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The map label for this gene is serS [H]

Identifier: 152969482

GI number: 152969482

Start: 1038711

End: 1040003

Strand: Direct

Name: serS [H]

Synonym: KPN_00925

Alternate gene names: 152969482

Gene position: 1038711-1040003 (Clockwise)

Preceding gene: 152969481

Following gene: 152969483

Centisome position: 19.54

GC content: 57.93

Gene sequence:

>1293_bases
ATGCTCGATCCCAATCTGCTGCGTACCGAGCCAGACGCAGTCGCAGAAAAACTGGCACGCCGGGGCTTTAAGCTGGATGT
AGATAAACTTCGCGCGCTTGAAGAGCGTCGTAAAGTTCTGCAGGTGCAAACGGAAAACCTGCAGGCGGAGCGTAACTCCC
GATCGAAATCCATTGGCCAGGCGAAAGCGCGCGGGGAAGACATCGAGCCATTACGCCTGGAAGTTAACAAGCTTGGCGAA
CAACTGGATGCTGCAAAATCCGAGCTGGAAACGCTGCTGGCGGAAATTCGCGATATCGCGCTGGCGATCCCGAATATTCC
TCATGATGATGTGCCGGTTGGTCGCGATGAAAACGACAACGTTGAAGTTAGCCGCTGGGGTACGCCGCGTCAGTTCGATT
TTGAGGTGCGCGATCATGTGACGCTGGGTGAAATGCACGGGGGGCTGGATTTTGCCGCCGCCGTTAAGCTCACCGGCTCG
CGCTTCGTGGTGATGAAAGGGCAGCTGGCCCGTCTGCACCGCGCCCTGGCGCAGTTCATGCTGGATCTGCACACCGAACA
GCATGGCTACAGCGAAAACTATGTCCCGTACCTGGTAAACCAGGACACCCTGTATGGCACTGGCCAGCTGCCGAAATTCG
CCGGCGACCTGTTCCATACCCGTCCGCTGGAAGAAGAGGCTGACAGCAGCAACTACGCGCTGATCCCGACGGCGGAAGTG
CCGCTGACCAACCTGGTGCGCGATGAAATCATCGACGAAGACGATCTGCCGATCAAAATGACCGCCCATACGCCGTGCTT
CCGCTCTGAAGCCGGTTCCTATGGCCGCGACACCCGCGGTCTGATCCGTATGCACCAGTTCGATAAAGTTGAAATGGTGC
AGATCGTCCGCCCGGAAGACTCTATGGCCGCGCTGGAAGAGATGACCGGTCACGCCGAGAAAGTGCTGCAGCTGCTGGGC
CTGCCGTACCGTAAGGTCGCGCTGTGCACCGGCGATATGGGCTTCAGCGCCTGCAAAACCTATGACCTCGAAGTATGGGT
TCCGGCGCAAAACACTTATCGTGAGATCTCCTCCTGCTCCAACGTCTGGGATTTCCAGGCGCGTCGTATGCAGGCTCGCT
GCCGCAGCAAGTCCGATAAGAAGACCCGTCTCGTTCATACCCTGAATGGTTCTGGCCTGGCAGTAGGTCGTACCCTGGTG
GCGCTGATGGAAAACTATCAGCAGGCTGATGGCCGTATCGAGATCCCGGAAGTGCTGCGCCCGTATATGCGCGGCCTCGA
ATATATCGGCTAA

Upstream 100 bases:

>100_bases
CTACCGCTAATTGAGGCGTTGCGGTAAGGTTATTACACTATTTCCGTGGTCGTAGTCTGCGGCCACTTTTCTTTTTTAAT
TCGATAAGCACAGGATAAGC

Downstream 100 bases:

>100_bases
ACTTCTCACTCCTTCTTTTAAAAGCGCCTGCGGGCGCTTTTTTTACGCCCTTATTGATACCGGGCAATAATCCTTTTCGC
GAATGCAGTGATACTCCCTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
QLDAAKSELETLLAEIRDIALAIPNIPHDDVPVGRDENDNVEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFAAAVKLTGS
RFVVMKGQLARLHRALAQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
PLTNLVRDEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKVALCTGDMGFSACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
ALMENYQQADGRIEIPEVLRPYMRGLEYIG

Sequences:

>Translated_430_residues
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
QLDAAKSELETLLAEIRDIALAIPNIPHDDVPVGRDENDNVEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFAAAVKLTGS
RFVVMKGQLARLHRALAQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
PLTNLVRDEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKVALCTGDMGFSACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
ALMENYQQADGRIEIPEVLRPYMRGLEYIG
>Mature_430_residues
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
QLDAAKSELETLLAEIRDIALAIPNIPHDDVPVGRDENDNVEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFAAAVKLTGS
RFVVMKGQLARLHRALAQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
PLTNLVRDEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKVALCTGDMGFSACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
ALMENYQQADGRIEIPEVLRPYMRGLEYIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=438, Percent_Identity=33.5616438356164, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI8923421, Length=327, Percent_Identity=31.8042813455657, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI225579074, Length=327, Percent_Identity=31.8042813455657, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=93.7209302325581, Blast_Score=847, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=30.4721030042918, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=353, Percent_Identity=31.4447592067989, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6321799, Length=414, Percent_Identity=30.9178743961353, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320226, Length=404, Percent_Identity=31.1881188118812, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24581334, Length=469, Percent_Identity=31.9829424307036, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17737985, Length=272, Percent_Identity=36.7647058823529, Blast_Score=161, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48604; Mature: 48604

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAERNSRSKSIGQ
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDIEPLRLEVNKLGEQLDAAKSELETLLAEIRDIALAIPNIPHDDVPVGRDENDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFAAAVKLTGSRFVVMKGQLARLHRALAQFM
EEEEECCCCCEECCHHHCCEEEHHHCCCCCHHHEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
HHHHHHHCCCCCCCCCEEECCCCEECCCCCCHHHHHHHCCCCCCHHCCCCCEEEEECCCC
PLTNLVRDEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
CHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCH
SMAALEEMTGHAEKVLQLLGLPYRKVALCTGDMGFSACKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHCHHHHHHHHHCCCCHHEEEEECCCCCHHHEEECEEEEECCHHHHHHHHHHH
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVALMENYQQADGRIEIPEVLR
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHH
PYMRGLEYIG
HHHHHHHCCC
>Mature Secondary Structure
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAERNSRSKSIGQ
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDIEPLRLEVNKLGEQLDAAKSELETLLAEIRDIALAIPNIPHDDVPVGRDENDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFAAAVKLTGSRFVVMKGQLARLHRALAQFM
EEEEECCCCCEECCHHHCCEEEHHHCCCCCHHHEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
HHHHHHHCCCCCCCCCEEECCCCEECCCCCCHHHHHHHCCCCCCHHCCCCCEEEEECCCC
PLTNLVRDEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
CHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCH
SMAALEEMTGHAEKVLQLLGLPYRKVALCTGDMGFSACKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHCHHHHHHHHHCCCCHHEEEEECCCCCHHHEEECEEEEECCHHHHHHHHHHH
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVALMENYQQADGRIEIPEVLR
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHH
PYMRGLEYIG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA