| Definition | Xanthobacter autotrophicus Py2 chromosome, complete genome. |
|---|---|
| Accession | NC_009720 |
| Length | 5,308,934 |
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The map label for this gene is fixR [H]
Identifier: 154246418
GI number: 154246418
Start: 2769024
End: 2769773
Strand: Reverse
Name: fixR [H]
Synonym: Xaut_2477
Alternate gene names: 154246418
Gene position: 2769773-2769024 (Counterclockwise)
Preceding gene: 154246419
Following gene: 154246416
Centisome position: 52.17
GC content: 68.13
Gene sequence:
>750_bases ATGATCGCCGAACCCGAAGCCCCGCCCCGCATCATGCTCCTCACCGGGGCCTCGCGCGGCATCGGCCATGCCACGGTGAA GCGCTTCTCCGCCGCCGGCTGGCGCGTCATCTCCTGCTCGCGCCATGCGTTTCCGGACAAGTGCCCGTGGGGCGCCGGGC CGGAGGACCACATCCAGGTGGACCTCTCCAGCCCCGCCAGCACCAAGGACGCCATCGCCGAGGTCAAGCGCCGCCTGCCG GACGGCCGGCTCGACGCCCTCGTCAACAATGCCGCCATCTCCCCCAAGGGCGAGGGTGGCTCACGGCTCGGCACCCTGGA CACCAACCTTGAGACCTGGGTGGACGTATTTCAGGTGAATTTCTTCGCCCCCATCATGCTGGCGCGAGGACTTTCGGCGG AGCTGGAGAAGGCGCAGGGCTCGGTGGTGAACGTCACCTCCATCGCCGGCTCGCGGGTGCATCCCTTCGCGGGAGCAGCC TATGCCACCTCCAAGGCGGCGCTGGCCTCGCTGACGCGGGAGATGGCGTCGGACTTCGGGCGGCGCGGCATCCGCGTCAA CTCCATCGCGCCGGGGGAGATCGACACCGCCATTCTCTCGCCGGGCACCGACAAGATCGTCGAGCAGATCCCCATGCAGC GGCTCGGCACCCCCGACGAGGTGGCGAAGATCATCTACGTGCTGTGCACCGATACCTCGTCCTACCTCAACGGGGCGGAG ATCCACATCAACGGCGGCCAGCATGTGTGA
Upstream 100 bases:
>100_bases GGCCCCGCCTTCGCGCCCACTTTCTTGACCTTGCAGCGAGAGGGTGCTGCATGTCGGGCCGACATGCTTCAGCCCTGAAT GCCGGCCCGGGACCCTTGTC
Downstream 100 bases:
>100_bases GGCCGGCGCGGGATCTTGAGGCGCTTCGCTCAGGCGGCGCGCGGGCTTGGGTTCAGAGCCAACGGCGCCACTTGAAGAAG ACGTAGGGAAGGATGCCCGA
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 249; Mature: 249
Protein sequence:
>249_residues MIAEPEAPPRIMLLTGASRGIGHATVKRFSAAGWRVISCSRHAFPDKCPWGAGPEDHIQVDLSSPASTKDAIAEVKRRLP DGRLDALVNNAAISPKGEGGSRLGTLDTNLETWVDVFQVNFFAPIMLARGLSAELEKAQGSVVNVTSIAGSRVHPFAGAA YATSKAALASLTREMASDFGRRGIRVNSIAPGEIDTAILSPGTDKIVEQIPMQRLGTPDEVAKIIYVLCTDTSSYLNGAE IHINGGQHV
Sequences:
>Translated_249_residues MIAEPEAPPRIMLLTGASRGIGHATVKRFSAAGWRVISCSRHAFPDKCPWGAGPEDHIQVDLSSPASTKDAIAEVKRRLP DGRLDALVNNAAISPKGEGGSRLGTLDTNLETWVDVFQVNFFAPIMLARGLSAELEKAQGSVVNVTSIAGSRVHPFAGAA YATSKAALASLTREMASDFGRRGIRVNSIAPGEIDTAILSPGTDKIVEQIPMQRLGTPDEVAKIIYVLCTDTSSYLNGAE IHINGGQHV >Mature_249_residues MIAEPEAPPRIMLLTGASRGIGHATVKRFSAAGWRVISCSRHAFPDKCPWGAGPEDHIQVDLSSPASTKDAIAEVKRRLP DGRLDALVNNAAISPKGEGGSRLGTLDTNLETWVDVFQVNFFAPIMLARGLSAELEKAQGSVVNVTSIAGSRVHPFAGAA YATSKAALASLTREMASDFGRRGIRVNSIAPGEIDTAILSPGTDKIVEQIPMQRLGTPDEVAKIIYVLCTDTSSYLNGAE IHINGGQHV
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=30.5220883534137, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=29.1338582677165, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=26.9709543568465, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=31.3492063492063, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=30.0813008130081, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI59889578, Length=239, Percent_Identity=25.9414225941423, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI20149619, Length=230, Percent_Identity=28.695652173913, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI66933014, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4503301, Length=204, Percent_Identity=28.4313725490196, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI4504503, Length=203, Percent_Identity=29.064039408867, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=24.4274809160305, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI126723750, Length=149, Percent_Identity=33.5570469798658, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=25, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI10190704, Length=258, Percent_Identity=27.1317829457364, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI119392083, Length=254, Percent_Identity=27.9527559055118, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=28.7449392712551, Blast_Score=110, Evalue=6e-26, Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=30.5882352941176, Blast_Score=95, Evalue=6e-21, Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=32.8063241106719, Blast_Score=94, Evalue=7e-21, Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=29.9212598425197, Blast_Score=85, Evalue=5e-18, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=29.8387096774194, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI1788459, Length=196, Percent_Identity=30.1020408163265, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=28.968253968254, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1789378, Length=150, Percent_Identity=35.3333333333333, Blast_Score=74, Evalue=9e-15, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=9e-14, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=25.2, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1789208, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=8e-13, Organism=Escherichia coli, GI1787820, Length=233, Percent_Identity=25.3218884120172, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1787526, Length=242, Percent_Identity=30.1652892561983, Blast_Score=61, Evalue=8e-11, Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=32.9317269076305, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=33.0769230769231, Blast_Score=101, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=32.9545454545455, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=27.8225806451613, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=31.6793893129771, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17562908, Length=260, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=29.5019157088123, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=30.9433962264151, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=30.1158301158301, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=32.9501915708812, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.811320754717, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=30.6818181818182, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=29.8449612403101, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=28.0898876404494, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538480, Length=260, Percent_Identity=28.8461538461538, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=26.9076305220884, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=29.7709923664122, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=29.6153846153846, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=27.3076923076923, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI115534694, Length=259, Percent_Identity=27.4131274131274, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17561272, Length=202, Percent_Identity=27.7227722772277, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=27.8195488721804, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=26.3358778625954, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=27.1317829457364, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=30.6201550387597, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17536025, Length=263, Percent_Identity=25.0950570342205, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17508651, Length=259, Percent_Identity=27.4131274131274, Blast_Score=70, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6322067, Length=194, Percent_Identity=31.9587628865979, Blast_Score=84, Evalue=2e-17, Organism=Saccharomyces cerevisiae, GI6323882, Length=204, Percent_Identity=30.3921568627451, Blast_Score=66, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6322227, Length=205, Percent_Identity=28.2926829268293, Blast_Score=65, Evalue=7e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=194, Percent_Identity=25.7731958762887, Blast_Score=64, Evalue=3e-11, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.5789473684211, Blast_Score=114, Evalue=5e-26, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=33.4661354581673, Blast_Score=111, Evalue=4e-25, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=30.5220883534137, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI24643142, Length=260, Percent_Identity=34.2307692307692, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI21357041, Length=263, Percent_Identity=30.0380228136882, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=29.6875, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI24644337, Length=212, Percent_Identity=33.0188679245283, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=30.46875, Blast_Score=88, Evalue=4e-18, Organism=Drosophila melanogaster, GI17737361, Length=260, Percent_Identity=30.3846153846154, Blast_Score=78, Evalue=6e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 26395; Mature: 26395
Theoretical pI: Translated: 7.13; Mature: 7.13
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIAEPEAPPRIMLLTGASRGIGHATVKRFSAAGWRVISCSRHAFPDKCPWGAGPEDHIQV CCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEE DLSSPASTKDAIAEVKRRLPDGRLDALVNNAAISPKGEGGSRLGTLDTNLETWVDVFQVN EECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH FFAPIMLARGLSAELEKAQGSVVNVTSIAGSRVHPFAGAAYATSKAALASLTREMASDFG HHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH RRGIRVNSIAPGEIDTAILSPGTDKIVEQIPMQRLGTPDEVAKIIYVLCTDTSSYLNGAE HCCEEECCCCCCCCCCEEECCCHHHHHHHCCHHHCCCHHHHHHEEEEEECCCHHHCCCCE IHINGGQHV EEECCCCCC >Mature Secondary Structure MIAEPEAPPRIMLLTGASRGIGHATVKRFSAAGWRVISCSRHAFPDKCPWGAGPEDHIQV CCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEE DLSSPASTKDAIAEVKRRLPDGRLDALVNNAAISPKGEGGSRLGTLDTNLETWVDVFQVN EECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH FFAPIMLARGLSAELEKAQGSVVNVTSIAGSRVHPFAGAAYATSKAALASLTREMASDFG HHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH RRGIRVNSIAPGEIDTAILSPGTDKIVEQIPMQRLGTPDEVAKIIYVLCTDTSSYLNGAE HCCEEECCCCCCCCCCEEECCCHHHHHHHCCHHHCCCHHHHHHEEEEEECCCHHHCCCCE IHINGGQHV EEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3313281; 11157954; 12597275 [H]