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The map label for this gene is livH [H]

Identifier: 154247823

GI number: 154247823

Start: 4317486

End: 4318403

Strand: Direct

Name: livH [H]

Synonym: Xaut_3900

Alternate gene names: 154247823

Gene position: 4317486-4318403 (Clockwise)

Preceding gene: 154247821

Following gene: 154247824

Centisome position: 81.32

GC content: 64.16

Gene sequence:

>918_bases
ATGGAAGTGTTCCTCCAGCAGCTCATCAACGGATTGACCCTCGGGTCGATCTACGGATTGATCGCCATCGGGTACACGAT
GGTGTTCGGCATCATCGGAATGGTGAACTTCGCCCACGGCGATGTCTTCATGGTGAGTGCCTTCATTGGCCTCATCTGCG
TCCTGCTGCTCACCACCGTGCTGGGGATGAGCTCCATCTTCCTCATCCTCGCCATTACCCTCGTGGTGGCCATGGTGTTC
ACCGGGCTGGTGAGCTGGGCCATCGAGCGGGTGGCGTACCGGCCCCTGCGCGGCTCCTTCCGCCTCGCGCCCATGATCTC
CGCCATCGGCATGTCCATCCTGCTCTCCAACTTCGTGCAGGTGGCCCAGGGCCCGCGCAACAAGCCGCTGCCGCCCATGG
TGCCGGACGTGATCGTGGTGATGGAGCGCAATGGCTACCAGGTCACCCTCGCCTACAAGCAGATCATCATCATGGTGGTC
ACCGCGACGCTGCTCGCCGGCTTCTGGTGGCTGGTGCAGAAGACCTCGCTGGGCCGCGCCCAGCGCGCCTGCGAGCAGGA
CCGCAAAATGGCGGCACTGCTGGGCGTGAACGTGGACCGCACCATCTCGCTCACCTTCGTCATCGGTGCCGCGCTCGCCG
CCGTCGCCGGCGTCATGTACCTCATGTATTACGGCGTGGTGAACTTCGCCGACGGCTTCGTGCCGGGCGTGAAGGCCTTC
ACCGCCGCCGTGCTGGGGGGCATCGGCTCGCTGCCGGGGGCGGTTCTGGGCGGGCTGCTGATCGGCCTCATCGAGACCCT
GTGGTCCGCCTATTTCTCCATTGAATACAAGGATGTGGCAGCGTTCTCCATCCTTGTGGTCACGCTCATCTTCCTGCCCC
AGGGCCTGCTGGGCCGGCCGGAAGTGGAGAAGGTCTGA

Upstream 100 bases:

>100_bases
GAAGGGCAGGGCGGGTTATGAGTGGGAAAAGGAGGCAGCGCACAATCGTCGGGCACGATGATAAAATAAGCGCTCCACCA
ACAGAGGGGTTCAGCGGCGG

Downstream 100 bases:

>100_bases
TGGCGCATCCGCCCGTCGCCGACCTGAAGCCGGAGGTCCTGCCCAAGGGCGATCTTCCGGCCCCCGGCCTGCCAGGCGCT
CCGACCCTTCCACCGCCCAC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MEVFLQQLINGLTLGSIYGLIAIGYTMVFGIIGMVNFAHGDVFMVSAFIGLICVLLLTTVLGMSSIFLILAITLVVAMVF
TGLVSWAIERVAYRPLRGSFRLAPMISAIGMSILLSNFVQVAQGPRNKPLPPMVPDVIVVMERNGYQVTLAYKQIIIMVV
TATLLAGFWWLVQKTSLGRAQRACEQDRKMAALLGVNVDRTISLTFVIGAALAAVAGVMYLMYYGVVNFADGFVPGVKAF
TAAVLGGIGSLPGAVLGGLLIGLIETLWSAYFSIEYKDVAAFSILVVTLIFLPQGLLGRPEVEKV

Sequences:

>Translated_305_residues
MEVFLQQLINGLTLGSIYGLIAIGYTMVFGIIGMVNFAHGDVFMVSAFIGLICVLLLTTVLGMSSIFLILAITLVVAMVF
TGLVSWAIERVAYRPLRGSFRLAPMISAIGMSILLSNFVQVAQGPRNKPLPPMVPDVIVVMERNGYQVTLAYKQIIIMVV
TATLLAGFWWLVQKTSLGRAQRACEQDRKMAALLGVNVDRTISLTFVIGAALAAVAGVMYLMYYGVVNFADGFVPGVKAF
TAAVLGGIGSLPGAVLGGLLIGLIETLWSAYFSIEYKDVAAFSILVVTLIFLPQGLLGRPEVEKV
>Mature_305_residues
MEVFLQQLINGLTLGSIYGLIAIGYTMVFGIIGMVNFAHGDVFMVSAFIGLICVLLLTTVLGMSSIFLILAITLVVAMVF
TGLVSWAIERVAYRPLRGSFRLAPMISAIGMSILLSNFVQVAQGPRNKPLPPMVPDVIVVMERNGYQVTLAYKQIIIMVV
TATLLAGFWWLVQKTSLGRAQRACEQDRKMAALLGVNVDRTISLTFVIGAALAAVAGVMYLMYYGVVNFADGFVPGVKAF
TAAVLGGIGSLPGAVLGGLLIGLIETLWSAYFSIEYKDVAAFSILVVTLIFLPQGLLGRPEVEKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=302, Percent_Identity=51.6556291390728, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32750; Mature: 32750

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVFLQQLINGLTLGSIYGLIAIGYTMVFGIIGMVNFAHGDVFMVSAFIGLICVLLLTTV
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGMSSIFLILAITLVVAMVFTGLVSWAIERVAYRPLRGSFRLAPMISAIGMSILLSNFVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAQGPRNKPLPPMVPDVIVVMERNGYQVTLAYKQIIIMVVTATLLAGFWWLVQKTSLGRA
HHCCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRACEQDRKMAALLGVNVDRTISLTFVIGAALAAVAGVMYLMYYGVVNFADGFVPGVKAF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TAAVLGGIGSLPGAVLGGLLIGLIETLWSAYFSIEYKDVAAFSILVVTLIFLPQGLLGRP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
EVEKV
CCCCC
>Mature Secondary Structure
MEVFLQQLINGLTLGSIYGLIAIGYTMVFGIIGMVNFAHGDVFMVSAFIGLICVLLLTTV
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGMSSIFLILAITLVVAMVFTGLVSWAIERVAYRPLRGSFRLAPMISAIGMSILLSNFVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAQGPRNKPLPPMVPDVIVVMERNGYQVTLAYKQIIIMVVTATLLAGFWWLVQKTSLGRA
HHCCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRACEQDRKMAALLGVNVDRTISLTFVIGAALAAVAGVMYLMYYGVVNFADGFVPGVKAF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TAAVLGGIGSLPGAVLGGLLIGLIETLWSAYFSIEYKDVAAFSILVVTLIFLPQGLLGRP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
EVEKV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]