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The map label for this gene is htrA [C]

Identifier: 15602599

GI number: 15602599

Start: 862776

End: 864155

Strand: Direct

Name: htrA [C]

Synonym: PM0734

Alternate gene names: 15602599

Gene position: 862776-864155 (Clockwise)

Preceding gene: 15602597

Following gene: 15602601

Centisome position: 38.22

GC content: 42.25

Gene sequence:

>1380_bases
ATGAGAAAAAGACGTTTTCTATTAACAAGTATTGCACTCGGATTAAGCATTTTATCGACGCCGATGATAAGTCAAGCGTC
CTTACCAACTCAAGTTGACGGTCAGCAAGTCCCTAGCCTCGCCCCTATGTTAGAAAAAGTCTTACCAGCGGTGGTATCTA
TTTCTGTGGAAGGGAAAGCCAAGAATCATGGTAGTACACCATTTCAAGGTATCCCAGAAGAATTTCGTTTTTTCTTTGGT
CCCGATCTTTTCAATGATCGCGCACCACGTAATTTCCGTGGTATCGGCTCAGGCGTCATCATTAACGCTGAAAAAGGTTA
TGTGTTAACGAATAATCACGTCATTGACAGTGCAGATAAAATCACCGTGCAGTTACAAGATGGTCGAGAGTTAAGCGCAA
AAGTGATTGGTACTGATGAATTATCTGATGTTGCACTGATTCAAATTGAAAAACCCAAAAATTTGACCGCACTAACGATT
GCTGATTCCGATAAACTCCGCGTTGGCGATTTTACTGTAGCTATTGGTAATCCTTTTGGCTTGGGACAAACCGTGACATC
TGGTATCGTCTCTGCCTTAGGTCGTTCAACGGGTTCAGATAACGGTACGTATGAAAACTATATCCAAACTGATGCCGCAG
TAAACCGCGGAAATTCAGGAGGTCCTTTAATCAACCTACAAGGAGAGCTAATTGGTATTAATACTGCGATTATTTCACCA
AGTGGGGGAAATGCCGGCATTGCTTTTGCAATTCCAAGTAATATGGCAAATAACTTAGTACAACAAATTTTAGAATTCGG
TGAAGTACGTCGTGGCATGCTAGGCATTAAAGGGGGCGAGCTCAACGCGGATCTAGCGAAAGCTTTTGATATTGAAGCTC
AACAAGGGGCATTTGTAAGTGAAGTCTTGCCTAATTCTGCTGCAGAAAAAGCCGGTTTAAAAGCAGGTGATGTCATTGTC
GCGATGAATGGTCAGAAAATTTCCAGTTTTGCTGAAATGCGAGCAAAGATCGCGACATCTGGTGCAGGGAAAGAAATTGC
TCTCACCTATCTACGCGACGGTAAAACACATCAAACAAAGGTCACATTACAATCAGATGATCAAACTCAAGCCGATGCAA
GTCACTTATTACCGGCATTAGCTGGGGCTGAGATGAGCAATCATGATGATAAAGGCGTCAAAGGCGTACTCATCACGAGT
GTGACACCTAAATCGCTTGCAGAACAACGTGGTTTGAAAAAGGGCGATGTCATCATTGGGGTGAACCGTCAAAAAGTAGA
AAATTTAGGTCAACTGCGTAAAATTTTAGATGCAAAACCTTCGGCGATTGCTCTAAATATTGTGCGTGGCAATACGAATT
TCTATCTTCTTATTCAATAA

Upstream 100 bases:

>100_bases
TTTCATTTCGTCGAACATTTCTGCATTTTCTTTGTCTTATGTGATACCTAAATCATTCGACTCGGTTTAGTGTGTTTGAC
ATTTATTGGAGAAAATAACA

Downstream 100 bases:

>100_bases
CTCGAGTACAAAATAAATCAGGGGATACACAATTGTATCCCCTCTATTTTTAGCGTGCGGAAAAAACGAAAAAAGTCACC
GCACTTTTACCAATAACTAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRKRRFLLTSIALGLSILSTPMISQASLPTQVDGQQVPSLAPMLEKVLPAVVSISVEGKAKNHGSTPFQGIPEEFRFFFG
PDLFNDRAPRNFRGIGSGVIINAEKGYVLTNNHVIDSADKITVQLQDGRELSAKVIGTDELSDVALIQIEKPKNLTALTI
ADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDNGTYENYIQTDAAVNRGNSGGPLINLQGELIGINTAIISP
SGGNAGIAFAIPSNMANNLVQQILEFGEVRRGMLGIKGGELNADLAKAFDIEAQQGAFVSEVLPNSAAEKAGLKAGDVIV
AMNGQKISSFAEMRAKIATSGAGKEIALTYLRDGKTHQTKVTLQSDDQTQADASHLLPALAGAEMSNHDDKGVKGVLITS
VTPKSLAEQRGLKKGDVIIGVNRQKVENLGQLRKILDAKPSAIALNIVRGNTNFYLLIQ

Sequences:

>Translated_459_residues
MRKRRFLLTSIALGLSILSTPMISQASLPTQVDGQQVPSLAPMLEKVLPAVVSISVEGKAKNHGSTPFQGIPEEFRFFFG
PDLFNDRAPRNFRGIGSGVIINAEKGYVLTNNHVIDSADKITVQLQDGRELSAKVIGTDELSDVALIQIEKPKNLTALTI
ADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDNGTYENYIQTDAAVNRGNSGGPLINLQGELIGINTAIISP
SGGNAGIAFAIPSNMANNLVQQILEFGEVRRGMLGIKGGELNADLAKAFDIEAQQGAFVSEVLPNSAAEKAGLKAGDVIV
AMNGQKISSFAEMRAKIATSGAGKEIALTYLRDGKTHQTKVTLQSDDQTQADASHLLPALAGAEMSNHDDKGVKGVLITS
VTPKSLAEQRGLKKGDVIIGVNRQKVENLGQLRKILDAKPSAIALNIVRGNTNFYLLIQ
>Mature_459_residues
MRKRRFLLTSIALGLSILSTPMISQASLPTQVDGQQVPSLAPMLEKVLPAVVSISVEGKAKNHGSTPFQGIPEEFRFFFG
PDLFNDRAPRNFRGIGSGVIINAEKGYVLTNNHVIDSADKITVQLQDGRELSAKVIGTDELSDVALIQIEKPKNLTALTI
ADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDNGTYENYIQTDAAVNRGNSGGPLINLQGELIGINTAIISP
SGGNAGIAFAIPSNMANNLVQQILEFGEVRRGMLGIKGGELNADLAKAFDIEAQQGAFVSEVLPNSAAEKAGLKAGDVIV
AMNGQKISSFAEMRAKIATSGAGKEIALTYLRDGKTHQTKVTLQSDDQTQADASHLLPALAGAEMSNHDDKGVKGVLITS
VTPKSLAEQRGLKKGDVIIGVNRQKVENLGQLRKILDAKPSAIALNIVRGNTNFYLLIQ

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=305, Percent_Identity=37.0491803278689, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI22129776, Length=317, Percent_Identity=35.0157728706625, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI24308541, Length=308, Percent_Identity=33.1168831168831, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI7019477, Length=263, Percent_Identity=35.361216730038, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1789629, Length=462, Percent_Identity=58.2251082251082, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1786356, Length=446, Percent_Identity=57.1748878923767, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=39.8550724637681, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=33.1058020477816, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 48534; Mature: 48534

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRRFLLTSIALGLSILSTPMISQASLPTQVDGQQVPSLAPMLEKVLPAVVSISVEGKA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCC
KNHGSTPFQGIPEEFRFFFGPDLFNDRAPRNFRGIGSGVIINAEKGYVLTNNHVIDSADK
CCCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCEEECCCCE
ITVQLQDGRELSAKVIGTDELSDVALIQIEKPKNLTALTIADSDKLRVGDFTVAIGNPFG
EEEEEECCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCEEECEEEEEECCCCC
LGQTVTSGIVSALGRSTGSDNGTYENYIQTDAAVNRGNSGGPLINLQGELIGINTAIISP
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHCCCCCCCCEEEECCEEEEEEEEEEEC
SGGNAGIAFAIPSNMANNLVQQILEFGEVRRGMLGIKGGELNADLAKAFDIEAQQGAFVS
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCCCCCCCHHH
EVLPNSAAEKAGLKAGDVIVAMNGQKISSFAEMRAKIATSGAGKEIALTYLRDGKTHQTK
HHCCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEE
VTLQSDDQTQADASHLLPALAGAEMSNHDDKGVKGVLITSVTPKSLAEQRGLKKGDVIIG
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCEEEE
VNRQKVENLGQLRKILDAKPSAIALNIVRGNTNFYLLIQ
CCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MRKRRFLLTSIALGLSILSTPMISQASLPTQVDGQQVPSLAPMLEKVLPAVVSISVEGKA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCC
KNHGSTPFQGIPEEFRFFFGPDLFNDRAPRNFRGIGSGVIINAEKGYVLTNNHVIDSADK
CCCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCEEECCCCE
ITVQLQDGRELSAKVIGTDELSDVALIQIEKPKNLTALTIADSDKLRVGDFTVAIGNPFG
EEEEEECCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCEEECEEEEEECCCCC
LGQTVTSGIVSALGRSTGSDNGTYENYIQTDAAVNRGNSGGPLINLQGELIGINTAIISP
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHCCCCCCCCEEEECCEEEEEEEEEEEC
SGGNAGIAFAIPSNMANNLVQQILEFGEVRRGMLGIKGGELNADLAKAFDIEAQQGAFVS
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCCCCCCCHHH
EVLPNSAAEKAGLKAGDVIVAMNGQKISSFAEMRAKIATSGAGKEIALTYLRDGKTHQTK
HHCCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEE
VTLQSDDQTQADASHLLPALAGAEMSNHDDKGVKGVLITSVTPKSLAEQRGLKKGDVIIG
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCEEEE
VNRQKVENLGQLRKILDAKPSAIALNIVRGNTNFYLLIQ
CCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]