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The map label for this gene is era

Identifier: 15601925

GI number: 15601925

Start: 86700

End: 87620

Strand: Reverse

Name: era

Synonym: PM0060

Alternate gene names: 15601925

Gene position: 87620-86700 (Counterclockwise)

Preceding gene: 15601926

Following gene: 15601917

Centisome position: 3.88

GC content: 40.93

Gene sequence:

>921_bases
ATGAACGAAATAAAGACGGCAGATAACGCCAAAACTTACTGTGGCTTTATTGCTATTGTAGGTCGTCCTAATGTAGGGAA
ATCCACCCTTTTGAATAAAATCTTGGGGCAAAAAATTTCAATTACCTCACGCAAAGCGCAGACAACCCGTCATCGCATTG
TAGGTATTCACACTGACGGTCCTTATCAAGCAGTGTATGTTGATACACCGGGCTTACATATTGAAGAAAAACGCGCGATT
AATCGTTTAATGAACCGTGCAGCAAGCAGTGCAATTGGTGATGTGGATCTGATTATCTTTGTGGTAGATGGTACGCATTG
GAATGAAGATGATGAAATGGTGCTCAATAAATTGCGTGCGGCGAAAGCCCCCGTGGTGCTCGCAATTAATAAAATTGACA
ACATCAAAAACAAAGAAGAGATGCTACCATTTATTACCGAGCTGACCAGTAAATTTGACTTTGCCCACGTAGTCCCAATT
TCGGCACAAGGGGGCAAAAATATCGCAGAATTAGAAAAAATTGTGCGTGAATCTTTACATGAAGGTACGCATCATTTCCC
TGAAGAATACGTGACTGATCGTTCACAACGCTTTATGGCCTCCGAAATCATCCGTGAAAAACTCATGCGTTTTACCGGTG
ATGAATTACCTTATTCTGTTACCGTAGAAATTGAACAATTTAAATTGAACGAACGCGGCACTTACGAAATCAATGGATTA
ATTCTAGTTGAACGTGAAGGTCAGAAAAAAATGGTGATCGGCAATAAAGGGCAAAAAATCAAACAAATTGGTATTGAAGC
GCGTGCTGATATGGAACGCTTGTTTGATAATAAAGTCCACCTTGAGCTGTGGGTGAAAGTCAAATCAGGTTGGGCGGATG
ATGAACGCGCCTTACGTAGTTTAGGTTATATGGACGAATAA

Upstream 100 bases:

>100_bases
ACGTGAAAAATATTGACCGCACTTTTATGGGAAGCGGTGCAAGTCGCCGTAAAGCTGAACAAGCGGCAGCAGAAAAAATT
TTACAATTATTGGAAATGAA

Downstream 100 bases:

>100_bases
CTAAATTTCCGACCTTGTGTAAAAGAGTGGTAAAGCCACTCTTTTTTATTGTTTCTACACGATAAAAAAACCGCGAATGC
CTTTGCACTCGCGGTATATA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNEIKTADNAKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTDGPYQAVYVDTPGLHIEEKRAI
NRLMNRAASSAIGDVDLIIFVVDGTHWNEDDEMVLNKLRAAKAPVVLAINKIDNIKNKEEMLPFITELTSKFDFAHVVPI
SAQGGKNIAELEKIVRESLHEGTHHFPEEYVTDRSQRFMASEIIREKLMRFTGDELPYSVTVEIEQFKLNERGTYEINGL
ILVEREGQKKMVIGNKGQKIKQIGIEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE

Sequences:

>Translated_306_residues
MNEIKTADNAKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTDGPYQAVYVDTPGLHIEEKRAI
NRLMNRAASSAIGDVDLIIFVVDGTHWNEDDEMVLNKLRAAKAPVVLAINKIDNIKNKEEMLPFITELTSKFDFAHVVPI
SAQGGKNIAELEKIVRESLHEGTHHFPEEYVTDRSQRFMASEIIREKLMRFTGDELPYSVTVEIEQFKLNERGTYEINGL
ILVEREGQKKMVIGNKGQKIKQIGIEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE
>Mature_306_residues
MNEIKTADNAKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTDGPYQAVYVDTPGLHIEEKRAI
NRLMNRAASSAIGDVDLIIFVVDGTHWNEDDEMVLNKLRAAKAPVVLAINKIDNIKNKEEMLPFITELTSKFDFAHVVPI
SAQGGKNIAELEKIVRESLHEGTHHFPEEYVTDRSQRFMASEIIREKLMRFTGDELPYSVTVEIEQFKLNERGTYEINGL
ILVEREGQKKMVIGNKGQKIKQIGIEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=320, Percent_Identity=25.3125, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=76.6891891891892, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI87082120, Length=186, Percent_Identity=31.1827956989247, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646434, Length=302, Percent_Identity=27.1523178807947, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_PASMU (Q9CPH8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244997.1
- ProteinModelPortal:   Q9CPH8
- SMR:   Q9CPH8
- GeneID:   1243407
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0060
- NMPDR:   fig|272843.1.peg.60
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   PMUL272843:PM0060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34714; Mature: 34714

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIKTADNAKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTDG
CCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCEEEECCHHHHCCCEEEEEEECCC
PYQAVYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVDGTHWNEDDEMVLNKLRA
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
AKAPVVLAINKIDNIKNKEEMLPFITELTSKFDFAHVVPISAQGGKNIAELEKIVRESLH
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
EGTHHFPEEYVTDRSQRFMASEIIREKLMRFTGDELPYSVTVEIEQFKLNERGTYEINGL
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCEEEEEE
ILVEREGQKKMVIGNKGQKIKQIGIEARADMERLFDNKVHLELWVKVKSGWADDERALRS
EEEEECCCEEEEECCCCCHHHHHCCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHH
LGYMDE
CCCCCC
>Mature Secondary Structure
MNEIKTADNAKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTDG
CCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCEEEECCHHHHCCCEEEEEEECCC
PYQAVYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVDGTHWNEDDEMVLNKLRA
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
AKAPVVLAINKIDNIKNKEEMLPFITELTSKFDFAHVVPISAQGGKNIAELEKIVRESLH
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
EGTHHFPEEYVTDRSQRFMASEIIREKLMRFTGDELPYSVTVEIEQFKLNERGTYEINGL
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCEEEEEE
ILVEREGQKKMVIGNKGQKIKQIGIEARADMERLFDNKVHLELWVKVKSGWADDERALRS
EEEEECCCEEEEECCCCCHHHHHCCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHH
LGYMDE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100