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The map label for this gene is menB [H]

Identifier: 154244862

GI number: 154244862

Start: 1023670

End: 1024452

Strand: Direct

Name: menB [H]

Synonym: Xaut_0912

Alternate gene names: 154244862

Gene position: 1023670-1024452 (Clockwise)

Preceding gene: 154244861

Following gene: 154244863

Centisome position: 19.28

GC content: 66.03

Gene sequence:

>783_bases
ATGAGCTATACTGACATTCTCTATGAGGTGCGCGGCGGCGCCGCCTGGATCACCATCAACCGGCCGGACAAATACAACGC
CTTCCGCGGCCACACCGTGGACGAGCTGATCCACGCCTTCCAGACCGCAGGCTGGGACCGCAAGGTCGGCGTGATCGTGC
TGACCGGCGCGGGCGACAAGGCATTCTGCACCGGCGGCGACCAGTCGGCCCACGACGGCCAGTATGACGGGCGCGGCGTC
ATCGGCCTGCCCATCGATGAATTGCAGAGCCTGATCCGCGACGTGCCGAAGCCTGTCATCGCCCGCGTCAATGGCTTCGC
CATCGGCGGCGGCAACGTGCTCGCCACCATCTGTGACCTGACCATCGCTTCCGACAAGGCCCAGTTCGGCCAGGTGGGCC
CCAAGGTGGGCTCGGTGGATCCGGGCTTCGGCACCGCCTATCTCGCCCGCGTGGTCGGCGAGAAGAAGGCTCGCGAGATC
TGGTATCTCAACAAACGCTATAGCGCCGCCGAGGCCCTTGCCATGGGCCTTGCCAATGCGGTCGTGCCCCACGAGGAACT
GGACGCCGAGGTGGACCGCTGGGTGGCCGAGCTGATGGACCGCTCGCCCACGGCGCTTGCCCTCGCCAAGGTGTCGTTCA
ACGCCGACAGCGAGAACATCCGGGGCATCTCCGCCCTCGGCATGCGCGCGCTCAGCCTCTACTACGACACCGACGAGAGC
AAGGAGGGCGGTGTCGCCTTCCGCGAGAAGCGCAAGCCCGATTTCCGCAAGTTCGGAAAGTAG

Upstream 100 bases:

>100_bases
GGCGCCATCGTGTTCCTGTCCAGTGACGACGCCGCCTTCATCACCGGCCAGGTGATATCGGTCTCCGGCGGCCTCACCAT
GCACGGTTGAGGGGGAAACC

Downstream 100 bases:

>100_bases
GCCGGACCGCCACCGGGCAGGTGGGCCCGCCGTCCTGTCCGGTGGCTTCAGTCCCCCGAACGGGGGTGTGCCGTGAGGCG
ATCCCGTCCCGCCATGGGCG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSYTDILYEVRGGAAWITINRPDKYNAFRGHTVDELIHAFQTAGWDRKVGVIVLTGAGDKAFCTGGDQSAHDGQYDGRGV
IGLPIDELQSLIRDVPKPVIARVNGFAIGGGNVLATICDLTIASDKAQFGQVGPKVGSVDPGFGTAYLARVVGEKKAREI
WYLNKRYSAAEALAMGLANAVVPHEELDAEVDRWVAELMDRSPTALALAKVSFNADSENIRGISALGMRALSLYYDTDES
KEGGVAFREKRKPDFRKFGK

Sequences:

>Translated_260_residues
MSYTDILYEVRGGAAWITINRPDKYNAFRGHTVDELIHAFQTAGWDRKVGVIVLTGAGDKAFCTGGDQSAHDGQYDGRGV
IGLPIDELQSLIRDVPKPVIARVNGFAIGGGNVLATICDLTIASDKAQFGQVGPKVGSVDPGFGTAYLARVVGEKKAREI
WYLNKRYSAAEALAMGLANAVVPHEELDAEVDRWVAELMDRSPTALALAKVSFNADSENIRGISALGMRALSLYYDTDES
KEGGVAFREKRKPDFRKFGK
>Mature_259_residues
SYTDILYEVRGGAAWITINRPDKYNAFRGHTVDELIHAFQTAGWDRKVGVIVLTGAGDKAFCTGGDQSAHDGQYDGRGVI
GLPIDELQSLIRDVPKPVIARVNGFAIGGGNVLATICDLTIASDKAQFGQVGPKVGSVDPGFGTAYLARVVGEKKAREIW
YLNKRYSAAEALAMGLANAVVPHEELDAEVDRWVAELMDRSPTALALAKVSFNADSENIRGISALGMRALSLYYDTDESK
EGGVAFREKRKPDFRKFGK

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=275, Percent_Identity=35.6363636363636, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI31542718, Length=240, Percent_Identity=30.4166666666667, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI45643119, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI260275230, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI260274832, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=28.4615384615385, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI25453481, Length=215, Percent_Identity=26.5116279069767, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538573, Length=215, Percent_Identity=26.5116279069767, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4757966, Length=215, Percent_Identity=26.5116279069767, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538581, Length=215, Percent_Identity=26.5116279069767, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI70995211, Length=268, Percent_Identity=27.6119402985075, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=51.9083969465649, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1787659, Length=243, Percent_Identity=30.4526748971193, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI221142681, Length=262, Percent_Identity=30.9160305343511, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=28.4644194756554, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=31.6602316602317, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=32.9268292682927, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=32.3809523809524, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=244, Percent_Identity=32.7868852459016, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=211, Percent_Identity=27.9620853080569, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=26.5116279069767, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=174, Percent_Identity=32.7586206896552, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=263, Percent_Identity=26.9961977186312, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129971, Length=241, Percent_Identity=35.6846473029046, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653477, Length=241, Percent_Identity=35.6846473029046, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653139, Length=268, Percent_Identity=27.6119402985075, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357171, Length=182, Percent_Identity=29.6703296703297, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922422, Length=253, Percent_Identity=23.3201581027668, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24654903, Length=192, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650670, Length=180, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 28170; Mature: 28039

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTDILYEVRGGAAWITINRPDKYNAFRGHTVDELIHAFQTAGWDRKVGVIVLTGAGDK
CCHHHEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCC
AFCTGGDQSAHDGQYDGRGVIGLPIDELQSLIRDVPKPVIARVNGFAIGGGNVLATICDL
EEECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHCCCEEECCCHHEEHHHHH
TIASDKAQFGQVGPKVGSVDPGFGTAYLARVVGEKKAREIWYLNKRYSAAEALAMGLANA
HCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEEEECCHHHHHHHHHHHHHHH
VVPHEELDAEVDRWVAELMDRSPTALALAKVSFNADSENIRGISALGMRALSLYYDTDES
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHEEEEECCCCC
KEGGVAFREKRKPDFRKFGK
CCCCCEEHHCCCCCHHHCCC
>Mature Secondary Structure 
SYTDILYEVRGGAAWITINRPDKYNAFRGHTVDELIHAFQTAGWDRKVGVIVLTGAGDK
CHHHEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCC
AFCTGGDQSAHDGQYDGRGVIGLPIDELQSLIRDVPKPVIARVNGFAIGGGNVLATICDL
EEECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHCCCEEECCCHHEEHHHHH
TIASDKAQFGQVGPKVGSVDPGFGTAYLARVVGEKKAREIWYLNKRYSAAEALAMGLANA
HCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEEEECCHHHHHHHHHHHHHHH
VVPHEELDAEVDRWVAELMDRSPTALALAKVSFNADSENIRGISALGMRALSLYYDTDES
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHEEEEECCCCC
KEGGVAFREKRKPDFRKFGK
CCCCCEEHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]