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The map label for this gene is pth [H]

Identifier: 15595132

GI number: 15595132

Start: 823816

End: 824382

Strand: Direct

Name: pth [H]

Synonym: BB0787

Alternate gene names: 15595132

Gene position: 823816-824382 (Clockwise)

Preceding gene: 161511075

Following gene: 15595133

Centisome position: 90.46

GC content: 30.69

Gene sequence:

>567_bases
ATGGGGTTGTTGATACTTGGATTAGGAAACCCTGGATTAGAATTTTCTTTAACTAGGCATAATGTTGGTTTTTCTCTTTT
GGATAAAATTGTTTCTAAAAACGGCCTTTTTTTAAAGAGAAAAAAAAAGTATGAATATTCAGAATTAAAAATGATTTCCG
GAAGAGTAATTTTGGTTAAGCCATTGACCTATATGAATCTAAGTGGCTCTCTATTTCCTTCAATATTTTCAGATTTTTAT
ATGTGTATAAAGAATTTATTAGTGGTTCTTGACAATGTTGATCTTCCCCTGGGAAAATGCAGGCTTAAAGAGCGAGGTGG
TGTGTCTACTCATAATGGTCTTAGATCGATTTCAAGTGTTCTTGGAAGCTCTAACTATAGTAGACTTTATATTGGGGTTG
GAAGCAATCTTATGCGTGATATAAAGAGTTTTGTTCTTTCTAGATTTTGCAAGGATGAAATGGATAGACTTGAAAAATTG
TATGATTTTTTAAGTGATGAGCTGATTGATATTAGCGAAGCAAATTTTAAAAATAAGGTTCAAAAAATTAATTCTAGTAA
TTTTTAA

Upstream 100 bases:

>100_bases
AAAGGAGATAGCGTTCTTCTTAAAGATCTTGTGTTGCCTTCTAATGTTAGGCTTGCAGAAAATGACGAGAATTTGGAAGT
TGTTATTATAAAGTGATTTT

Downstream 100 bases:

>100_bases
TGCATTTTTTAGACGAAAATATACAAATTAAAATAGATAAATTTTATAAAAAAAATTCTTTAGATAAAAATCGGGTTATT
GTTGCTTTTTCTGGCGGGGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MGLLILGLGNPGLEFSLTRHNVGFSLLDKIVSKNGLFLKRKKKYEYSELKMISGRVILVKPLTYMNLSGSLFPSIFSDFY
MCIKNLLVVLDNVDLPLGKCRLKERGGVSTHNGLRSISSVLGSSNYSRLYIGVGSNLMRDIKSFVLSRFCKDEMDRLEKL
YDFLSDELIDISEANFKNKVQKINSSNF

Sequences:

>Translated_188_residues
MGLLILGLGNPGLEFSLTRHNVGFSLLDKIVSKNGLFLKRKKKYEYSELKMISGRVILVKPLTYMNLSGSLFPSIFSDFY
MCIKNLLVVLDNVDLPLGKCRLKERGGVSTHNGLRSISSVLGSSNYSRLYIGVGSNLMRDIKSFVLSRFCKDEMDRLEKL
YDFLSDELIDISEANFKNKVQKINSSNF
>Mature_187_residues
GLLILGLGNPGLEFSLTRHNVGFSLLDKIVSKNGLFLKRKKKYEYSELKMISGRVILVKPLTYMNLSGSLFPSIFSDFYM
CIKNLLVVLDNVDLPLGKCRLKERGGVSTHNGLRSISSVLGSSNYSRLYIGVGSNLMRDIKSFVLSRFCKDEMDRLEKLY
DFLSDELIDISEANFKNKVQKINSSNF

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=172, Percent_Identity=29.6511627906977, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1787455, Length=183, Percent_Identity=35.5191256830601, Blast_Score=79, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21250; Mature: 21119

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLILGLGNPGLEFSLTRHNVGFSLLDKIVSKNGLFLKRKKKYEYSELKMISGRVILVK
CCEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHCCCEEEEE
PLTYMNLSGSLFPSIFSDFYMCIKNLLVVLDNVDLPLGKCRLKERGGVSTHNGLRSISSV
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
LGSSNYSRLYIGVGSNLMRDIKSFVLSRFCKDEMDRLEKLYDFLSDELIDISEANFKNKV
HCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCHHHHHH
QKINSSNF
HHHCCCCC
>Mature Secondary Structure 
GLLILGLGNPGLEFSLTRHNVGFSLLDKIVSKNGLFLKRKKKYEYSELKMISGRVILVK
CEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHCCCEEEEE
PLTYMNLSGSLFPSIFSDFYMCIKNLLVVLDNVDLPLGKCRLKERGGVSTHNGLRSISSV
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
LGSSNYSRLYIGVGSNLMRDIKSFVLSRFCKDEMDRLEKLYDFLSDELIDISEANFKNKV
HCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCHHHHHH
QKINSSNF
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA