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The map label for this gene is hemB [H]

Identifier: 152976879

GI number: 152976879

Start: 3229864

End: 3230853

Strand: Reverse

Name: hemB [H]

Synonym: Bcer98_3178

Alternate gene names: 152976879

Gene position: 3230853-3229864 (Counterclockwise)

Preceding gene: 152976880

Following gene: 152976878

Centisome position: 79.05

GC content: 38.08

Gene sequence:

>990_bases
ATGAACTCTTTACAATTTAATCGTCATCGTCGTTTAAGACAAAGTGGAAATATGCGTGCACTTGTACGTGAAACATTTTT
ACATACGGAAGACTTTATTTACCCAATTTTCGTACTTGAAGGTGAAAATATTCGTAATGAAGTTCCTTCTATGCCAGGCG
TATATCAAGTTTCTTTAGATTTATTGCAAGCTGAAATGCAAGAAGTGGTTGATTTAGGCATTCGTTCTGTTATCGTATTT
GGCGTACCTGCTGAGAAGGACGAGATTGGATCTTCTGCATTTTGTGAACACGGCATTGTACAACGTGCGATTCAACAAAT
GAAAGAGCAATTTCCAGAGTTAGTAGTCATTGCGGATACATGCTTATGTCAATATACAAGCCATGGTCATTGCGGTGTAA
TTGAAGACGGTATTATTTTAAATGATCAATCGTTAGAAATTCTTGCAAAAACAGCTGTAAGTCAAGCGAAAGCAGGAGCA
GATATTATTGCTCCCTCTAACATGATGGACGGATTTGTAACGGCTATTCGTCATGCTTTAGATGAAAATGGTTTTTCACA
TGTGCCGGTTATGTCTTATGCAGTGAAATATGCATCTGCATTTTATGGGCCATTCCGTGATGCAGCGCATGGTGCACCGC
AATTTGGAGATCGCAAAACATATCAAATGGATCCAGCAAATCGAATGGAAGCATTCCGAGAAGCTGAATCAGATGTAATG
GAAGGAGCAGATTTCTTAATTGTAAAACCAGCTCTTTCTTATTTAGACATTGTTCGCGATGTGAAAAATAACTTTAATTT
ACCGATTGTTGCATATAATGTGAGCGGAGAATATTCGATGATTAAAGCAGCTGCTCAAAATGGCTGGATTAATGAAAAAG
AGATTGTCCTTGAAAAATTATTAAGTATGAAACGTGCGGGAGCAGATTTAATTATTACGTATCATGCAAAAGATGCCGCA
AGATGGTTACGAGAAGGGGGCGCACAATAA

Upstream 100 bases:

>100_bases
TGCTTGTTCCTGAAGAATATACGATAGAATCATTGATACAATGCATTTCCAAATTTTATGTGAATGCATAATGAAAATAA
AAGAATGGGGATAGAATTCT

Downstream 100 bases:

>100_bases
TGAAAAAGCTTGATAAATCGATTAAAGCGTTTGAAGAAGCACAAGATTTAATGCCTGGTGGTGTAAATAGTCCAGTTCGT
GCATTTAAATCGGTTGGGAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNSLQFNRHRRLRQSGNMRALVRETFLHTEDFIYPIFVLEGENIRNEVPSMPGVYQVSLDLLQAEMQEVVDLGIRSVIVF
GVPAEKDEIGSSAFCEHGIVQRAIQQMKEQFPELVVIADTCLCQYTSHGHCGVIEDGIILNDQSLEILAKTAVSQAKAGA
DIIAPSNMMDGFVTAIRHALDENGFSHVPVMSYAVKYASAFYGPFRDAAHGAPQFGDRKTYQMDPANRMEAFREAESDVM
EGADFLIVKPALSYLDIVRDVKNNFNLPIVAYNVSGEYSMIKAAAQNGWINEKEIVLEKLLSMKRAGADLIITYHAKDAA
RWLREGGAQ

Sequences:

>Translated_329_residues
MNSLQFNRHRRLRQSGNMRALVRETFLHTEDFIYPIFVLEGENIRNEVPSMPGVYQVSLDLLQAEMQEVVDLGIRSVIVF
GVPAEKDEIGSSAFCEHGIVQRAIQQMKEQFPELVVIADTCLCQYTSHGHCGVIEDGIILNDQSLEILAKTAVSQAKAGA
DIIAPSNMMDGFVTAIRHALDENGFSHVPVMSYAVKYASAFYGPFRDAAHGAPQFGDRKTYQMDPANRMEAFREAESDVM
EGADFLIVKPALSYLDIVRDVKNNFNLPIVAYNVSGEYSMIKAAAQNGWINEKEIVLEKLLSMKRAGADLIITYHAKDAA
RWLREGGAQ
>Mature_329_residues
MNSLQFNRHRRLRQSGNMRALVRETFLHTEDFIYPIFVLEGENIRNEVPSMPGVYQVSLDLLQAEMQEVVDLGIRSVIVF
GVPAEKDEIGSSAFCEHGIVQRAIQQMKEQFPELVVIADTCLCQYTSHGHCGVIEDGIILNDQSLEILAKTAVSQAKAGA
DIIAPSNMMDGFVTAIRHALDENGFSHVPVMSYAVKYASAFYGPFRDAAHGAPQFGDRKTYQMDPANRMEAFREAESDVM
EGADFLIVKPALSYLDIVRDVKNNFNLPIVAYNVSGEYSMIKAAAQNGWINEKEIVLEKLLSMKRAGADLIITYHAKDAA
RWLREGGAQ

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=322, Percent_Identity=45.3416149068323, Blast_Score=281, Evalue=5e-76,
Organism=Escherichia coli, GI87081728, Length=315, Percent_Identity=52.3809523809524, Blast_Score=307, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=44.5820433436532, Blast_Score=260, Evalue=3e-70,
Organism=Drosophila melanogaster, GI21358291, Length=309, Percent_Identity=40.7766990291262, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36651; Mature: 36651

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLQFNRHRRLRQSGNMRALVRETFLHTEDFIYPIFVLEGENIRNEVPSMPGVYQVSLD
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCCCCCHHHHHHH
LLQAEMQEVVDLGIRSVIVFGVPAEKDEIGSSAFCEHGIVQRAIQQMKEQFPELVVIADT
HHHHHHHHHHHHCHHHEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHH
CLCQYTSHGHCGVIEDGIILNDQSLEILAKTAVSQAKAGADIIAPSNMMDGFVTAIRHAL
HHHHCCCCCCCCEECCCEEECCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHH
DENGFSHVPVMSYAVKYASAFYGPFRDAAHGAPQFGDRKTYQMDPANRMEAFREAESDVM
HCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHH
EGADFLIVKPALSYLDIVRDVKNNFNLPIVAYNVSGEYSMIKAAAQNGWINEKEIVLEKL
CCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHH
LSMKRAGADLIITYHAKDAARWLREGGAQ
HHHHHCCCCEEEEEECHHHHHHHHHCCCC
>Mature Secondary Structure
MNSLQFNRHRRLRQSGNMRALVRETFLHTEDFIYPIFVLEGENIRNEVPSMPGVYQVSLD
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCCCCCHHHHHHH
LLQAEMQEVVDLGIRSVIVFGVPAEKDEIGSSAFCEHGIVQRAIQQMKEQFPELVVIADT
HHHHHHHHHHHHCHHHEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHH
CLCQYTSHGHCGVIEDGIILNDQSLEILAKTAVSQAKAGADIIAPSNMMDGFVTAIRHAL
HHHHCCCCCCCCEECCCEEECCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHH
DENGFSHVPVMSYAVKYASAFYGPFRDAAHGAPQFGDRKTYQMDPANRMEAFREAESDVM
HCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHH
EGADFLIVKPALSYLDIVRDVKNNFNLPIVAYNVSGEYSMIKAAAQNGWINEKEIVLEKL
CCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHH
LSMKRAGADLIITYHAKDAARWLREGGAQ
HHHHHCCCCEEEEEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377 [H]