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The map label for this gene is hyi [H]

Identifier: 154246310

GI number: 154246310

Start: 2643869

End: 2644648

Strand: Direct

Name: hyi [H]

Synonym: Xaut_2368

Alternate gene names: 154246310

Gene position: 2643869-2644648 (Clockwise)

Preceding gene: 154246309

Following gene: 154246311

Centisome position: 49.8

GC content: 62.82

Gene sequence:

>780_bases
ATGCCCAAGTTCTGCGCCAACCTCACCATGCTGTGGAACGAGATCGACTTCCTCGACCGGTTCAAAAAGGCGGCTGAGGC
CGGCTTCACCGGGGTCGAGTATCTCTTCCCCTATCCGTATGAAAAGGATGTGCTGGCGGAGAAGCTGGCCACCTACAAGC
TCACCCAGGTGCTGCACAACCTGCCGGCCGGCGACTGGGCGGCGGGCGAGCGCGGCATCGCCTGCCTGCCGGGCCGCGAA
GGCGAGTTCCAGGACAGCGTCGGCAAGGGCATCGACTATGCGAAGGCTCTCGGCACCAAGGCGCTCAACTGCCTCGTCGG
CCTGACCCCGAAGGATGTTCCGGCCGAGAAGGTCCACGAGACCCTGGTGAAGAACCTGAAGTTCGCTGCCGCCGAGCTGA
AGAAGGCCGGCATCCCCTTCGTGGTGGAGGCCATCAACACTCGCGACATCCCGGGCTTCCACCTGCACAACACCAAGCAG
ACGCTGGCGGTGCTGGACGAAGTGGGCGCGGACGACATCTTCTTCCAGTACGACATCTATCACATGCAGATCATGGAAGG
GGACCTCACCCCCACCATCCGCACCAACATTGCCCGCATCAAGCACATCCAGCTGGCCGACAATCCGGGTCGCGGCGAGC
CGGGCACGGGCGAGATCAACTATCCGTTCCTGTTCAAGGCCATCGACGACACCGGCTATGACGGCTGGATCGGATGCGAA
TACAAGCCCAAGACCACCACCGACGAGGGCATCGGCTGGTTCGCGCCCTACAAGGGCTGA

Upstream 100 bases:

>100_bases
ATGGCGGCATGACAAAAGCGTTTTCAAGCGAAGTGGATACCGGTTCGCGTGAAGAAAACGCGTCAGGATATAGCCCAAGG
CTCAGCCCGCGGAGAGACGC

Downstream 100 bases:

>100_bases
TCCTCGGGCTTCCCATCGCGCACGAACAACACGACTCTTCAGGAGAAACGCACATGAACGTCGGATTCATCGGCCTCGGC
ATCATGGGTTCCCCCATGGC

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPKFCANLTMLWNEIDFLDRFKKAAEAGFTGVEYLFPYPYEKDVLAEKLATYKLTQVLHNLPAGDWAAGERGIACLPGRE
GEFQDSVGKGIDYAKALGTKALNCLVGLTPKDVPAEKVHETLVKNLKFAAAELKKAGIPFVVEAINTRDIPGFHLHNTKQ
TLAVLDEVGADDIFFQYDIYHMQIMEGDLTPTIRTNIARIKHIQLADNPGRGEPGTGEINYPFLFKAIDDTGYDGWIGCE
YKPKTTTDEGIGWFAPYKG

Sequences:

>Translated_259_residues
MPKFCANLTMLWNEIDFLDRFKKAAEAGFTGVEYLFPYPYEKDVLAEKLATYKLTQVLHNLPAGDWAAGERGIACLPGRE
GEFQDSVGKGIDYAKALGTKALNCLVGLTPKDVPAEKVHETLVKNLKFAAAELKKAGIPFVVEAINTRDIPGFHLHNTKQ
TLAVLDEVGADDIFFQYDIYHMQIMEGDLTPTIRTNIARIKHIQLADNPGRGEPGTGEINYPFLFKAIDDTGYDGWIGCE
YKPKTTTDEGIGWFAPYKG
>Mature_258_residues
PKFCANLTMLWNEIDFLDRFKKAAEAGFTGVEYLFPYPYEKDVLAEKLATYKLTQVLHNLPAGDWAAGERGIACLPGREG
EFQDSVGKGIDYAKALGTKALNCLVGLTPKDVPAEKVHETLVKNLKFAAAELKKAGIPFVVEAINTRDIPGFHLHNTKQT
LAVLDEVGADDIFFQYDIYHMQIMEGDLTPTIRTNIARIKHIQLADNPGRGEPGTGEINYPFLFKAIDDTGYDGWIGCEY
KPKTTTDEGIGWFAPYKG

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=263, Percent_Identity=38.0228136882129, Blast_Score=180, Evalue=9e-46,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=37.2950819672131, Blast_Score=158, Evalue=5e-39,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=58.1395348837209, Blast_Score=323, Evalue=7e-90,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=40.3100775193798, Blast_Score=221, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=35.8333333333333, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=35.0194552529183, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28752; Mature: 28621

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFCANLTMLWNEIDFLDRFKKAAEAGFTGVEYLFPYPYEKDVLAEKLATYKLTQVLHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LPAGDWAAGERGIACLPGREGEFQDSVGKGIDYAKALGTKALNCLVGLTPKDVPAEKVHE
CCCCCCCCCCCCEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TLVKNLKFAAAELKKAGIPFVVEAINTRDIPGFHLHNTKQTLAVLDEVGADDIFFQYDIY
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEEE
HMQIMEGDLTPTIRTNIARIKHIQLADNPGRGEPGTGEINYPFLFKAIDDTGYDGWIGCE
EEEEECCCCCCHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCC
YKPKTTTDEGIGWFAPYKG
CCCCCCCCCCCEECCCCCC
>Mature Secondary Structure 
PKFCANLTMLWNEIDFLDRFKKAAEAGFTGVEYLFPYPYEKDVLAEKLATYKLTQVLHN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LPAGDWAAGERGIACLPGREGEFQDSVGKGIDYAKALGTKALNCLVGLTPKDVPAEKVHE
CCCCCCCCCCCCEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TLVKNLKFAAAELKKAGIPFVVEAINTRDIPGFHLHNTKQTLAVLDEVGADDIFFQYDIY
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEEE
HMQIMEGDLTPTIRTNIARIKHIQLADNPGRGEPGTGEINYPFLFKAIDDTGYDGWIGCE
EEEEECCCCCCHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCC
YKPKTTTDEGIGWFAPYKG
CCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]