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The map label for this gene is lldD [H]

Identifier: 15602153

GI number: 15602153

Start: 328496

End: 329662

Strand: Reverse

Name: lldD [H]

Synonym: PM0288

Alternate gene names: 15602153

Gene position: 329662-328496 (Counterclockwise)

Preceding gene: 15602154

Following gene: 15602151

Centisome position: 14.6

GC content: 45.42

Gene sequence:

>1167_bases
ATGAAAGATTTATCAAAAATGACCTGCCTTGAAGACTTACGCCGTGTTGCGCAACGTAAAGTGCCAAAAATGTTTTATGA
CTATGTAGTTTCAGGATCTTGGAGCGAAAGCACATTGCATGCCAACCGTAATGATTTTCAAGCAATTAAGCTACGTCAAC
GTGTTTTAGTGGATATGGAAGGTCGCTCACTGGAAAGCACAATGATTGGTCAACAAGTCAAAATGCCATTAGCCATTGCG
CCAACCGGCTTTACTGGCATGGTTCACCCCGACGGTGAAATCCATGCGGCGCGTGCGGCAGAAAAATTTGGCATTCCCTT
TTCTCTATCGACCATGTCCATCTGTTCTATTGAAGATGTGGCAGAGCATACGAGCGCACCATTTTGGTTTCAACTCTATG
TCATGCGTGATCGTGAGTTCATGCGCAATTTGATTAAACGTGCACAAGCAGCCAAATGCTCTGCACTGATTCTGACAGCC
GATCTGCAAGTGCTCGGACAGCGCCATCGTGATATCAAAAATGGCTTATCCGCCCCACCTAAACCCACTTTAAGAAACTG
GATAAATCTTGCCACCAAATTGGAATGGAGCTTAAAAATGCTCGGTACACAACGCCGTACTTTCCGTAATATTGTCGGTC
ATGCCAAAAATGTTGGCGATTTATCCTCACTCACTTCATGGACCTCAGAACAATTTGATCCGCGTTTAAGCTGGGATGAT
GTGGCAGAAATTAAAGCATTATGGGGAGGTAAACTCATCATTAAAGGGATAATGGAACCAGAAGATGCCGAAATGGCGGT
GAAATCCGGTGCTGATGCCATTGTGGTATCCAACCATGGTGGTCGTCAGCTAGATGGTGCGTTATCCTCGATTCAAGCCT
TGCCAAATATAGTGAGTGCCGTAGGGAACGAGATTGAAGTCTGGCTAGACAGTGGCATTACGAGTGGTCAAGATATGCTG
AAAGCATGGGCGATGGGTGCGCGTGGTTTCATGACTGGTAAAGCCTTTTTACATGGTCTCGGGGCGTATGGGGAAGCTGG
GGTACATCGTTTACTGGAAATTTTCTATAAAGAAATGGATGTATCTATGGCGTTTACTGGTCATCGTAACTTAAAAGACG
TGACCGAAGCAATTTTGGTGAAAGGCACTTACCCTACCGCAAACTGA

Upstream 100 bases:

>100_bases
TTGTAAAAAATAAGTTGTTGAAATAACATTTTTCTCTATAATCAAATCTTAATGATAATTAATATCATTAAATAAGAATG
GATACTTAGATGAGGATTAT

Downstream 100 bases:

>100_bases
GAAAAAAAGACAACGTTTTTGCACCAAGCGGAGCATAACGCTGTCTTTCTCATGTTTTCACATAGTCGCATTAATGCGAC
TATGTTTTTTTCGGAACGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKDLSKMTCLEDLRRVAQRKVPKMFYDYVVSGSWSESTLHANRNDFQAIKLRQRVLVDMEGRSLESTMIGQQVKMPLAIA
PTGFTGMVHPDGEIHAARAAEKFGIPFSLSTMSICSIEDVAEHTSAPFWFQLYVMRDREFMRNLIKRAQAAKCSALILTA
DLQVLGQRHRDIKNGLSAPPKPTLRNWINLATKLEWSLKMLGTQRRTFRNIVGHAKNVGDLSSLTSWTSEQFDPRLSWDD
VAEIKALWGGKLIIKGIMEPEDAEMAVKSGADAIVVSNHGGRQLDGALSSIQALPNIVSAVGNEIEVWLDSGITSGQDML
KAWAMGARGFMTGKAFLHGLGAYGEAGVHRLLEIFYKEMDVSMAFTGHRNLKDVTEAILVKGTYPTAN

Sequences:

>Translated_388_residues
MKDLSKMTCLEDLRRVAQRKVPKMFYDYVVSGSWSESTLHANRNDFQAIKLRQRVLVDMEGRSLESTMIGQQVKMPLAIA
PTGFTGMVHPDGEIHAARAAEKFGIPFSLSTMSICSIEDVAEHTSAPFWFQLYVMRDREFMRNLIKRAQAAKCSALILTA
DLQVLGQRHRDIKNGLSAPPKPTLRNWINLATKLEWSLKMLGTQRRTFRNIVGHAKNVGDLSSLTSWTSEQFDPRLSWDD
VAEIKALWGGKLIIKGIMEPEDAEMAVKSGADAIVVSNHGGRQLDGALSSIQALPNIVSAVGNEIEVWLDSGITSGQDML
KAWAMGARGFMTGKAFLHGLGAYGEAGVHRLLEIFYKEMDVSMAFTGHRNLKDVTEAILVKGTYPTAN
>Mature_388_residues
MKDLSKMTCLEDLRRVAQRKVPKMFYDYVVSGSWSESTLHANRNDFQAIKLRQRVLVDMEGRSLESTMIGQQVKMPLAIA
PTGFTGMVHPDGEIHAARAAEKFGIPFSLSTMSICSIEDVAEHTSAPFWFQLYVMRDREFMRNLIKRAQAAKCSALILTA
DLQVLGQRHRDIKNGLSAPPKPTLRNWINLATKLEWSLKMLGTQRRTFRNIVGHAKNVGDLSSLTSWTSEQFDPRLSWDD
VAEIKALWGGKLIIKGIMEPEDAEMAVKSGADAIVVSNHGGRQLDGALSSIQALPNIVSAVGNEIEVWLDSGITSGQDML
KAWAMGARGFMTGKAFLHGLGAYGEAGVHRLLEIFYKEMDVSMAFTGHRNLKDVTEAILVKGTYPTAN

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=379, Percent_Identity=35.3562005277045, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI54234014, Length=376, Percent_Identity=35.9042553191489, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI7705393, Length=376, Percent_Identity=35.9042553191489, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=43.7665782493369, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI193208036, Length=377, Percent_Identity=34.7480106100796, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32566217, Length=294, Percent_Identity=32.9931972789116, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=394, Percent_Identity=28.6802030456853, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI78707188, Length=375, Percent_Identity=37.6, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI281363140, Length=375, Percent_Identity=37.6, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI78707190, Length=375, Percent_Identity=37.6, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 43012; Mature: 43012

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLSKMTCLEDLRRVAQRKVPKMFYDYVVSGSWSESTLHANRNDFQAIKLRQRVLVDME
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEECC
GRSLESTMIGQQVKMPLAIAPTGFTGMVHPDGEIHAARAAEKFGIPFSLSTMSICSIEDV
CCCHHHHHHHHHHCCCEEECCCCCCEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHH
AEHTSAPFWFQLYVMRDREFMRNLIKRAQAAKCSALILTADLQVLGQRHRDIKNGLSAPP
HHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCC
KPTLRNWINLATKLEWSLKMLGTQRRTFRNIVGHAKNVGDLSSLTSWTSEQFDPRLSWDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
VAEIKALWGGKLIIKGIMEPEDAEMAVKSGADAIVVSNHGGRQLDGALSSIQALPNIVSA
HHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGNEIEVWLDSGITSGQDMLKAWAMGARGFMTGKAFLHGLGAYGEAGVHRLLEIFYKEMD
CCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VSMAFTGHRNLKDVTEAILVKGTYPTAN
CEEEECCCCCHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MKDLSKMTCLEDLRRVAQRKVPKMFYDYVVSGSWSESTLHANRNDFQAIKLRQRVLVDME
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEECC
GRSLESTMIGQQVKMPLAIAPTGFTGMVHPDGEIHAARAAEKFGIPFSLSTMSICSIEDV
CCCHHHHHHHHHHCCCEEECCCCCCEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHH
AEHTSAPFWFQLYVMRDREFMRNLIKRAQAAKCSALILTADLQVLGQRHRDIKNGLSAPP
HHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCC
KPTLRNWINLATKLEWSLKMLGTQRRTFRNIVGHAKNVGDLSSLTSWTSEQFDPRLSWDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
VAEIKALWGGKLIIKGIMEPEDAEMAVKSGADAIVVSNHGGRQLDGALSSIQALPNIVSA
HHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGNEIEVWLDSGITSGQDMLKAWAMGARGFMTGKAFLHGLGAYGEAGVHRLLEIFYKEMD
CCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VSMAFTGHRNLKDVTEAILVKGTYPTAN
CEEEECCCCCHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA