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The map label for this gene is tmk

Identifier: 15672380

GI number: 15672380

Start: 403868

End: 404503

Strand: Direct

Name: tmk

Synonym: L3846

Alternate gene names: 15672380

Gene position: 403868-404503 (Clockwise)

Preceding gene: 15672376

Following gene: 15672381

Centisome position: 17.07

GC content: 39.31

Gene sequence:

>636_bases
ATGAATGGAATTCTAATTTCCCTTGAGGGACCCGATGGAGCAGGAAAAACAACGGTTTTAAAAGAAATTTTACCTGAAAT
CCAAAAAATGAAGCGCGAAATTGTCCCAACTCGTGAACCAGGCGGTGTTCGAGTGGCGGAAGAAATTCGCCAAATTATTC
TTGATCCAAAGAATACAGATATTGATTCTAAAACCGAGTTAATGCTTTTTGCGGCGGCGCGTCGTTTACATATGCAAGAA
AAAATGTTGCCAGCTTTACAAGCGGGTAAAGTTGTCATTGTTGACCGATTTATTGATTCATCTGTCGCCTATCAGGGGTA
TGGCCGTGATTTGGGTGTCGAAGTTGTTGATTGGCTTAACTATTTTGCAACAGATGGGTTGAAGCCTGATTTGACGCTTT
ATTTTGATGTTGATACGGATGTTGCCCTTGAGCGAATTATGAAAAATCGAGCTGATGAGGTAAATCGTTTAGATTTGGAA
AGAGCTGAGATGCATCGTAAAGTTCGTGAAGGTTATTTGGAGATTGTTGTAAAAGAACCTGAGCGTTTTGTAAAAATAGA
TGCAAGTCAACCTTTAGAAAAAGTGGTAGCTGATACACTTTCCGTCCTCAAAAAAAGATTTGTCAGTGAATTTTAA

Upstream 100 bases:

>100_bases
TCAGTTATATTATACAATTTTTAGTAAAATTACGCAAAAAGAGACCCTATTATTTTTAGAAAAAAGATAAAATATTTGTT
TTTTTGGTATAATAGAGGCT

Downstream 100 bases:

>100_bases
AGACAATTTAATCTGTCAGCAAAATTAAGAATGCTAAAAAATACTTACATTTTTCAAAAAATGAGGATGTTAAATAGTTT
TTTTAATTTTGTTATTTAGA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MNGILISLEGPDGAGKTTVLKEILPEIQKMKREIVPTREPGGVRVAEEIRQIILDPKNTDIDSKTELMLFAAARRLHMQE
KMLPALQAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLNYFATDGLKPDLTLYFDVDTDVALERIMKNRADEVNRLDLE
RAEMHRKVREGYLEIVVKEPERFVKIDASQPLEKVVADTLSVLKKRFVSEF

Sequences:

>Translated_211_residues
MNGILISLEGPDGAGKTTVLKEILPEIQKMKREIVPTREPGGVRVAEEIRQIILDPKNTDIDSKTELMLFAAARRLHMQE
KMLPALQAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLNYFATDGLKPDLTLYFDVDTDVALERIMKNRADEVNRLDLE
RAEMHRKVREGYLEIVVKEPERFVKIDASQPLEKVVADTLSVLKKRFVSEF
>Mature_211_residues
MNGILISLEGPDGAGKTTVLKEILPEIQKMKREIVPTREPGGVRVAEEIRQIILDPKNTDIDSKTELMLFAAARRLHMQE
KMLPALQAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLNYFATDGLKPDLTLYFDVDTDVALERIMKNRADEVNRLDLE
RAEMHRKVREGYLEIVVKEPERFVKIDASQPLEKVVADTLSVLKKRFVSEF

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=215, Percent_Identity=35.8139534883721, Blast_Score=112, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_LACLA (Q9CIG4)

Other databases:

- EMBL:   AE005176
- PIR:   F86674
- RefSeq:   NP_266554.1
- ProteinModelPortal:   Q9CIG4
- SMR:   Q9CIG4
- GeneID:   1114009
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L3846
- NMPDR:   fig|272623.1.peg.406
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   LLAC272623:L3846-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23999; Mature: 23999

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGILISLEGPDGAGKTTVLKEILPEIQKMKREIVPTREPGGVRVAEEIRQIILDPKNTD
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCC
IDSKTELMLFAAARRLHMQEKMLPALQAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCHHHHCCCCCCCCHHHHHHHH
YFATDGLKPDLTLYFDVDTDVALERIMKNRADEVNRLDLERAEMHRKVREGYLEIVVKEP
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
ERFVKIDASQPLEKVVADTLSVLKKRFVSEF
HHEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGILISLEGPDGAGKTTVLKEILPEIQKMKREIVPTREPGGVRVAEEIRQIILDPKNTD
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCC
IDSKTELMLFAAARRLHMQEKMLPALQAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCHHHHCCCCCCCCHHHHHHHH
YFATDGLKPDLTLYFDVDTDVALERIMKNRADEVNRLDLERAEMHRKVREGYLEIVVKEP
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
ERFVKIDASQPLEKVVADTLSVLKKRFVSEF
HHEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471