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The map label for this gene is glxR [H]

Identifier: 154246311

GI number: 154246311

Start: 2644702

End: 2645580

Strand: Direct

Name: glxR [H]

Synonym: Xaut_2369

Alternate gene names: 154246311

Gene position: 2644702-2645580 (Clockwise)

Preceding gene: 154246310

Following gene: 154246312

Centisome position: 49.82

GC content: 67.46

Gene sequence:

>879_bases
ATGAACGTCGGATTCATCGGCCTCGGCATCATGGGTTCCCCCATGGCGGGACACCTCATCGACGCCGGCCACACCCTGTT
CGTCTATGACGTGTTCCGCATCCCCGCGGAGCTGACCGCGAAGGGCGCCACCGCCTGCGCCTCCTCCGCCGACGTGGCCA
AGGCCGCCGACGTCATCATCACCATGGTGCCGGATACCCCGCACGTGGAAGAGGCGCTGTTCGGCAAGGGCGGCGTCGCC
GAGGGCCTCGCCAAGGGCAAGATCGTGGTGGACATGAGCTCCATCTCGCCGGTGGCCACCAAGGGCTTCGCGGAGAAGAT
CAACGCGCTCGGCTGCGACTATCTCGATGCCCCGGTCTCCGGCGGCGAGGTGGGCGCCAAGGCCGCCTCCCTCACCATCA
TGGTGGGCGGGCCGGAAGGCGCGTTCGAGACGGTGAAGCCCCTGTTCGAGAAGATGGGCAAGAACATCACCCTCGTGGGC
GGCAACGGCGACGGCCAGACCACCAAGGTCGCGAACCAGATCATCGTGGCCCTTACCATCGAGGCGGTGGGCGAGGCCCT
GCTGTTCGCCTCCAAGGCGGGCGCCGACCCGGCCAAGGTGCGCCAGGCGCTGATGGGCGGCTTCGCCTCCTCCAAGATCC
TCGAAGTGCACGGCGACCGCATGGTGAAGCGTACCTTCGATCCGGGCTTCCGCATCGAGCTGCACCAGAAGGACCTGAAC
CTAGCGCTCCAGAGCGCCAAGGCCCTGGGCGTGAGCCTGCCCAACACCGCCACCTGCCAGGAGCTGTTCAACGCCTGCGC
CGCCCACGGCGGCTCCAAGTGGGACCACTCCGCCATGGTGAAGGCGCTGGAACTGCTGGCGAACCACGAGATCGCCTGA

Upstream 100 bases:

>100_bases
CCACCACCGACGAGGGCATCGGCTGGTTCGCGCCCTACAAGGGCTGATCCTCGGGCTTCCCATCGCGCACGAACAACACG
ACTCTTCAGGAGAAACGCAC

Downstream 100 bases:

>100_bases
ACGCGGGGCGGGTTCAGGCCCGCCTCGACTGGGTTCAAGCCCTCCCCCACGCGGGGGAGGGGCGGGGCCGGCCGCGCCGG
CCTCCTGTCCCTGCCATGGC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNVGFIGLGIMGSPMAGHLIDAGHTLFVYDVFRIPAELTAKGATACASSADVAKAADVIITMVPDTPHVEEALFGKGGVA
EGLAKGKIVVDMSSISPVATKGFAEKINALGCDYLDAPVSGGEVGAKAASLTIMVGGPEGAFETVKPLFEKMGKNITLVG
GNGDGQTTKVANQIIVALTIEAVGEALLFASKAGADPAKVRQALMGGFASSKILEVHGDRMVKRTFDPGFRIELHQKDLN
LALQSAKALGVSLPNTATCQELFNACAAHGGSKWDHSAMVKALELLANHEIA

Sequences:

>Translated_292_residues
MNVGFIGLGIMGSPMAGHLIDAGHTLFVYDVFRIPAELTAKGATACASSADVAKAADVIITMVPDTPHVEEALFGKGGVA
EGLAKGKIVVDMSSISPVATKGFAEKINALGCDYLDAPVSGGEVGAKAASLTIMVGGPEGAFETVKPLFEKMGKNITLVG
GNGDGQTTKVANQIIVALTIEAVGEALLFASKAGADPAKVRQALMGGFASSKILEVHGDRMVKRTFDPGFRIELHQKDLN
LALQSAKALGVSLPNTATCQELFNACAAHGGSKWDHSAMVKALELLANHEIA
>Mature_292_residues
MNVGFIGLGIMGSPMAGHLIDAGHTLFVYDVFRIPAELTAKGATACASSADVAKAADVIITMVPDTPHVEEALFGKGGVA
EGLAKGKIVVDMSSISPVATKGFAEKINALGCDYLDAPVSGGEVGAKAASLTIMVGGPEGAFETVKPLFEKMGKNITLVG
GNGDGQTTKVANQIIVALTIEAVGEALLFASKAGADPAKVRQALMGGFASSKILEVHGDRMVKRTFDPGFRIELHQKDLN
LALQSAKALGVSLPNTATCQELFNACAAHGGSKWDHSAMVKALELLANHEIA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=290, Percent_Identity=34.8275862068965, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=27.7580071174377, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=69.5205479452055, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=44.8979591836735, Blast_Score=240, Evalue=6e-65,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=33.6805555555556, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=30.8771929824561, Blast_Score=104, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=282, Percent_Identity=31.9148936170213, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=36.0824742268041, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=36.0824742268041, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28574115, Length=278, Percent_Identity=29.8561151079137, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24655240, Length=65, Percent_Identity=49.2307692307692, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30068; Mature: 30068

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGFIGLGIMGSPMAGHLIDAGHTLFVYDVFRIPAELTAKGATACASSADVAKAADVII
CCCEEEEECCCCCCCCCCEECCCCEEEEEEHHHCCHHHHCCCHHHHCCCCHHHHHCCEEE
TMVPDTPHVEEALFGKGGVAEGLAKGKIVVDMSSISPVATKGFAEKINALGCDYLDAPVS
EECCCCCCHHHHHHCCCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC
GGEVGAKAASLTIMVGGPEGAFETVKPLFEKMGKNITLVGGNGDGQTTKVANQIIVALTI
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEEEEH
EAVGEALLFASKAGADPAKVRQALMGGFASSKILEVHGDRMVKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCCCCEEEEEHHHHH
LALQSAKALGVSLPNTATCQELFNACAAHGGSKWDHSAMVKALELLANHEIA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVGFIGLGIMGSPMAGHLIDAGHTLFVYDVFRIPAELTAKGATACASSADVAKAADVII
CCCEEEEECCCCCCCCCCEECCCCEEEEEEHHHCCHHHHCCCHHHHCCCCHHHHHCCEEE
TMVPDTPHVEEALFGKGGVAEGLAKGKIVVDMSSISPVATKGFAEKINALGCDYLDAPVS
EECCCCCCHHHHHHCCCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC
GGEVGAKAASLTIMVGGPEGAFETVKPLFEKMGKNITLVGGNGDGQTTKVANQIIVALTI
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEEEEH
EAVGEALLFASKAGADPAKVRQALMGGFASSKILEVHGDRMVKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCCCCEEEEEHHHHH
LALQSAKALGVSLPNTATCQELFNACAAHGGSKWDHSAMVKALELLANHEIA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]