Click here to switch to the map view.

The map label for this gene is pdxH

Identifier: 154246419

GI number: 154246419

Start: 2769876

End: 2770517

Strand: Reverse

Name: pdxH

Synonym: Xaut_2478

Alternate gene names: 154246419

Gene position: 2770517-2769876 (Counterclockwise)

Preceding gene: 154246425

Following gene: 154246418

Centisome position: 52.19

GC content: 69.0

Gene sequence:

>642_bases
ATGACTTCAAGCACAGGCATGGAAGCCCACAACCCCTTAACATCCGGTGATTTTACGGAAGTCTCCGAGCCGTTCCGGCT
GTTTGCTGAATGGCTCGCCGAGGCCGGGAAGAGCGAGCCCAACGATCCCAACGCCATGACGCTCGCAACCGTCGATCCCG
ATGGCCTGCCCGACGCCCGCATGGTGCTGCTGAAGGGGCTCGACGCGCGCGGCTTCGTGTTCTTCACCAACACCGAGAGC
GCCAAGGGCCGCGAACTGGCGCAGACGCCGAAGGCTGCGCTGGTTTTCCACTGGAAATCCCTGCGCCGGCAGGTGCGGGT
GCGCGGGCCGGTGGAACAGGTGACGGCGGACGAGGCCGACGCCTATTTCGCCACCCGCCCCCGCCTGTCGCAGATCGGCG
CCTGGGCCTCCAGCCAGTCGCGCCCGCTGGAGGGCCGCTTCGCGCTGGAGGCGGCGGTGGCTTCGGCGACCGCGAAATAC
GCCCTCGGCACCGTGCCGCGCCCGCCCCACTGGACCGGCTTCCGCGTGCTGCCGGTGGCCATCGAATTCTGGCACGACCG
CCCGTTCCGGCTGCACGACCGGGTGGTGTTCCGCCGCGAGGGCGAAGGCGCCGACTGGTCGAGGACGCGGCTGTTTCCCT
GA

Upstream 100 bases:

>100_bases
GCGACACAGAGCTTCGCGCCGGCGGATCACGCTTCTATATAAGGAACGGCAGCCGGCCATGGGGACGGCGCGCGAGAGGC
GAGGCACGAGGGGCTCCCAC

Downstream 100 bases:

>100_bases
GGGGCCCCGCCTTCGCGCCCACTTTCTTGACCTTGCAGCGAGAGGGTGCTGCATGTCGGGCCGACATGCTTCAGCCCTGA
ATGCCGGCCCGGGACCCTTG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTSSTGMEAHNPLTSGDFTEVSEPFRLFAEWLAEAGKSEPNDPNAMTLATVDPDGLPDARMVLLKGLDARGFVFFTNTES
AKGRELAQTPKAALVFHWKSLRRQVRVRGPVEQVTADEADAYFATRPRLSQIGAWASSQSRPLEGRFALEAAVASATAKY
ALGTVPRPPHWTGFRVLPVAIEFWHDRPFRLHDRVVFRREGEGADWSRTRLFP

Sequences:

>Translated_213_residues
MTSSTGMEAHNPLTSGDFTEVSEPFRLFAEWLAEAGKSEPNDPNAMTLATVDPDGLPDARMVLLKGLDARGFVFFTNTES
AKGRELAQTPKAALVFHWKSLRRQVRVRGPVEQVTADEADAYFATRPRLSQIGAWASSQSRPLEGRFALEAAVASATAKY
ALGTVPRPPHWTGFRVLPVAIEFWHDRPFRLHDRVVFRREGEGADWSRTRLFP
>Mature_212_residues
TSSTGMEAHNPLTSGDFTEVSEPFRLFAEWLAEAGKSEPNDPNAMTLATVDPDGLPDARMVLLKGLDARGFVFFTNTESA
KGRELAQTPKAALVFHWKSLRRQVRVRGPVEQVTADEADAYFATRPRLSQIGAWASSQSRPLEGRFALEAAVASATAKYA
LGTVPRPPHWTGFRVLPVAIEFWHDRPFRLHDRVVFRREGEGADWSRTRLFP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=178, Percent_Identity=47.1910112359551, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI1787926, Length=192, Percent_Identity=43.2291666666667, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17553712, Length=213, Percent_Identity=35.2112676056338, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=40.6698564593301, Blast_Score=158, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45551845, Length=187, Percent_Identity=43.3155080213904, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24644901, Length=187, Percent_Identity=43.3155080213904, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24644903, Length=167, Percent_Identity=28.7425149700599, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_XANP2 (A7II77)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417377.1
- ProteinModelPortal:   A7II77
- SMR:   A7II77
- STRING:   A7II77
- GeneID:   5422992
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2478
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- ProtClustDB:   CLSK979777
- BioCyc:   XAUT78245:XAUT_2478-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 23752; Mature: 23621

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 60-60 BINDING 63-63 BINDING 65-65 BINDING 82-82 BINDING 122-122 BINDING 126-126 BINDING 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSTGMEAHNPLTSGDFTEVSEPFRLFAEWLAEAGKSEPNDPNAMTLATVDPDGLPDAR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHH
MVLLKGLDARGFVFFTNTESAKGRELAQTPKAALVFHWKSLRRQVRVRGPVEQVTADEAD
HHHHHCCCCCCEEEEECCCCCCCCHHHHCCCHHEEHHHHHHHHHHHCCCCHHHHHCCCCC
AYFATRPRLSQIGAWASSQSRPLEGRFALEAAVASATAKYALGTVPRPPHWTGFRVLPVA
CEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
IEFWHDRPFRLHDRVVFRREGEGADWSRTRLFP
EEECCCCCCEECCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TSSTGMEAHNPLTSGDFTEVSEPFRLFAEWLAEAGKSEPNDPNAMTLATVDPDGLPDAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHH
MVLLKGLDARGFVFFTNTESAKGRELAQTPKAALVFHWKSLRRQVRVRGPVEQVTADEAD
HHHHHCCCCCCEEEEECCCCCCCCHHHHCCCHHEEHHHHHHHHHHHCCCCHHHHHCCCCC
AYFATRPRLSQIGAWASSQSRPLEGRFALEAAVASATAKYALGTVPRPPHWTGFRVLPVA
CEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
IEFWHDRPFRLHDRVVFRREGEGADWSRTRLFP
EEECCCCCCEECCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA