Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 153951111

GI number: 153951111

Start: 1091127

End: 1091705

Strand: Direct

Name: tmk [H]

Synonym: JJD26997_1246

Alternate gene names: 153951111

Gene position: 1091127-1091705 (Clockwise)

Preceding gene: 153951621

Following gene: 153951862

Centisome position: 59.14

GC content: 30.4

Gene sequence:

>579_bases
TTGTATGTAGTTTTTGAAGGTATTGACTGCGTAGGGAAAAGTACGCAAATTTCACTTTTAAAAGAAATTTACAAAGACGC
CATTTTCACGCTCGAACCTGGTGGAACAGAGCTTGGTAAACACTTAAGAGAAATCTTACTTAATAAAACTCATCCTATCA
GCAAAAGAGCTGAGCTTTTGCTTTTTTTAGCTGATCGTGCTCAACATTTTGAAGAAATCTTAAAAACCAATCAAAACAAA
CTCATTATTAGTGATAGAAGTTTTATTTCAGGTATGGCTTATGCTAAAGATTTTGAAAACGATTTGCTTTTTACTTTAAA
TAGTTTTGCCTTAGAAGATTTTTTTCCACAAAAAATTATCTTTTTAAAAGGAGATGAAAACCTTATCCAAGAACGCCTCA
GTCAAAAAGAGCTAGATAGCATAGAAAAACGTGGCATTGAGTATTTTTTAAGCGTACAGGACAAACTCAAAAAAGTGCTT
CATTTTTTAAAAGAAAAAATTTCTATAGAAATTTTAACACTTGACGCAAAAGAAAGTAAAGAAAAATTACACCAACAAAT
AAAGGAATTTTTACAATGA

Upstream 100 bases:

>100_bases
CTTTTATTTCAAGTTCTATTGTTCGCTCTATCGTAGCACATGGAGGTGATGTAAGTTCTCTTGTTCCAAAAGAAATTCTA
CCTTTTTTAAAGGATCAATC

Downstream 100 bases:

>100_bases
TTAACGCTTTAAAAGGAATGAAAGATTTATTAGATAAAGATGCATATTATTATGAAAAAGTGATTCAAACCTGTGAAGAA
GTAGTTAAAAATTATGGCTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPISKRAELLLFLADRAQHFEEILKTNQNK
LIISDRSFISGMAYAKDFENDLLFTLNSFALEDFFPQKIIFLKGDENLIQERLSQKELDSIEKRGIEYFLSVQDKLKKVL
HFLKEKISIEILTLDAKESKEKLHQQIKEFLQ

Sequences:

>Translated_192_residues
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPISKRAELLLFLADRAQHFEEILKTNQNK
LIISDRSFISGMAYAKDFENDLLFTLNSFALEDFFPQKIIFLKGDENLIQERLSQKELDSIEKRGIEYFLSVQDKLKKVL
HFLKEKISIEILTLDAKESKEKLHQQIKEFLQ
>Mature_192_residues
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPISKRAELLLFLADRAQHFEEILKTNQNK
LIISDRSFISGMAYAKDFENDLLFTLNSFALEDFFPQKIIFLKGDENLIQERLSQKELDSIEKRGIEYFLSVQDKLKKVL
HFLKEKISIEILTLDAKESKEKLHQQIKEFLQ

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=28.7081339712919, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22350; Mature: 22350

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPISKRAELL
CEEEEECCCCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHH
LFLADRAQHFEEILKTNQNKLIISDRSFISGMAYAKDFENDLLFTLNSFALEDFFPQKII
HHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEE
FLKGDENLIQERLSQKELDSIEKRGIEYFLSVQDKLKKVLHFLKEKISIEILTLDAKESK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHH
EKLHQQIKEFLQ
HHHHHHHHHHHC
>Mature Secondary Structure
MYVVFEGIDCVGKSTQISLLKEIYKDAIFTLEPGGTELGKHLREILLNKTHPISKRAELL
CEEEEECCCCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHH
LFLADRAQHFEEILKTNQNKLIISDRSFISGMAYAKDFENDLLFTLNSFALEDFFPQKII
HHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEE
FLKGDENLIQERLSQKELDSIEKRGIEYFLSVQDKLKKVLHFLKEKISIEILTLDAKESK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHH
EKLHQQIKEFLQ
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA