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The map label for this gene is hisB

Identifier: 153935645

GI number: 153935645

Start: 1671034

End: 1671624

Strand: Direct

Name: hisB

Synonym: CLC_1599

Alternate gene names: 153935645

Gene position: 1671034-1671624 (Clockwise)

Preceding gene: 153936583

Following gene: 153935259

Centisome position: 44.44

GC content: 32.83

Gene sequence:

>591_bases
ATGAAGGAAAGCATAGCTAAAGTTTATAGAAAAACTGGAGAAACAGAAATAAAGTCGGAAATTAATTTATATGGAGAAGG
AAAATATGATATAAAAACCGGTATAGGTTTTTTTGATCATATGTTAAATCTTATGGCAAGGCATGGACTTATTGATGTAA
AACTAGAGGCAAAAGGTGACTTACAGGTAGATTCTCATCATACCGTGGAGGATGTAGGTATAGTTTTAGGTGAAAGTTTT
AAAAAAGCTCTAGGGGATAAAAAAGGTATTAAAAGATACGGAACTAGCTTTGTTCCTATGGATGAAGCCTTAGCCAGTGT
GTCTATAGATATAAGTGGAAGACCATATATAGTATGTGATTTTAACTTTACTGTAGACAAATTAGGCGAAATGGATACAG
AATTAGTGGAAGAATTTTTAAGAGCATTGGCTTTTAATGCTGGAATAACTTTACATGCTAGAGTATTATATGGTAAGAAT
AATCATCATATGATAGAAGCGGTTTTTAAAGCTTTAGGCAGAGCTCTTAGGGAAGCTGTAGATAGAGATGAAAAAATAAA
TGGGGTTATGTCTACTAAAGGTACACTATAG

Upstream 100 bases:

>100_bases
TAGATAAATAGTAGTTTAATATGTTTCCTATAAAAATACAATTGGAACAGTTTATAATTATTAAATAAAATTCATATGCC
ATGGAAAAGAGGATAAAGTT

Downstream 100 bases:

>100_bases
AAATGATAAATATGAATTATATTACAAACAATTATGTTTATTATTAAGTATTACGAGCTTTACAAGGAGTAATAGGGAAT
ATATAAAGCCGATAACATTA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESF
KKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGEMDTELVEEFLRALAFNAGITLHARVLYGKN
NHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL

Sequences:

>Translated_196_residues
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESF
KKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGEMDTELVEEFLRALAFNAGITLHARVLYGKN
NHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL
>Mature_196_residues
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESF
KKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGEMDTELVEEFLRALAFNAGITLHARVLYGKN
NHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=197, Percent_Identity=46.7005076142132, Blast_Score=184, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=40.4545454545455, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CLOB1 (A7FU78)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383911.1
- ProteinModelPortal:   A7FU78
- SMR:   A7FU78
- STRING:   A7FU78
- GeneID:   5395953
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1588
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   CBOT441770:CLB_1588-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21796; Mature: 21796

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGD
CCHHHHHHHHHCCCHHHHHHEEEECCCCEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LQVDSHHTVEDVGIVLGESFKKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCD
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHEEEEECCCCEEEEE
FNFTVDKLGEMDTELVEEFLRALAFNAGITLHARVLYGKNNHHMIEAVFKALGRALREAV
CCCCHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
DRDEKINGVMSTKGTL
CCHHHCCCHHCCCCCC
>Mature Secondary Structure
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGD
CCHHHHHHHHHCCCHHHHHHEEEECCCCEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LQVDSHHTVEDVGIVLGESFKKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCD
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHEEEEECCCCEEEEE
FNFTVDKLGEMDTELVEEFLRALAFNAGITLHARVLYGKNNHHMIEAVFKALGRALREAV
CCCCHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
DRDEKINGVMSTKGTL
CCHHHCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA