCEEEEECCCCCCEEEEECCCCEEEEEECCCCCHHHHHCCCCCCCCCCEEEEH
QEIPDLVHHPEWGTIELKAGQKKTFITEYLFTTN
HHCCHHHHCCCCCEEEEECCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1694527 [H]