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The map label for this gene is dmsA [H]

Identifier: 152969483

GI number: 152969483

Start: 1040204

End: 1042642

Strand: Direct

Name: dmsA [H]

Synonym: KPN_00926

Alternate gene names: 152969483

Gene position: 1040204-1042642 (Clockwise)

Preceding gene: 152969482

Following gene: 152969484

Centisome position: 19.57

GC content: 58.02

Gene sequence:

>2439_bases
ATGAAAATTAAAGCCCCTGATGCTTTACTGGCTGCTGAGGTAAGCCGCCGTGGTCTGATGAAAACCACGGCAATAGGCGG
CCTGGCGCTGGCCAGCAACGCACTAACGTTACCTTTTACCCGACTGTCGCATGCTGACGATACGCCGGCGCCCGCCAGTG
AGAAGGTGGTCTGGAGCGCCTGCACCGTCAACTGCGGTAGCCGTTGCCCGCTGCGCATGCACGTGGTGGATGGCGCGATT
AAATACGTCGAAACCGATAATACCGGTGATGATAACTATGACGGTTTGCACCAGGTCCGCGCCTGCCTGCGTGGGCGTTC
AATGCGCCGCCGGGTCTATAATCCGGACCGTCTGAAGTACCCGATGAAGCGCGTTGGTAAACGCGGTGAGGGCAAGTTCG
AGCAAATCAGCTGGGAAGAGGCGTTGGATACCATCGCCAGCAATATGCAGCGGCTGATTAAAGAGTACGGCAACGAATCC
ATCTATCTGAACTACGGCACCGGCACGCTCGGCGGGACGCTGACCCGCTCCTGGCCGCCGGGGAAAACGCTGATTGCCCG
TCTGATGAACTGCTGCGGTGGCTATCTCAACCATTATGGCGACTATTCATCAGCGCAGATTGCTGCCGGTCTGAATTACA
CCTACGGCGGCTGGGCGGACGGCAACAGCCCATCGGATATTGAAAACAGTCAGCTGGTGGTGCTGTTCGGCAATAACCCC
GGCGAAACGCGGATGAGCGGCGGCGGGGTGACGTACTACCTTGAACAGGCGCGGCAGAAATCCAATGCCCGGATGATAAT
CATCGATCCGCGCTATACCGACACCGGCGCCGGGCGTGAAGATGAATGGATCCCGATTCGTCCGGGGACCGATGCGGCAC
TGGTTTCGGGCCTCGCGTGGGTGATGATCACCGAGAATCTGGTCGATCAGCCGTTTCTCGATAAATACTGCGTGGGATAC
GACGAGAAAACGCTGCCCGCCGGTGCGCCAGCCAATGGTCATTACAAAGCTTACATTCTTGGCCAGGGCACTGACGGTAT
CGCCAAAACGCCGGAGTGGGCCTCGACAATTACCGGTATTCCGCGCGAACGCATTGTTAAACTGGCGCGCGAAATTGCCA
CCGCCAAACCGGCCTATATTAGCCAGGGCTGGGGTCCGCAGCGTCACGCCAACGGTGAGATCGCCACCCGCGCCATCTCA
ATGCTCGCCATTCTGACGGGTAACGTCGGGATCAACGGCGGCAATAGCGGGGCGCGCGAGGGCTCGTATAGTTTGCCTTT
TGAGCGTATGCCGACGCTGGAGAATCCGGTTGAGACCAGTATCTCGATGTTTATGTGGACCGATGCGATTGAGCGCGGCC
CGGAAATGACCGCTCTGCGCGACGGCGTACGCGGTAAAGATAAGCTCGACGTGCCGATCAAAATGATCTGGAACTATGCG
GGCAACTGTCTGATTAACCAGCATTCTGAGATCAACCGGACCCACGAAATCCTGCAGGACGACAAGAAATGCGAGATGAT
TGTGGTCATTGACTGCCATATGACCTCCTCGGCGAAATACGCTGATATTCTGCTGCCGGACTGTACCGCCTCCGAGCAGA
TGGATTTCGCGCTGGATGCCTCCTGCGGCAACATGTCCTACGTTATCTTTGCCGATCAGGCCATCAAGCCGCGCTTTGAA
TGCAAAACCATCTATGAGATGACCAGCGAACTGGCAAAGCGTCTGGGCGTCGAAGAGCAGTTTACCGAGGGCCGTACCCA
GGAAGGCTGGATGCGCTATCTGTATGAGCAGTCGCGCAAAGCGATTCCCGACCTGCCGGATTTCGACACCTTCCGTCAGC
AGGGCATCTATAAGCAGCGCGATCCGCAAGGTCATCATGTGGCCTACAAAGCCTTCCGTGAGGATCCGCAGGCTAATCCG
CTGACCACGCCTTCGGGCAAGATCGAAATTTACTCGCAGGATCTGGCGAAAATCGCGGCCACCTGGGAGCTGCCGGAAGG
GGATGTTATCGATCCGCTGCCGATCTACACCCCGGGTTTCGAAAACTACAACGATCCGCTGACAGCGAAATACCCGCTAC
AGCTCACCGGCTTCCACTATAAATCTCGCGTCCACTCGACCTACGGCAACGTCGATGTGCTGAAGGCCGCCTGTCGGCAG
GAGATGTGGATTAACCCGATCGATGCCCGCAAGCGCGGCATTGCCAACGGCGATCGTATTCGCATCTTCAACGATCGGGG
TGAAGTGCATATCGAAGCGAAGGTGACGCCGCGCATGATGCCGGGCGTCGTCGCGCTGGGGGAAGGGGCCTGGTACAACC
CGGACGCCTCGCGTGTGGATCAGGCGGGCAGCATCAACGTGCTGACCACCCAGCGTCCGTCGCCGCTGGCGAAGGGAAAC
CCGTCGCATACCAACCTCGTTCAGGTTGAGAAGCTGTAA

Upstream 100 bases:

>100_bases
TGGATTAAACCAGCATAAAAAACCAATAATATCGCAAAGCATTATATATATGTCTATATAACGCTTGTCAGTTTATTGTG
AGCAACCAAAGCGAGTATCC

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACTCAGTATGGATTTTTTATTGATTCCGCCCGTTGCACCGGTTGCAAAACCTGCGAACTGGCCT
GTAAGGACTACAAGAACCTG

Product: anaerobic dimethyl sulfoxide (DMSO) reductase, subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 812; Mature: 812

Protein sequence:

>812_residues
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHADDTPAPASEKVVWSACTVNCGSRCPLRMHVVDGAI
KYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNES
IYLNYGTGTLGGTLTRSWPPGKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAWVMITENLVDQPFLDKYCVGY
DEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGIPRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAIS
MLAILTGNVGINGGNSGAREGSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFADQAIKPRFE
CKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRKAIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANP
LTTPSGKIEIYSQDLAKIAATWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVDQAGSINVLTTQRPSPLAKGN
PSHTNLVQVEKL

Sequences:

>Translated_812_residues
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHADDTPAPASEKVVWSACTVNCGSRCPLRMHVVDGAI
KYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNES
IYLNYGTGTLGGTLTRSWPPGKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAWVMITENLVDQPFLDKYCVGY
DEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGIPRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAIS
MLAILTGNVGINGGNSGAREGSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFADQAIKPRFE
CKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRKAIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANP
LTTPSGKIEIYSQDLAKIAATWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVDQAGSINVLTTQRPSPLAKGN
PSHTNLVQVEKL
>Mature_812_residues
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHADDTPAPASEKVVWSACTVNCGSRCPLRMHVVDGAI
KYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNES
IYLNYGTGTLGGTLTRSWPPGKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAWVMITENLVDQPFLDKYCVGY
DEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGIPRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAIS
MLAILTGNVGINGGNSGAREGSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFADQAIKPRFE
CKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRKAIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANP
LTTPSGKIEIYSQDLAKIAATWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVDQAGSINVLTTQRPSPLAKGN
PSHTNLVQVEKL

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=814, Percent_Identity=89.8034398034398, Blast_Score=1532, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=803, Percent_Identity=67.6214196762142, Blast_Score=1149, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=816, Percent_Identity=66.0539215686274, Blast_Score=1141, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=765, Percent_Identity=31.8954248366013, Blast_Score=299, Evalue=5e-82,
Organism=Escherichia coli, GI87081994, Length=856, Percent_Identity=30.607476635514, Blast_Score=292, Evalue=5e-80,
Organism=Escherichia coli, GI145693196, Length=752, Percent_Identity=30.8510638297872, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI3868721, Length=781, Percent_Identity=24.8399487836108, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI3868720, Length=467, Percent_Identity=26.1241970021413, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788534, Length=842, Percent_Identity=22.6840855106888, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI3868719, Length=463, Percent_Identity=25.0539956803456, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787477, Length=351, Percent_Identity=25.0712250712251, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787741, Length=307, Percent_Identity=24.7557003257329, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 90018; Mature: 90018

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHADDTPAPASEKVVWSA
CCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHCCCEECCHHHHCCCCCCCCCCCCCEEEEE
CTVNCGSRCPLRMHVVDGAIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKY
EEECCCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCHHHCC
PMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNESIYLNYGTGTLGGTLTRSWPP
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCC
GKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAW
CCCEECCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
VMITENLVDQPFLDKYCVGYDEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGI
EEEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCC
PRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGARE
CHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHCCC
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDA
CCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEC
SCGNMSYVIFADQAIKPRFECKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHH
AIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQDLAKIAA
CCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHH
TWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EEECCCCCCCCCCCCCCCCCCCCCCCCCEECCEEEECCHHHHHHHHCCCCHHHHHHHHHH
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVD
HHCCCCHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHHHC
QAGSINVLTTQRPSPLAKGNPSHTNLVQVEKL
CCCCEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHADDTPAPASEKVVWSA
CCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHCCCEECCHHHHCCCCCCCCCCCCCEEEEE
CTVNCGSRCPLRMHVVDGAIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKY
EEECCCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCHHHCC
PMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNESIYLNYGTGTLGGTLTRSWPP
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCC
GKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAW
CCCEECCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
VMITENLVDQPFLDKYCVGYDEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGI
EEEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCC
PRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGARE
CHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHCCC
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDA
CCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEC
SCGNMSYVIFADQAIKPRFECKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHH
AIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQDLAKIAA
CCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHH
TWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EEECCCCCCCCCCCCCCCCCCCCCCCCCEECCEEEECCHHHHHHHHCCCCHHHHHHHHHH
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVD
HHCCCCHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHHHC
QAGSINVLTTQRPSPLAKGNPSHTNLVQVEKL
CCCCEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]