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The map label for this gene is rnc

Identifier: 15601926

GI number: 15601926

Start: 87617

End: 88294

Strand: Reverse

Name: rnc

Synonym: PM0061

Alternate gene names: 15601926

Gene position: 88294-87617 (Counterclockwise)

Preceding gene: 15601927

Following gene: 15601925

Centisome position: 3.91

GC content: 44.1

Gene sequence:

>678_bases
ATGACTCAAAATTTAGAACGTTTACAACGCCAGATTGGTTATCAATTTAACCAACCGGCGTTGCTTAAACAAGCATTAAC
ACACCGCAGTGCCGCGGTTAAGCACAACGAGCGTCTTGAGTTTCTCGGCGATGCCATTTTAAATTTCATCATTGCTGAAG
CACTCTATCACCAGTTTCCCAAATGTAATGAAGGGGAATTAAGTCGTATGCGAGCCACGCTAGTACGTGAGCCGACGCTC
GCGTCATTAGCTCGCCAATTTGAATTGGGGGATTATTTATCGCTCGGACCGGGCGAATTAAAAAGCGGCGGTTTTCGTCG
CGAGTCGATTCTAGCTGACTGTGTGGAAGCCATTATTGGCGCTATCTCTTTAGATAGTGACTTAGCCACTACCACGAAAA
TCGTACAACATTGGTACCAAGCACAGCTCAAACAAATCCAACCGGGTGACAATCAAAAAGACCCCAAAACACGCTTACAG
GAATATTTACAGGGTAAACGTCTTCCTCTCCCAACTTACAATGTGGTTGAAATCAAAGGTGAAGCCCATTGCCAAACGTT
TACTGTCGAATGTTACGTGAAAAATATTGACCGCACTTTTATGGGAAGCGGTGCAAGTCGCCGTAAAGCTGAACAAGCGG
CAGCAGAAAAAATTTTACAATTATTGGAAATGAAATGA

Upstream 100 bases:

>100_bases
GAAAGCCACATATATTTGGTTGAGTTTAGATAAAAAACAAGATCAATGGCCAACAGGCGTCCGTTTTGAACGCTTTTTTA
CAGAAATTAAGTAATAAGTA

Downstream 100 bases:

>100_bases
ACGAAATAAAGACGGCAGATAACGCCAAAACTTACTGTGGCTTTATTGCTATTGTAGGTCGTCCTAATGTAGGGAAATCC
ACCCTTTTGAATAAAATCTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTQNLERLQRQIGYQFNQPALLKQALTHRSAAVKHNERLEFLGDAILNFIIAEALYHQFPKCNEGELSRMRATLVREPTL
ASLARQFELGDYLSLGPGELKSGGFRRESILADCVEAIIGAISLDSDLATTTKIVQHWYQAQLKQIQPGDNQKDPKTRLQ
EYLQGKRLPLPTYNVVEIKGEAHCQTFTVECYVKNIDRTFMGSGASRRKAEQAAAEKILQLLEMK

Sequences:

>Translated_225_residues
MTQNLERLQRQIGYQFNQPALLKQALTHRSAAVKHNERLEFLGDAILNFIIAEALYHQFPKCNEGELSRMRATLVREPTL
ASLARQFELGDYLSLGPGELKSGGFRRESILADCVEAIIGAISLDSDLATTTKIVQHWYQAQLKQIQPGDNQKDPKTRLQ
EYLQGKRLPLPTYNVVEIKGEAHCQTFTVECYVKNIDRTFMGSGASRRKAEQAAAEKILQLLEMK
>Mature_224_residues
TQNLERLQRQIGYQFNQPALLKQALTHRSAAVKHNERLEFLGDAILNFIIAEALYHQFPKCNEGELSRMRATLVREPTLA
SLARQFELGDYLSLGPGELKSGGFRRESILADCVEAIIGAISLDSDLATTTKIVQHWYQAQLKQIQPGDNQKDPKTRLQE
YLQGKRLPLPTYNVVEIKGEAHCQTFTVECYVKNIDRTFMGSGASRRKAEQAAAEKILQLLEMK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=31.140350877193, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=31.140350877193, Blast_Score=107, Evalue=8e-24,
Organism=Escherichia coli, GI1788920, Length=221, Percent_Identity=66.0633484162896, Blast_Score=299, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137682, Length=231, Percent_Identity=30.7359307359307, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_PASMU (P57805)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244998.1
- ProteinModelPortal:   P57805
- SMR:   P57805
- GeneID:   1243408
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0061
- NMPDR:   fig|272843.1.peg.61
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   PMUL272843:PM0061-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25462; Mature: 25330

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNLERLQRQIGYQFNQPALLKQALTHRSAAVKHNERLEFLGDAILNFIIAEALYHQFP
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KCNEGELSRMRATLVREPTLASLARQFELGDYLSLGPGELKSGGFRRESILADCVEAIIG
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AISLDSDLATTTKIVQHWYQAQLKQIQPGDNQKDPKTRLQEYLQGKRLPLPTYNVVEIKG
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECC
EAHCQTFTVECYVKNIDRTFMGSGASRRKAEQAAAEKILQLLEMK
CCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQNLERLQRQIGYQFNQPALLKQALTHRSAAVKHNERLEFLGDAILNFIIAEALYHQFP
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KCNEGELSRMRATLVREPTLASLARQFELGDYLSLGPGELKSGGFRRESILADCVEAIIG
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AISLDSDLATTTKIVQHWYQAQLKQIQPGDNQKDPKTRLQEYLQGKRLPLPTYNVVEIKG
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECC
EAHCQTFTVECYVKNIDRTFMGSGASRRKAEQAAAEKILQLLEMK
CCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100