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The map label for this gene is lepB [H]

Identifier: 15601927

GI number: 15601927

Start: 88301

End: 89323

Strand: Reverse

Name: lepB [H]

Synonym: PM0062

Alternate gene names: 15601927

Gene position: 89323-88301 (Counterclockwise)

Preceding gene: 15601928

Following gene: 15601926

Centisome position: 3.96

GC content: 40.96

Gene sequence:

>1023_bases
ATGTCTAACTTCTTCCTCATTCTATTGTTAGTAGCAGGATTCGGTGTCTGGAAAGTATTAGATTATTTTGCCTTACCTAA
CACGTTTTCCATCTTGCTTATTCTCTTGACCGTCATTTCTGGCGCCTTGTGGTGCTATTACCGTTTTACGGTCCAACCAC
GGCGCGCAAGACAAATTGCGCGTGCAGAACAACGTTCTGGCAAAGCACTCAGCGATGAAGAAAAGGCTAAAATTGAACCC
ATCTCAGAAGGCGGAGAGTTTTTATCTTCACTGTTTCCGGTTCTCGCCTTTGTGTTAATTTTACGTTCCTTTTTGTTTGA
ACCCTTTCAAATTCCATCTTCATCAATGGAACCAACATTGCGTATTGGTGACTTTTTGGTAGTAAAAAAATACGCATACG
GGATTAAAGATCCTGTGTTCCAAAACACGATAATTGAAACTGGCAAACCTGAACGTGGCGATATTATTGTGTTTAAAGCC
CCGTTACAACCTAGCGTAGATTATATTAAACGTGTTGTCGGCGCACCGGGCGATAAAGTGCAATACAACGAATACACGCG
TCAATTAACTTTAACCTATGCGAAAGACGGTCAAGAATGTCACAGTGACTGTGAAACAAAAATCTTTAGCTATACTGAGC
CTAAAGAAAATCCCGACTTTCAGTTTCTGATTGGACGTGATCATAAAGGTGAATATCTATATGGTCCTTCGCCGTTAGAA
ACCACCGAAACAGGCGATGTGTCTCACCAAATTCACTGGTATCCTGAACCAATTTCAGAAGGTTTTCGTTATAAAGCCTA
CCGTTCACAAAGCAATTATGTGACAGAATGGGTCGTACCAGAAGGGCATTATTTTGTGATGGGCGACAATCGTAATAACA
GTGAAGACAGCCGTTTTTGGGGCTTTGTCCCAGAGAAAAACATTGTGGGGAAAGCCACATATATTTGGTTGAGTTTAGAT
AAAAAACAAGATCAATGGCCAACAGGCGTCCGTTTTGAACGCTTTTTTACAGAAATTAAGTAA

Upstream 100 bases:

>100_bases
AAAACGCATGAAGTCTTTGGGTAACGTCGAAGTACCACAAGAAGCCTTCTTAGCGATTTTACATGTCGGAAAAGACAAAT
AAGGAACATCAGGAAATACT

Downstream 100 bases:

>100_bases
TAAGTAATGACTCAAAATTTAGAACGTTTACAACGCCAGATTGGTTATCAATTTAACCAACCGGCGTTGCTTAAACAAGC
ATTAACACACCGCAGTGCCG

Product: hypothetical protein

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSNFFLILLLVAGFGVWKVLDYFALPNTFSILLILLTVISGALWCYYRFTVQPRRARQIARAEQRSGKALSDEEKAKIEP
ISEGGEFLSSLFPVLAFVLILRSFLFEPFQIPSSSMEPTLRIGDFLVVKKYAYGIKDPVFQNTIIETGKPERGDIIVFKA
PLQPSVDYIKRVVGAPGDKVQYNEYTRQLTLTYAKDGQECHSDCETKIFSYTEPKENPDFQFLIGRDHKGEYLYGPSPLE
TTETGDVSHQIHWYPEPISEGFRYKAYRSQSNYVTEWVVPEGHYFVMGDNRNNSEDSRFWGFVPEKNIVGKATYIWLSLD
KKQDQWPTGVRFERFFTEIK

Sequences:

>Translated_340_residues
MSNFFLILLLVAGFGVWKVLDYFALPNTFSILLILLTVISGALWCYYRFTVQPRRARQIARAEQRSGKALSDEEKAKIEP
ISEGGEFLSSLFPVLAFVLILRSFLFEPFQIPSSSMEPTLRIGDFLVVKKYAYGIKDPVFQNTIIETGKPERGDIIVFKA
PLQPSVDYIKRVVGAPGDKVQYNEYTRQLTLTYAKDGQECHSDCETKIFSYTEPKENPDFQFLIGRDHKGEYLYGPSPLE
TTETGDVSHQIHWYPEPISEGFRYKAYRSQSNYVTEWVVPEGHYFVMGDNRNNSEDSRFWGFVPEKNIVGKATYIWLSLD
KKQDQWPTGVRFERFFTEIK
>Mature_339_residues
SNFFLILLLVAGFGVWKVLDYFALPNTFSILLILLTVISGALWCYYRFTVQPRRARQIARAEQRSGKALSDEEKAKIEPI
SEGGEFLSSLFPVLAFVLILRSFLFEPFQIPSSSMEPTLRIGDFLVVKKYAYGIKDPVFQNTIIETGKPERGDIIVFKAP
LQPSVDYIKRVVGAPGDKVQYNEYTRQLTLTYAKDGQECHSDCETKIFSYTEPKENPDFQFLIGRDHKGEYLYGPSPLET
TETGDVSHQIHWYPEPISEGFRYKAYRSQSNYVTEWVVPEGHYFVMGDNRNNSEDSRFWGFVPEKNIVGKATYIWLSLDK
KQDQWPTGVRFERFFTEIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=326, Percent_Identity=44.7852760736196, Blast_Score=278, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 39255; Mature: 39124

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFFLILLLVAGFGVWKVLDYFALPNTFSILLILLTVISGALWCYYRFTVQPRRARQIA
CCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHH
RAEQRSGKALSDEEKAKIEPISEGGEFLSSLFPVLAFVLILRSFLFEPFQIPSSSMEPTL
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
RIGDFLVVKKYAYGIKDPVFQNTIIETGKPERGDIIVFKAPLQPSVDYIKRVVGAPGDKV
ECCCEEEEHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCE
QYNEYTRQLTLTYAKDGQECHSDCETKIFSYTEPKENPDFQFLIGRDHKGEYLYGPSPLE
ECCCCEEEEEEEECCCCHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCEEECCCCCC
TTETGDVSHQIHWYPEPISEGFRYKAYRSQSNYVTEWVVPEGHYFVMGDNRNNSEDSRFW
CCCCCCCCCEEEECCCHHHCCCEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCEEE
GFVPEKNIVGKATYIWLSLDKKQDQWPTGVRFERFFTEIK
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SNFFLILLLVAGFGVWKVLDYFALPNTFSILLILLTVISGALWCYYRFTVQPRRARQIA
CCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHH
RAEQRSGKALSDEEKAKIEPISEGGEFLSSLFPVLAFVLILRSFLFEPFQIPSSSMEPTL
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
RIGDFLVVKKYAYGIKDPVFQNTIIETGKPERGDIIVFKAPLQPSVDYIKRVVGAPGDKV
ECCCEEEEHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCE
QYNEYTRQLTLTYAKDGQECHSDCETKIFSYTEPKENPDFQFLIGRDHKGEYLYGPSPLE
ECCCCEEEEEEEECCCCHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCEEECCCCCC
TTETGDVSHQIHWYPEPISEGFRYKAYRSQSNYVTEWVVPEGHYFVMGDNRNNSEDSRFW
CCCCCCCCCEEEECCCHHHCCCEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCEEE
GFVPEKNIVGKATYIWLSLDKKQDQWPTGVRFERFFTEIK
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]