Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 15672376

GI number: 15672376

Start: 398897

End: 400525

Strand: Direct

Name: groEL

Synonym: L198893

Alternate gene names: 15672376

Gene position: 398897-400525 (Clockwise)

Preceding gene: 15672375

Following gene: 15672380

Centisome position: 16.86

GC content: 39.04

Gene sequence:

>1629_bases
ATGTCAAAAGATATTAAATTTTCAAGTGATGCTAGAACAGCGATGATGCGTGGGATTGATATTCTTGCTGATACAGTAAA
AACAACCCTTGGACCAAAAGGTCGCAATGTTGTTCTTGAAAAATCATATGGATCACCTTTAATTACAAACGATGGTGTAA
CGATTGCCAAAGAGATTGAACTTGAAGATCATTTTGAAAATATGGGAGCTAAACTTGTTTCAGAAGTTGCTTCAAAAACA
AATGATATCGCAGGTGACGGTACAACAACAGCGACAGTTTTGACACAAGCTATCGTTCGTGAAGGTTTAAAAAATGTTAC
CGCAGGTGCAAATCCAGTTGGTATTCGCCGAGGAATTGAACTTGCTGCTGAAACAGCTGTTGCGTCAATTAAAGAGATGG
CAATTCCTGTCCACGATAAATCAGCAATTGCGCAAGTAGCTACCGTTTCATCACGTAGTGAAAAAGTGGGTGAGTATATT
TCTGATGCAATGGAACGTGTAGGTTCTGACGGAGTTATCACCATTGAAGAATCAAAAGGGATGCAAACTGAACTCGATGT
TGTTGAAGGAATGCAATTTGACCGTGGATATTTGAGTCAATATATGGTTTCTAATACAGAAAAAATGGTTGCTGAATTAG
ATAATCCTTATATTCTTATTACCGACAAAAAAATCTCAAACATTCAAGAAATTTTACCGCTCCTTGAACAAATCTTGAAA
ACAAATCGTCCACTTCTTATTGTAGCTGATGATGTTGATGGAGAAGCATTGCCAACGCTTGTTCTTAATAAGATTAAAGG
TGTCTTCAATGTTGTAGCTGTAAAAGCACCAGGATTTGGTGATCGTCGTAAAGCTCAATTGGAAGATTTGGCTATCTTGA
CAGGTGGTACAGTAATTACTGAAGAACTTGGTCTTGATCTTAAAGATGCTACTCTTGAAGCTTTAGGACAAGCAGCTAAG
GCAACTGTGGATAAAGACCACACAACAATTGTTGAAGGTGCTGGTTCTGCTGATGCTATTTCTGATCGTGTAGCTATTAT
TAAAGCGCAAATTGAAAAAACAACTTCTGATTTTGATCGTGAAAAATTACAAGAACGTCTTGCAAAATTAGCTGGTGGTG
TTGCAGTTGTTAAAGTTGGTGCTGCAACTGAAACAGAGCTCAAAGCAATGAAACTCTTGATTGAAGATGCACTTAATGCA
ACACGTGCAGCCGTTGAGGAAGGTATTGTTTCTGGTGGTGGTACAGCACTTGTTAATGCTATTGCTGCTTTGGATAAACT
TTCAGAAGAAGGAGATATTCAAACAGGTATTAACATTGTTCGCCGTGCTCTTGAAGAACCAGTTCGTCAAATTGCTGCCA
ATGCAGGATATGAAGGTTCAGTTATCATTGATAAACTTCGTTCAGAAGAAGTAGGTACAGGATTCAATGCTGCAACTGGT
CAATGGGTTAATATGATTGAAGAAGGAATTGTTGACCCTGCAAAAGTAACTCGTTCAGCTTTGCAAAACGCGGCTTCTGT
TGCTGGTTTAATTTTGACTACTGAAGCAGTAGTTGCTAATAAGCCAGAACCAGCTGCTCCAGCTATGCCTCCAATGGACC
CTAGCATGGGAATGGGTGGTATGATGTAA

Upstream 100 bases:

>100_bases
AATTGTAGAGTAAAATTATAAAAGCAATCATTTTTTTGGTTGTCTTTTGTCTATCTTAAAATCTATAAAATTAAAAATAT
ATTCTTAAAAAGGAGCTAAA

Downstream 100 bases:

>100_bases
TAAAAAAGAACCCTTAGGGTTCTTTTTTTATTTGCTGATGAGTAACTAAATATCGTAAAGTTGACTAGCATGTTCGTGAC
TAGTATCAAGGATCTTCAAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYI
SDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAK
ATVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNA
TRAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATG
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM

Sequences:

>Translated_542_residues
MSKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYI
SDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAK
ATVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNA
TRAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATG
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM
>Mature_541_residues
SKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTN
DIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYIS
DAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILKT
NRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAKA
TVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNAT
RAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATGQ
WVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=50.6666666666667, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=50.6666666666667, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI5453607, Length=543, Percent_Identity=23.7569060773481, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI302058290, Length=512, Percent_Identity=21.6796875, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI38455427, Length=562, Percent_Identity=23.6654804270463, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI58331173, Length=544, Percent_Identity=20.9558823529412, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI4502643, Length=547, Percent_Identity=22.1206581352834, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=59.7328244274809, Blast_Score=627, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=48.3018867924528, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=47.3684210526316, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17564182, Length=563, Percent_Identity=23.8010657193606, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=30.635838150289, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322350, Length=556, Percent_Identity=23.5611510791367, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=113, Percent_Identity=34.5132743362832, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320058, Length=167, Percent_Identity=28.7425149700599, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=539, Percent_Identity=22.6345083487941, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=49.3333333333333, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=49.3333333333333, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=46.7557251908397, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=46.7557251908397, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=46.7557251908397, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=42.6386233269598, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=34.9532710280374, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=34.9532710280374, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24645179, Length=511, Percent_Identity=24.0704500978474, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24652903, Length=174, Percent_Identity=30.4597701149425, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647245, Length=174, Percent_Identity=30.4597701149425, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583944, Length=187, Percent_Identity=26.7379679144385, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_LACLA (P37282)

Other databases:

- EMBL:   X71132
- EMBL:   AE005176
- PIR:   B86674
- PIR:   JN0661
- PIR:   S32106
- RefSeq:   NP_266550.1
- ProteinModelPortal:   P37282
- SMR:   P37282
- PhosSite:   P37282
- GeneID:   1114005
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L198893
- NMPDR:   fig|272623.1.peg.402
- HOGENOM:   HBG625289
- OMA:   DVKFHDS
- ProtClustDB:   PRK00013
- BioCyc:   LLAC272623:L198893-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57202; Mature: 57071

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHEEEEECCEEEH
EELGLDLKDATLEALGQAAKATVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDR
HHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNATRAAVEEGIVSGGGTALVNA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHCCCCCCCCCH
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MM
CC
>Mature Secondary Structure 
SKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHEEEEECCEEEH
EELGLDLKDATLEALGQAAKATVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDR
HHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNATRAAVEEGIVSGGGTALVNA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHCCCCCCCCCH
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8486277; 11337471