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The map label for this gene is tyrP_1 [H]

Identifier: 15602597

GI number: 15602597

Start: 860624

End: 861835

Strand: Direct

Name: tyrP_1 [H]

Synonym: PM0732

Alternate gene names: 15602597

Gene position: 860624-861835 (Clockwise)

Preceding gene: 15602590

Following gene: 15602599

Centisome position: 38.12

GC content: 40.26

Gene sequence:

>1212_bases
ATGAAAAATAAAACCTTTGGAAGCGCATTATTAGTTGCGGGAACCACCATCGGTGCCGGCATGCTTGCTATGCCATTAAC
CTCGGCCGAAATGGGCTTTACTTACACGTTAATTCTATTATTTATCCTATGGGGACTGCTCTCTTATAGTGCGTTACTTT
TTGTTGAAGTTTACCAAAAAGCAGAAACCAAAAATGCTGGAATCGCTACCCTTGCGGAACAATATTTTGGCTTACCGGGA
CGTATTTTAGCTACCTTATCACTTGTCGTTTTTATGTACGCGATTTTATCAGCCTATGTCACAGGGGGCGGTTCACTTTT
AGCCGGTGTCCTTCCTTTTTTAGGTGAGCATGCCACACCAATTTCTATCGTTTCTTTCACGATTGTCCTTGGGGTATTTA
TTGTGATCAGTACAGGCGCAGTAGATATGCTCACACGCTTCCTATTTATGATTAAGTTAGTGGCTTTTGTGTTTGTCTTA
TTGATGATGTTACCTTTGGTCAATGGCGATAACTTACTGGCAATGCCATTAAAAGATTTTTTAATTATTTCTGCCAGTCC
CGTATTTTTTACCTCTTTTGGTTTCCATGTCATCATTCCAAGTATTAACAGCTATTTAGACGGCAATATTCGTCGTTTAC
GTATTGCAATTATTACGGGGACAGCGATTCCTTTAGTGGCTTACATTATTTGGCAATTAGCCACTCATGGTGTTTTCCCA
CAAGCCCAGTTCGTACAAATTTTAAACACTGACCCTACTTTAAATGGTTTAATCACGGCGACTTACCAAGCTACAGAAAG
CGCTATTATCAGCCATGCGATGCGTTTATTCTTTACCTTAGCACTGATTACGTCTTTCTTGGGTGTCGCGTTATCTTTAT
TCGATTGTTTATACGATTTACTTAAACGAGTAAAAATCAAAACAAACCGTGTGTCGCTAGGTTTACTTACCTTCTTACCC
CCATTAATTTTTGCGTTGTTCTACCCTGAGGGTTTTGTCATGGCATTAGGTTATGCGGGGCAAATGTTTACCTTTTACGG
TTTAGTATTACCTGTTGGCATGGCATGGCGTGCTAGAAAACGTTATCCGGATCTACCATATCGTGTCATGGGAGGCAACC
TTACCTTATTCGGTGCCTTAATCTTAGGTATCTTGATTATGAATGTGCCTTTCTTAATCAAAGCCGGTTATCTCCCTGCT
GTTATTGGTTAA

Upstream 100 bases:

>100_bases
TGTAAAATAATAATAACACTGTAAAAAAATGGTTACATTCAGTGTTTTTTTCCGTTAGAATGCGGTTTGCTTATTCATTT
ACGTTTTTTGAGAGTAATTT

Downstream 100 bases:

>100_bases
TTCACATAAGCAATCACATAAGTGAAAGGCGAACCATTGAGGTTCGCCTTTTACTTTATTTCAACCAAGTCGTTATTTCC
GTTAAAGGCTTACGTGATTT

Product: TyrP

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1 [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKNKTFGSALLVAGTTIGAGMLAMPLTSAEMGFTYTLILLFILWGLLSYSALLFVEVYQKAETKNAGIATLAEQYFGLPG
RILATLSLVVFMYAILSAYVTGGGSLLAGVLPFLGEHATPISIVSFTIVLGVFIVISTGAVDMLTRFLFMIKLVAFVFVL
LMMLPLVNGDNLLAMPLKDFLIISASPVFFTSFGFHVIIPSINSYLDGNIRRLRIAIITGTAIPLVAYIIWQLATHGVFP
QAQFVQILNTDPTLNGLITATYQATESAIISHAMRLFFTLALITSFLGVALSLFDCLYDLLKRVKIKTNRVSLGLLTFLP
PLIFALFYPEGFVMALGYAGQMFTFYGLVLPVGMAWRARKRYPDLPYRVMGGNLTLFGALILGILIMNVPFLIKAGYLPA
VIG

Sequences:

>Translated_403_residues
MKNKTFGSALLVAGTTIGAGMLAMPLTSAEMGFTYTLILLFILWGLLSYSALLFVEVYQKAETKNAGIATLAEQYFGLPG
RILATLSLVVFMYAILSAYVTGGGSLLAGVLPFLGEHATPISIVSFTIVLGVFIVISTGAVDMLTRFLFMIKLVAFVFVL
LMMLPLVNGDNLLAMPLKDFLIISASPVFFTSFGFHVIIPSINSYLDGNIRRLRIAIITGTAIPLVAYIIWQLATHGVFP
QAQFVQILNTDPTLNGLITATYQATESAIISHAMRLFFTLALITSFLGVALSLFDCLYDLLKRVKIKTNRVSLGLLTFLP
PLIFALFYPEGFVMALGYAGQMFTFYGLVLPVGMAWRARKRYPDLPYRVMGGNLTLFGALILGILIMNVPFLIKAGYLPA
VIG
>Mature_403_residues
MKNKTFGSALLVAGTTIGAGMLAMPLTSAEMGFTYTLILLFILWGLLSYSALLFVEVYQKAETKNAGIATLAEQYFGLPG
RILATLSLVVFMYAILSAYVTGGGSLLAGVLPFLGEHATPISIVSFTIVLGVFIVISTGAVDMLTRFLFMIKLVAFVFVL
LMMLPLVNGDNLLAMPLKDFLIISASPVFFTSFGFHVIIPSINSYLDGNIRRLRIAIITGTAIPLVAYIIWQLATHGVFP
QAQFVQILNTDPTLNGLITATYQATESAIISHAMRLFFTLALITSFLGVALSLFDCLYDLLKRVKIKTNRVSLGLLTFLP
PLIFALFYPEGFVMALGYAGQMFTFYGLVLPVGMAWRARKRYPDLPYRVMGGNLTLFGALILGILIMNVPFLIKAGYLPA
VIG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=407, Percent_Identity=48.6486486486487, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790145, Length=384, Percent_Identity=29.4270833333333, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789552, Length=360, Percent_Identity=26.9444444444444, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43884; Mature: 43884

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKTFGSALLVAGTTIGAGMLAMPLTSAEMGFTYTLILLFILWGLLSYSALLFVEVYQK
CCCCCCCCCHHEECCHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AETKNAGIATLAEQYFGLPGRILATLSLVVFMYAILSAYVTGGGSLLAGVLPFLGEHATP
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCH
ISIVSFTIVLGVFIVISTGAVDMLTRFLFMIKLVAFVFVLLMMLPLVNGDNLLAMPLKDF
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHH
LIISASPVFFTSFGFHVIIPSINSYLDGNIRRLRIAIITGTAIPLVAYIIWQLATHGVFP
EEEECCCHHHHCCCCEEEECCHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCC
QAQFVQILNTDPTLNGLITATYQATESAIISHAMRLFFTLALITSFLGVALSLFDCLYDL
CHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRVKIKTNRVSLGLLTFLPPLIFALFYPEGFVMALGYAGQMFTFYGLVLPVGMAWRARK
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHC
RYPDLPYRVMGGNLTLFGALILGILIMNVPFLIKAGYLPAVIG
CCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKNKTFGSALLVAGTTIGAGMLAMPLTSAEMGFTYTLILLFILWGLLSYSALLFVEVYQK
CCCCCCCCCHHEECCHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AETKNAGIATLAEQYFGLPGRILATLSLVVFMYAILSAYVTGGGSLLAGVLPFLGEHATP
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCH
ISIVSFTIVLGVFIVISTGAVDMLTRFLFMIKLVAFVFVLLMMLPLVNGDNLLAMPLKDF
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHH
LIISASPVFFTSFGFHVIIPSINSYLDGNIRRLRIAIITGTAIPLVAYIIWQLATHGVFP
EEEECCCHHHHCCCCEEEECCHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCC
QAQFVQILNTDPTLNGLITATYQATESAIISHAMRLFFTLALITSFLGVALSLFDCLYDL
CHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRVKIKTNRVSLGLLTFLPPLIFALFYPEGFVMALGYAGQMFTFYGLVLPVGMAWRARK
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHC
RYPDLPYRVMGGNLTLFGALILGILIMNVPFLIKAGYLPAVIG
CCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]