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The map label for this gene is galE

Identifier: 15602151

GI number: 15602151

Start: 325793

End: 326809

Strand: Reverse

Name: galE

Synonym: PM0286

Alternate gene names: 15602151

Gene position: 326809-325793 (Counterclockwise)

Preceding gene: 15602153

Following gene: 15602150

Centisome position: 14.48

GC content: 40.31

Gene sequence:

>1017_bases
ATGGCGATTCTCGTAACTGGTGGTGCAGGCTATATTGGCTCGCACACCGTCGTTGAACTACTTAATGCAAATAAAGATGT
TGTTGTTTTAGATAATCTTTGTAATTCCTCTCCGAAATCCCTCGAGCGTGTTGCTCAAATCACCGGCAAACAAGTCAAAT
TCTATCAAGGTGATATTTTAGATACCGCACTTTTACAAAAAATCTTCGCTGAAAATCAAATTCAATCTGTGATACATTTT
GCTGGCTTAAAAGCGGTTGGCGAAAGTGTGCAAAAACCCGCTGAATACTATATGAATAACGTCACAGGCTCATTGGTCTT
AATACAAGAAATGAAAAAAGCAGGCGTTTGGAATTTTGTGTTTAGCTCTTCTGCGACGGTGTACGGTGATCCTGAAATTA
TTCCGATCACTGAAAGTTGTAAAGTAGGCGGAACAACAAATCCTTATGGCACCTCAAAATTTATGGTGGAGCAAATTTTA
AAAGATATCGCCAAAGCGACACCGGAATTTAGCATTACGATCTTGCGTTATTTTAACCCTGTTGGTGCACATGAAAGTGG
CTTAATTGGGGAAGATCCAAATGGCATTCCAAATAATTTATTGCCTTATATTAGCCAAGTGGCAATCGGTAAGTTGCCAC
AACTTTCGGTATTTGGTAGTGATTATGAGACTCACGATGGTACTGGGGTACGTGATTATATTCATGTGGTCGATCTTGCT
ATTGGTCACCTTAAAGCACTTGACCGTCACGAAGGCGATGCTGGCTTGCATATTTATAATTTAGGGACTGGTAGCGGTTA
TTCTGTATTAGATATGGTCAAGGCGTTTGAGAAAGTAAACGACATCAAAATCCCTTATAAACTTGTTGATCGCCGTCCAG
GTGATATTGCTACCTGTTATTCAGATCCTAGCCTTGCCAAAACAGAACTAAACTGGACAGCAGCGCGTGGTCTTGAACAA
ATGATGAAAGACACTTGGCACTGGCAAAAAAAGAATCCTAAAGGCTATCGAGATTAA

Upstream 100 bases:

>100_bases
ATAAGCCCTGCCTTCTATGTGGGGATAGTGCTTTCCCTTAATTAGCAAAAGATCTATACTACTGACTCTTTGTATCAAAT
AACGCAACTAAGGACATAAT

Downstream 100 bases:

>100_bases
TTATGGAAACCCAAAAACCGAGTTTATTATCCCAAATTTTCAGTCGGAACATGTTGCTGTGTATTTTTACCGGTTTCAGT
TCTGGTTTACCGCTGTATGT

Product: hypothetical protein

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MAILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDILDTALLQKIFAENQIQSVIHF
AGLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFVFSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQIL
KDIAKATPEFSITILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLA
IGHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCYSDPSLAKTELNWTAARGLEQ
MMKDTWHWQKKNPKGYRD

Sequences:

>Translated_338_residues
MAILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDILDTALLQKIFAENQIQSVIHF
AGLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFVFSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQIL
KDIAKATPEFSITILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLA
IGHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCYSDPSLAKTELNWTAARGLEQ
MMKDTWHWQKKNPKGYRD
>Mature_337_residues
AILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDILDTALLQKIFAENQIQSVIHFA
GLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFVFSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQILK
DIAKATPEFSITILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLAI
GHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCYSDPSLAKTELNWTAARGLEQM
MKDTWHWQKKNPKGYRD

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=59.4117647058824, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=59.4117647058824, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=59.4117647058824, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI7657641, Length=347, Percent_Identity=27.6657060518732, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=57.396449704142, Blast_Score=403, Evalue=1e-114,
Organism=Escherichia coli, GI1788353, Length=365, Percent_Identity=26.5753424657534, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994969, Length=363, Percent_Identity=27.8236914600551, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=59.4202898550725, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=59.0778097982709, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17568069, Length=302, Percent_Identity=26.4900662251656, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115532424, Length=339, Percent_Identity=25.0737463126844, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=51.453488372093, Blast_Score=350, Evalue=1e-97,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=58.4795321637427, Blast_Score=428, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_PASMU (Q9CNY5)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245223.1
- ProteinModelPortal:   Q9CNY5
- SMR:   Q9CNY5
- GeneID:   1243633
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0286
- NMPDR:   fig|272843.1.peg.286
- HOGENOM:   HBG755066
- OMA:   VGESTTI
- ProtClustDB:   CLSK870036
- BioCyc:   PMUL272843:PM0286-MONOMER
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF39
- TIGRFAMs:   TIGR01179

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 37069; Mature: 36938

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 149-149 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDIL
CEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCHH
DTALLQKIFAENQIQSVIHFAGLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEE
FSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQILKDIAKATPEFSITILRYFNP
ECCCCEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
IGHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCY
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEC
SDPSLAKTELNWTAARGLEQMMKDTWHWQKKNPKGYRD
CCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDIL
EEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCHH
DTALLQKIFAENQIQSVIHFAGLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEE
FSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQILKDIAKATPEFSITILRYFNP
ECCCCEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
IGHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCY
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEC
SDPSLAKTELNWTAARGLEQMMKDTWHWQKKNPKGYRD
CCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100