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The map label for this gene is pgsA1

Identifier: 15607095

GI number: 15607095

Start: 1518607

End: 1519143

Strand: Direct

Name: pgsA1

Synonym: aq_2154

Alternate gene names: 15607095

Gene position: 1518607-1519143 (Clockwise)

Preceding gene: 15607094

Following gene: 15607096

Centisome position: 97.89

GC content: 33.15

Gene sequence:

>537_bases
ATGAACGTTCCCAATCTGCTGAGCTTATCTAGACTCATACTTTCCCCCTTAATTCTTTACTTCGTTTTAGAAGAAAATTA
CTTAAGTTCTTTAGTCTTAGTCCTTTTTTTAGCTTTAATGGATTTTCTCGACGGATTTTTTGCAAGAAAGTTAAACCAGA
GTACCAGAATGGGGAAAATTCTGGACCCTTTAGCGGATAAAGTATTTACTTTCTTCTCACTCCTTTCTTACACCTTCTTT
TCAAAAGAAAGATTAAATCCTTTGATATTTTTTCTGCTTTTGGGAAGGGATATAACTTTAATAATTGGGGGAATATTTCT
AATAAAAAGGAAATTTACCCCTGAACCATCAATCTACGGAAAATTCACGACACTTTTCGTGTCTTTGAGTCTTTTGAGTG
TCGGGATTTTAAACGTTTACGATGTGAATTTTTTACGGATTTTGACAAATGTTTTAGAAATCGTTTCATTAATCCTGATA
CTTGTATCCTGGGTGGATTACACACTTAAGGGCTTTAAAATGATTTTTAAGGAATGA

Upstream 100 bases:

>100_bases
AGACCAAAGTACCCCTTCAAGCCTGCAGAAGATGCCGTTATTATAGATACGACCAGAAAAAGCGTTGAAGAAGTGGTCGA
AGAAGTCTTAAAGATTATCC

Downstream 100 bases:

>100_bases
AAGGTGTTAAAGGAAGAAGGTGGGTACTCCTCTACAGAGAAAAAGAACCGCCTAGTTTTCTAGTTGAAAAGTACGGAAGA
ATTCTAGCCCAGCTTATCAC

Product: phosphotidylglycerophosphate synthase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MNVPNLLSLSRLILSPLILYFVLEENYLSSLVLVLFLALMDFLDGFFARKLNQSTRMGKILDPLADKVFTFFSLLSYTFF
SKERLNPLIFFLLLGRDITLIIGGIFLIKRKFTPEPSIYGKFTTLFVSLSLLSVGILNVYDVNFLRILTNVLEIVSLILI
LVSWVDYTLKGFKMIFKE

Sequences:

>Translated_178_residues
MNVPNLLSLSRLILSPLILYFVLEENYLSSLVLVLFLALMDFLDGFFARKLNQSTRMGKILDPLADKVFTFFSLLSYTFF
SKERLNPLIFFLLLGRDITLIIGGIFLIKRKFTPEPSIYGKFTTLFVSLSLLSVGILNVYDVNFLRILTNVLEIVSLILI
LVSWVDYTLKGFKMIFKE
>Mature_178_residues
MNVPNLLSLSRLILSPLILYFVLEENYLSSLVLVLFLALMDFLDGFFARKLNQSTRMGKILDPLADKVFTFFSLLSYTFF
SKERLNPLIFFLLLGRDITLIIGGIFLIKRKFTPEPSIYGKFTTLFVSLSLLSVGILNVYDVNFLRILTNVLEIVSLILI
LVSWVDYTLKGFKMIFKE

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

Organism=Homo sapiens, GI188536108, Length=123, Percent_Identity=32.520325203252, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI10092647, Length=123, Percent_Identity=32.520325203252, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1788220, Length=70, Percent_Identity=44.2857142857143, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71984838, Length=106, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984834, Length=106, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320059, Length=108, Percent_Identity=38.8888888888889, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650130, Length=127, Percent_Identity=29.9212598425197, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24650126, Length=127, Percent_Identity=29.9212598425197, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24650128, Length=127, Percent_Identity=29.9212598425197, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA_AQUAE (O67908)

Other databases:

- EMBL:   AE000657
- PIR:   H70484
- RefSeq:   NP_214477.1
- GeneID:   1193897
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_2154
- NMPDR:   fig|224324.1.peg.1492
- OMA:   HRVIPVA
- ProtClustDB:   CLSK2748567
- BioCyc:   AAEO224324:AQ_2154-MONOMER
- BRENDA:   2.7.8.5
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 20482; Mature: 20482

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc315260)-; HASH(0xe677480)-; HASH(0xedb3fb8)-; HASH(0xecace20)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPNLLSLSRLILSPLILYFVLEENYLSSLVLVLFLALMDFLDGFFARKLNQSTRMGKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LDPLADKVFTFFSLLSYTFFSKERLNPLIFFLLLGRDITLIIGGIFLIKRKFTPEPSIYG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHH
KFTTLFVSLSLLSVGILNVYDVNFLRILTNVLEIVSLILILVSWVDYTLKGFKMIFKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MNVPNLLSLSRLILSPLILYFVLEENYLSSLVLVLFLALMDFLDGFFARKLNQSTRMGKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LDPLADKVFTFFSLLSYTFFSKERLNPLIFFLLLGRDITLIIGGIFLIKRKFTPEPSIYG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHH
KFTTLFVSLSLLSVGILNVYDVNFLRILTNVLEIVSLILILVSWVDYTLKGFKMIFKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320