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The map label for this gene is purM [H]

Identifier: 154246265

GI number: 154246265

Start: 2596053

End: 2597126

Strand: Direct

Name: purM [H]

Synonym: Xaut_2323

Alternate gene names: 154246265

Gene position: 2596053-2597126 (Clockwise)

Preceding gene: 154246264

Following gene: 154246266

Centisome position: 48.9

GC content: 69.74

Gene sequence:

>1074_bases
ATGGCTCAGGACGGACTTTCCTACCGCGACGCGGGCGTGGACATCGACGCGGGCAACCGCCTGGTCGATCTCATCAAGCC
GCTGGTGAAGGCCACCGCGCGCCCCGGCGCCGACGCGGACATCGGCGGATTCGGCGGGGTGTTCGACCTGAAGGCGGCCG
GCTTCGCCGACCCTCTCCTCATCGCCACCACGGACGGGGTGGGCACCAAGCTCAAGATCGCCATCGACACCGGCGTGCAC
GACACCATCGGCATCGACCTTGTCGCCATGTGCGTGAACGACCTGGTGGTGCAGGGCGCGGAGCCGCTGCTGTTTCTCGA
CTATTTCGCCACCGGCCGGCTGGCGCCGGAGGTGGGGGCCCATATCGTCGCCGGCATCGCCCGCGCCTGCAAGGAGGCAG
GCTGCGCCCTCATCGGCGGCGAGACCGCCGAGATGCCGGGCATGTACAAGGACGGCGACTACGATCTCGCCGGCTTTTCC
CTCGGCGCGGTGGAACGCGGCGACCTGCTGCCCCGCAAGGATGTGGCGCCGGGCGACGTGATCCTCGGCCTTGCCTCCGC
CGGGGTGCATTCCAACGGCTATTCGCTGGTGCGCCGCGTGGTCGAGCGTTCGGGCCTGGCCTGGTCCGACGCCGCACCGT
TCGAGGCGGGCCAGACGCTGGGCGCGGCCCTTCTCACCCCGACCCGGCTCTATGTGAAGAGCGTGCTGTCGGTGATCCGC
TCCACCGGCTCGGTGAAGGCGCTGGCCCACATCACCGGCGGCGGCATCACCGAGAATTTGCCGCGGGTGCTGCCCAAGGG
CACGCTGGCCCGCATCGACCTCACCAATCTCATGGTGCCGCCGGTGTTCCGCTGGCTCGCCACCGTGGGCGCCGTGGCAC
CGGAGGAGATGCTGCGCGCCTTCAACTGCGGCGTCGGCATGGCCGTGGTGGTGCCGGCCGAGGAGGAGGAGACCGTGGCT
GACGCCTTCGCCGATGCCGGCGAGTGCGTCATCCGCCTCGGCGTCATCGAGCCCGGTGAGGGGCCGGCCCATGTGGCCTA
TGAAGGCACTACTGATTTCGGATTCGCGTCGTGA

Upstream 100 bases:

>100_bases
GAACAGGGCGGATAACCCGGGCGCGCATGGCCCGGTTGCGCGCCCTGCCTTGCTTTGCCCCGCATTCAAAGCTAAGCCCC
GCGCCAGATACGAGGACTTC

Downstream 100 bases:

>100_bases
GCGCTGGGTCGAGTGAGGCGCCGCGCCGCACCGCCGTCCTCATTTCGGGCCGGGGCTCCAATATGGCGGCGCTGGTGCGC
GCGGCCGAACAGGAAGACTT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MAQDGLSYRDAGVDIDAGNRLVDLIKPLVKATARPGADADIGGFGGVFDLKAAGFADPLLIATTDGVGTKLKIAIDTGVH
DTIGIDLVAMCVNDLVVQGAEPLLFLDYFATGRLAPEVGAHIVAGIARACKEAGCALIGGETAEMPGMYKDGDYDLAGFS
LGAVERGDLLPRKDVAPGDVILGLASAGVHSNGYSLVRRVVERSGLAWSDAAPFEAGQTLGAALLTPTRLYVKSVLSVIR
STGSVKALAHITGGGITENLPRVLPKGTLARIDLTNLMVPPVFRWLATVGAVAPEEMLRAFNCGVGMAVVVPAEEEETVA
DAFADAGECVIRLGVIEPGEGPAHVAYEGTTDFGFAS

Sequences:

>Translated_357_residues
MAQDGLSYRDAGVDIDAGNRLVDLIKPLVKATARPGADADIGGFGGVFDLKAAGFADPLLIATTDGVGTKLKIAIDTGVH
DTIGIDLVAMCVNDLVVQGAEPLLFLDYFATGRLAPEVGAHIVAGIARACKEAGCALIGGETAEMPGMYKDGDYDLAGFS
LGAVERGDLLPRKDVAPGDVILGLASAGVHSNGYSLVRRVVERSGLAWSDAAPFEAGQTLGAALLTPTRLYVKSVLSVIR
STGSVKALAHITGGGITENLPRVLPKGTLARIDLTNLMVPPVFRWLATVGAVAPEEMLRAFNCGVGMAVVVPAEEEETVA
DAFADAGECVIRLGVIEPGEGPAHVAYEGTTDFGFAS
>Mature_356_residues
AQDGLSYRDAGVDIDAGNRLVDLIKPLVKATARPGADADIGGFGGVFDLKAAGFADPLLIATTDGVGTKLKIAIDTGVHD
TIGIDLVAMCVNDLVVQGAEPLLFLDYFATGRLAPEVGAHIVAGIARACKEAGCALIGGETAEMPGMYKDGDYDLAGFSL
GAVERGDLLPRKDVAPGDVILGLASAGVHSNGYSLVRRVVERSGLAWSDAAPFEAGQTLGAALLTPTRLYVKSVLSVIRS
TGSVKALAHITGGGITENLPRVLPKGTLARIDLTNLMVPPVFRWLATVGAVAPEEMLRAFNCGVGMAVVVPAEEEETVAD
AFADAGECVIRLGVIEPGEGPAHVAYEGTTDFGFAS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=316, Percent_Identity=59.1772151898734, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=316, Percent_Identity=59.1772151898734, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=316, Percent_Identity=59.1772151898734, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=52.0348837209302, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17567511, Length=341, Percent_Identity=45.7478005865103, Blast_Score=288, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6321203, Length=351, Percent_Identity=52.4216524216524, Blast_Score=371, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24582400, Length=270, Percent_Identity=47.037037037037, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36785; Mature: 36653

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDGLSYRDAGVDIDAGNRLVDLIKPLVKATARPGADADIGGFGGVFDLKAAGFADPLL
CCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEE
IATTDGVGTKLKIAIDTGVHDTIGIDLVAMCVNDLVVQGAEPLLFLDYFATGRLAPEVGA
EEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHH
HIVAGIARACKEAGCALIGGETAEMPGMYKDGDYDLAGFSLGAVERGDLLPRKDVAPGDV
HHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCE
ILGLASAGVHSNGYSLVRRVVERSGLAWSDAAPFEAGQTLGAALLTPTRLYVKSVLSVIR
EEEEHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
STGSVKALAHITGGGITENLPRVLPKGTLARIDLTNLMVPPVFRWLATVGAVAPEEMLRA
CCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHH
FNCGVGMAVVVPAEEEETVADAFADAGECVIRLGVIEPGEGPAHVAYEGTTDFGFAS
HCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
AQDGLSYRDAGVDIDAGNRLVDLIKPLVKATARPGADADIGGFGGVFDLKAAGFADPLL
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEE
IATTDGVGTKLKIAIDTGVHDTIGIDLVAMCVNDLVVQGAEPLLFLDYFATGRLAPEVGA
EEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHH
HIVAGIARACKEAGCALIGGETAEMPGMYKDGDYDLAGFSLGAVERGDLLPRKDVAPGDV
HHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCE
ILGLASAGVHSNGYSLVRRVVERSGLAWSDAAPFEAGQTLGAALLTPTRLYVKSVLSVIR
EEEEHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
STGSVKALAHITGGGITENLPRVLPKGTLARIDLTNLMVPPVFRWLATVGAVAPEEMLRA
CCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHH
FNCGVGMAVVVPAEEEETVADAFADAGECVIRLGVIEPGEGPAHVAYEGTTDFGFAS
HCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA