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The map label for this gene is maeA1 [H]

Identifier: 154247860

GI number: 154247860

Start: 4359008

End: 4360660

Strand: Direct

Name: maeA1 [H]

Synonym: Xaut_3937

Alternate gene names: 154247860

Gene position: 4359008-4360660 (Clockwise)

Preceding gene: 154247859

Following gene: 154247861

Centisome position: 82.11

GC content: 64.19

Gene sequence:

>1653_bases
ATGGCCACCAATAACCTCGCGAAGATCGAGAAGGCTCCAAAGAGCAACCTGTCCGGACTGAACCTGTTGCATGATCCGGT
CCGCAACAAGGGCACGGCCTACACACGCGACGATCGCCGCCAGCTTGGCCTCGAGGGCCTGCTGCCCCACGCCGTCGAGA
CCCTCGACCGCCAGGTGGAGCGCGTGCTCGACCATCTCGACCATGTGAAGGACGAACTCGACCAGTACAGTTACCTGATG
GACCTGGAGGCCCGCAACGAGACGGTCTTCTACAAGGCCGTCATGTCTGACCCCAAGCGTTTCATCCCGATCCTCTACGA
TCCCACCGTGGCGGATGCCTGCGAAGCCTTCGGAAACCTGTATCGTCGCCCCCGCGGCATGTATATCACCCGACACATGA
AGGGGCGCATGGCCGAAGTGCTGCGCAACTGGCCCCAGAAGGACATCCGCTTCGTGTGCGTCTCCACCGGCGGCCGCATC
CTCGGCCTCGGCGACATCGGCGCCAACGGCATGGGCATCCCGATCGGCAAGCTGCAGCTCTACACCGCCTGCGCCGCCGT
GCCTCCCGACGTGCTGCTGCCGGTCCTGTTCGACATCGGGACCTCCAACGAGCACCTGCGCGCCGACCCCTTCTATCTCG
GCACCCGCGAGGCGCCGGTGTCGGAAGCAGAACTCGACGAGCTGACTGAAGAATTCGTGCAGGCCGTTAACGAAGTCTTC
CCCGGCTGCTGCGTGCACTTCGAGGACTGGAAGGGCACCGACGCCATCCGTATGCTTGATCGCTACAAGGACAAGATCCT
CTGCTACAACGACGACATTCAGGGCACCGCCTCGGTGGCGCTCGCCGGCATTGCGGCGGCCATGAAGCAGACGGGCGGCA
AGCTCAAGGACCAGCGCATCCTGTTCCTGGGTGCCGGTTCCGCAGGTCTCGGCATTTCCAAGCTGATCGCCGCCGAGCTG
CAGACGCTGGGCCTCTCGGCTGAGGAAGCCCGCAAGCGCGTCCGCCTGTTCGACGTGAACGGCCTCATCGAATCCTCGCG
CACGGACCTGACCGAAACCCAGAAGCTGTGGGCGCAGAACGAGAAGCCCACCAACAATTTCCTGGAGGTGATCGAGAGCT
TCAAGCCCACTGTCCTGATCGGCGTCTCCACCAAGCCGCGCGCCTTCACCAAAGAGGTGATCGAGGCCATGAGCCGCCTC
AACGACCGTCCGGTGATCTTCGCCCTGTCCAACCCGACCCACAAGGCCGAGTGCACCGCCGAGCAGGCCTATACCTGGTC
GAAGGGGAAGGCGCTGTTCGCCGCCGGCGTCCAGTTCGATGAAGTGGCTTACGACGGCAAGACCTATCGGCCCGGCCAGG
CCAACAACTTCTACATCTACCCGGCCATCGGCCTTGCCACCTACGCTGCCCGCCCCAAGCTGCTGAACGACGAATGCTTC
ATCGTCGCCGCTCACGCCACGGCGGACCAGGTGGGTCCCTCGCTCCAGGCCAAGGGCATGCTGTTCCCGAGCCAGGAGCA
CATCCTGGAAACCGAGGTCACCACCGCGACCCGCATCGTCGAATACATGTTCGATGCCGGCCTCGCGACCGTCGAGCGCC
CGCGCGAGATCCGCTCCTGGGTCGAGAGCCTGCTCTACGCCCCGGCCTACTGA

Upstream 100 bases:

>100_bases
TATGACTATCCGTCCCTGGCACGGCGCTTGCGAAGTTCTTTGCGTAGGCCAGATGGCGTTTTGCCTTCCGGCTCGACATT
GCAAGCAAGGACAATCTAAA

Downstream 100 bases:

>100_bases
GCCGCGCCCTCTCCTTCGGTCGAGACGGGACGAAAGCTACCCCGCTCAGGGTGTTGAAGCCTGAGCGGGGCGGGCGCTGG
GCTGTCTTGGCCGGAACATC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 1 [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MATNNLAKIEKAPKSNLSGLNLLHDPVRNKGTAYTRDDRRQLGLEGLLPHAVETLDRQVERVLDHLDHVKDELDQYSYLM
DLEARNETVFYKAVMSDPKRFIPILYDPTVADACEAFGNLYRRPRGMYITRHMKGRMAEVLRNWPQKDIRFVCVSTGGRI
LGLGDIGANGMGIPIGKLQLYTACAAVPPDVLLPVLFDIGTSNEHLRADPFYLGTREAPVSEAELDELTEEFVQAVNEVF
PGCCVHFEDWKGTDAIRMLDRYKDKILCYNDDIQGTASVALAGIAAAMKQTGGKLKDQRILFLGAGSAGLGISKLIAAEL
QTLGLSAEEARKRVRLFDVNGLIESSRTDLTETQKLWAQNEKPTNNFLEVIESFKPTVLIGVSTKPRAFTKEVIEAMSRL
NDRPVIFALSNPTHKAECTAEQAYTWSKGKALFAAGVQFDEVAYDGKTYRPGQANNFYIYPAIGLATYAARPKLLNDECF
IVAAHATADQVGPSLQAKGMLFPSQEHILETEVTTATRIVEYMFDAGLATVERPREIRSWVESLLYAPAY

Sequences:

>Translated_550_residues
MATNNLAKIEKAPKSNLSGLNLLHDPVRNKGTAYTRDDRRQLGLEGLLPHAVETLDRQVERVLDHLDHVKDELDQYSYLM
DLEARNETVFYKAVMSDPKRFIPILYDPTVADACEAFGNLYRRPRGMYITRHMKGRMAEVLRNWPQKDIRFVCVSTGGRI
LGLGDIGANGMGIPIGKLQLYTACAAVPPDVLLPVLFDIGTSNEHLRADPFYLGTREAPVSEAELDELTEEFVQAVNEVF
PGCCVHFEDWKGTDAIRMLDRYKDKILCYNDDIQGTASVALAGIAAAMKQTGGKLKDQRILFLGAGSAGLGISKLIAAEL
QTLGLSAEEARKRVRLFDVNGLIESSRTDLTETQKLWAQNEKPTNNFLEVIESFKPTVLIGVSTKPRAFTKEVIEAMSRL
NDRPVIFALSNPTHKAECTAEQAYTWSKGKALFAAGVQFDEVAYDGKTYRPGQANNFYIYPAIGLATYAARPKLLNDECF
IVAAHATADQVGPSLQAKGMLFPSQEHILETEVTTATRIVEYMFDAGLATVERPREIRSWVESLLYAPAY
>Mature_549_residues
ATNNLAKIEKAPKSNLSGLNLLHDPVRNKGTAYTRDDRRQLGLEGLLPHAVETLDRQVERVLDHLDHVKDELDQYSYLMD
LEARNETVFYKAVMSDPKRFIPILYDPTVADACEAFGNLYRRPRGMYITRHMKGRMAEVLRNWPQKDIRFVCVSTGGRIL
GLGDIGANGMGIPIGKLQLYTACAAVPPDVLLPVLFDIGTSNEHLRADPFYLGTREAPVSEAELDELTEEFVQAVNEVFP
GCCVHFEDWKGTDAIRMLDRYKDKILCYNDDIQGTASVALAGIAAAMKQTGGKLKDQRILFLGAGSAGLGISKLIAAELQ
TLGLSAEEARKRVRLFDVNGLIESSRTDLTETQKLWAQNEKPTNNFLEVIESFKPTVLIGVSTKPRAFTKEVIEAMSRLN
DRPVIFALSNPTHKAECTAEQAYTWSKGKALFAAGVQFDEVAYDGKTYRPGQANNFYIYPAIGLATYAARPKLLNDECFI
VAAHATADQVGPSLQAKGMLFPSQEHILETEVTTATRIVEYMFDAGLATVERPREIRSWVESLLYAPAY

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=535, Percent_Identity=42.4299065420561, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI62420882, Length=535, Percent_Identity=41.6822429906542, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI62420880, Length=535, Percent_Identity=41.6822429906542, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI239049447, Length=535, Percent_Identity=41.6822429906542, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI4505145, Length=516, Percent_Identity=41.2790697674419, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI270265879, Length=449, Percent_Identity=43.4298440979955, Blast_Score=378, Evalue=1e-105,
Organism=Escherichia coli, GI87081919, Length=500, Percent_Identity=39.4, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788806, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17537199, Length=538, Percent_Identity=42.0074349442379, Blast_Score=422, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322823, Length=568, Percent_Identity=34.8591549295775, Blast_Score=343, Evalue=5e-95,
Organism=Drosophila melanogaster, GI24646386, Length=536, Percent_Identity=42.3507462686567, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24646388, Length=536, Percent_Identity=42.3507462686567, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21356279, Length=540, Percent_Identity=40.3703703703704, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362672, Length=540, Percent_Identity=40.3703703703704, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362674, Length=540, Percent_Identity=40.3703703703704, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281363505, Length=520, Percent_Identity=37.3076923076923, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI78707236, Length=520, Percent_Identity=37.3076923076923, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363503, Length=518, Percent_Identity=37.0656370656371, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI78707232, Length=500, Percent_Identity=37.6, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI78707242, Length=525, Percent_Identity=37.3333333333333, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI78707238, Length=525, Percent_Identity=37.3333333333333, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI78707240, Length=517, Percent_Identity=37.5241779497099, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19922384, Length=538, Percent_Identity=32.8996282527881, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 61106; Mature: 60974

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNNLAKIEKAPKSNLSGLNLLHDPVRNKGTAYTRDDRRQLGLEGLLPHAVETLDRQVE
CCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHH
RVLDHLDHVKDELDQYSYLMDLEARNETVFYKAVMSDPKRFIPILYDPTVADACEAFGNL
HHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEHHCCCCCEEEEEECCCHHHHHHHHHHH
YRRPRGMYITRHMKGRMAEVLRNWPQKDIRFVCVSTGGRILGLGDIGANGMGIPIGKLQL
HHCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHH
YTACAAVPPDVLLPVLFDIGTSNEHLRADPFYLGTREAPVSEAELDELTEEFVQAVNEVF
HHHHHCCCHHHHHHHHHHCCCCCCCEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
PGCCVHFEDWKGTDAIRMLDRYKDKILCYNDDIQGTASVALAGIAAAMKQTGGKLKDQRI
CCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEE
LFLGAGSAGLGISKLIAAELQTLGLSAEEARKRVRLFDVNGLIESSRTDLTETQKLWAQN
EEEECCCCCCCHHHHHHHHHHHHCCCHHHHHCCEEEEECCCHHHCCCCCHHHHHHHHHCC
EKPTNNFLEVIESFKPTVLIGVSTKPRAFTKEVIEAMSRLNDRPVIFALSNPTHKAECTA
CCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCH
EQAYTWSKGKALFAAGVQFDEVAYDGKTYRPGQANNFYIYPAIGLATYAARPKLLNDECF
HHCEEECCCCEEEEECCCHHHEECCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCCCEE
IVAAHATADQVGPSLQAKGMLFPSQEHILETEVTTATRIVEYMFDAGLATVERPREIRSW
EEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH
VESLLYAPAY
HHHHHCCCCC
>Mature Secondary Structure 
ATNNLAKIEKAPKSNLSGLNLLHDPVRNKGTAYTRDDRRQLGLEGLLPHAVETLDRQVE
CCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHH
RVLDHLDHVKDELDQYSYLMDLEARNETVFYKAVMSDPKRFIPILYDPTVADACEAFGNL
HHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEHHCCCCCEEEEEECCCHHHHHHHHHHH
YRRPRGMYITRHMKGRMAEVLRNWPQKDIRFVCVSTGGRILGLGDIGANGMGIPIGKLQL
HHCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHH
YTACAAVPPDVLLPVLFDIGTSNEHLRADPFYLGTREAPVSEAELDELTEEFVQAVNEVF
HHHHHCCCHHHHHHHHHHCCCCCCCEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
PGCCVHFEDWKGTDAIRMLDRYKDKILCYNDDIQGTASVALAGIAAAMKQTGGKLKDQRI
CCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEE
LFLGAGSAGLGISKLIAAELQTLGLSAEEARKRVRLFDVNGLIESSRTDLTETQKLWAQN
EEEECCCCCCCHHHHHHHHHHHHCCCHHHHHCCEEEEECCCHHHCCCCCHHHHHHHHHCC
EKPTNNFLEVIESFKPTVLIGVSTKPRAFTKEVIEAMSRLNDRPVIFALSNPTHKAECTA
CCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCH
EQAYTWSKGKALFAAGVQFDEVAYDGKTYRPGQANNFYIYPAIGLATYAARPKLLNDECF
HHCEEECCCCEEEEECCCHHHEECCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCCCEE
IVAAHATADQVGPSLQAKGMLFPSQEHILETEVTTATRIVEYMFDAGLATVERPREIRSW
EEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH
VESLLYAPAY
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA