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The map label for this gene is nqo3 [H]

Identifier: 150396119

GI number: 150396119

Start: 966399

End: 968480

Strand: Direct

Name: nqo3 [H]

Synonym: Smed_0896

Alternate gene names: 150396119

Gene position: 966399-968480 (Clockwise)

Preceding gene: 150396118

Following gene: 150396120

Centisome position: 25.55

GC content: 63.64

Gene sequence:

>2082_bases
ATGGCAAAGCTGAAAGTCGACGGAAAAGAGATCGAGGTCCCGGATCATTTCACGCTGCTTCAGGCATGCGAGGAGGCCGG
CGCCGAGGTTCCGCGCTTCTGTTTCCATGAGCGGCTTTCGGTTGCCGGCAACTGCCGCATGTGTCTGATCGAGGTGAAGG
GCGGACCGCCGAAGCCGGCGGCTTCCTGTGCCATGGGCGTGCGCGACCTTCGTCCCGGTCCGAACGGCGAGACGCCGGAA
GTCTTCACGACCACACCGATGGTCAAGAAGGCGCGCGAGGGCGTCATGGAGTTCCTGCTCATCAACCACCCGCTGGACTG
CCCGATCTGCGACCAGGGCGGCGAGTGCGACCTTCAGGACCAGGCGATGGCGTTCGGCATCGACAGCTCGCGCTATCAGG
AAAACAAGCGCGCGGTCGAGGACAAATATATCGGTCCGCTCGTCAAGACCGTGATGAACCGCTGCATCCACTGCACGCGT
TGCGTGAGGTTCACGACGGAAGTCGCCGGCATCGCCGAACTCGGCCTGATCGGCCGCGGCGAGGACGCCGAGATCACCAC
CTATCTCGAGCAGGCGATGACCTCGGAACTGCAGGGCAACGTCGTTGACCTCTGCCCGGTCGGCGCGCTGACATCGAAGC
CATTCTCCTTTACCGCGCGCCCGTGGGAGCTCGGCAAGACCGAGTCGATCGATGTCATGGATGCCGTCGGCTCGGCGATC
CGCGTCGATACGCGCGGCCGCGAAGTCATGCGGGTCATGCCGCGGGTCAACGAGGAGATCAACGAAGAGTGGATCTCCGA
CAAGACCCGCTTCATCTGGGACGGCCTCAAGACGCAGCGTCTGGACCGCCCCTATGTCAAGAAGGACGGCCGACTGCAGC
AGGCAAGCTGGGCAGAGGCTTTCCAGGCGATCAAGGCCGCCATTGCCGCCACGTCCGGTGACAGGATCGGCGCGATCGCA
GGCGATCTCGCTTCTGTCGAGGAAATGTATGCGCTGAAGGAACTCGTCGCCTCGCTCGGCTCCGAGAATCTCGACTGCCG
TCAGGACGGTGCAGCACTCGACCCGTCGCTCGGCCGCGCCAGCTACATCTTCAACCCGACCATCCAGGGTATCGAAGACG
CCGATGCGCTCATCATCATCGGCTCCAATCCGCGCTTCGAAGCCTCGGTTCTCAATGCTCGCATCCGCAAGCGCCATCGC
ATGGGCAACTTCCCCATAGGCGTGATCGGCGAGCCGGGCGAACTGCGTTACGATTACGAGTATCTTGGCGCGGGTGCCGA
TACACTCGCCGAGCTCGTTTCCGGCAAGGCCAAGTTCTTCGCGACGCTTGAAAAGGCTGCGCGTCCGCTGATCATTGTCG
GCCAGGGTGCTCTTGCAGGGGAGGGCGGCGCGGCCGTACTCGCCAATGCGGCGAAGCTTGCCGTTGCAGTCGGCGCCGTG
AACGCCGAGTGGAACGGATTTGCCGTGCTTCACACCGCGGCCGCCCGCGTCGGCGGTCTCGATCTCGGCTTCGTGCCGGG
CGGGAGCGGCAAGCCGGCCGGCGAAATGGTCGAGGGCACGGATGTCCTTTTCCTGCTCGGGGCCGACGAGATCGACCTCT
CCGCCAGGAAGGCCGGCTTTACCGTTTATATCGGTTCGCACGGCGACAACGGCGCGCACGCCGCGGACGTCATCCTTCCC
GGCGCGACCTACACGGAAAAGTCCGGCACATGGGTGAACACCGAGGGACGCGTACAGATCGGCAACCGCGCCGCTTTCGC
ACCGGGCGAAGCCCGCGAAGACTGGGCCATTATTCGTGCGCTTTCCGACGTGCTCGGCAAGAAGCTGCCCTTCGACTCGC
TTGGAGAATTGCGCGCTAAACTCTATGCCGCCCATCCGCATTTCGCCGTGCCAGACGAGATCGCCGCCGGCAGCAGCGAC
GAAATTGCCGCACTTGCCCAAAAAGCCGGTGCGATGGCGAAATCCGTGTTTGCGTCTCCGGTCAAAGACTTCTATTTGAC
GAACCCGATAGCGCGCGCGTCCGCCGTCATGGCCGAGTGCTCGGCCTTGGCGCGCAACAATTTCAAAGCTGCCGCGGAAT
GA

Upstream 100 bases:

>100_bases
CGGCAGGCGGCGAGACCGTGAAGGAATTGTCCGTCGCGTCCTGCAGGACGCGCGGCGCTGTAGATAAGCAGACGGACTGA
AGACAGGATTGAGTACGAAG

Downstream 100 bases:

>100_bases
GCGCGAGGGAATAGAGCATCATGGACGCTTTCTTTTCGACCTATGTCTGGCCAACGGCCATCATGATCGGCCAGTCGCTC
CTGCTTCTGGTCGCGCTGCT

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MAKLKVDGKEIEVPDHFTLLQACEEAGAEVPRFCFHERLSVAGNCRMCLIEVKGGPPKPAASCAMGVRDLRPGPNGETPE
VFTTTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAFGIDSSRYQENKRAVEDKYIGPLVKTVMNRCIHCTR
CVRFTTEVAGIAELGLIGRGEDAEITTYLEQAMTSELQGNVVDLCPVGALTSKPFSFTARPWELGKTESIDVMDAVGSAI
RVDTRGREVMRVMPRVNEEINEEWISDKTRFIWDGLKTQRLDRPYVKKDGRLQQASWAEAFQAIKAAIAATSGDRIGAIA
GDLASVEEMYALKELVASLGSENLDCRQDGAALDPSLGRASYIFNPTIQGIEDADALIIIGSNPRFEASVLNARIRKRHR
MGNFPIGVIGEPGELRYDYEYLGAGADTLAELVSGKAKFFATLEKAARPLIIVGQGALAGEGGAAVLANAAKLAVAVGAV
NAEWNGFAVLHTAAARVGGLDLGFVPGGSGKPAGEMVEGTDVLFLLGADEIDLSARKAGFTVYIGSHGDNGAHAADVILP
GATYTEKSGTWVNTEGRVQIGNRAAFAPGEAREDWAIIRALSDVLGKKLPFDSLGELRAKLYAAHPHFAVPDEIAAGSSD
EIAALAQKAGAMAKSVFASPVKDFYLTNPIARASAVMAECSALARNNFKAAAE

Sequences:

>Translated_693_residues
MAKLKVDGKEIEVPDHFTLLQACEEAGAEVPRFCFHERLSVAGNCRMCLIEVKGGPPKPAASCAMGVRDLRPGPNGETPE
VFTTTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAFGIDSSRYQENKRAVEDKYIGPLVKTVMNRCIHCTR
CVRFTTEVAGIAELGLIGRGEDAEITTYLEQAMTSELQGNVVDLCPVGALTSKPFSFTARPWELGKTESIDVMDAVGSAI
RVDTRGREVMRVMPRVNEEINEEWISDKTRFIWDGLKTQRLDRPYVKKDGRLQQASWAEAFQAIKAAIAATSGDRIGAIA
GDLASVEEMYALKELVASLGSENLDCRQDGAALDPSLGRASYIFNPTIQGIEDADALIIIGSNPRFEASVLNARIRKRHR
MGNFPIGVIGEPGELRYDYEYLGAGADTLAELVSGKAKFFATLEKAARPLIIVGQGALAGEGGAAVLANAAKLAVAVGAV
NAEWNGFAVLHTAAARVGGLDLGFVPGGSGKPAGEMVEGTDVLFLLGADEIDLSARKAGFTVYIGSHGDNGAHAADVILP
GATYTEKSGTWVNTEGRVQIGNRAAFAPGEAREDWAIIRALSDVLGKKLPFDSLGELRAKLYAAHPHFAVPDEIAAGSSD
EIAALAQKAGAMAKSVFASPVKDFYLTNPIARASAVMAECSALARNNFKAAAE
>Mature_692_residues
AKLKVDGKEIEVPDHFTLLQACEEAGAEVPRFCFHERLSVAGNCRMCLIEVKGGPPKPAASCAMGVRDLRPGPNGETPEV
FTTTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAFGIDSSRYQENKRAVEDKYIGPLVKTVMNRCIHCTRC
VRFTTEVAGIAELGLIGRGEDAEITTYLEQAMTSELQGNVVDLCPVGALTSKPFSFTARPWELGKTESIDVMDAVGSAIR
VDTRGREVMRVMPRVNEEINEEWISDKTRFIWDGLKTQRLDRPYVKKDGRLQQASWAEAFQAIKAAIAATSGDRIGAIAG
DLASVEEMYALKELVASLGSENLDCRQDGAALDPSLGRASYIFNPTIQGIEDADALIIIGSNPRFEASVLNARIRKRHRM
GNFPIGVIGEPGELRYDYEYLGAGADTLAELVSGKAKFFATLEKAARPLIIVGQGALAGEGGAAVLANAAKLAVAVGAVN
AEWNGFAVLHTAAARVGGLDLGFVPGGSGKPAGEMVEGTDVLFLLGADEIDLSARKAGFTVYIGSHGDNGAHAADVILPG
ATYTEKSGTWVNTEGRVQIGNRAAFAPGEAREDWAIIRALSDVLGKKLPFDSLGELRAKLYAAHPHFAVPDEIAAGSSDE
IAALAQKAGAMAKSVFASPVKDFYLTNPIARASAVMAECSALARNNFKAAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=700, Percent_Identity=49.4285714285714, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI145693161, Length=646, Percent_Identity=28.0185758513932, Blast_Score=199, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17565758, Length=702, Percent_Identity=49.1452991452991, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32566231, Length=608, Percent_Identity=50.328947368421, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI193209088, Length=256, Percent_Identity=60.546875, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24640559, Length=684, Percent_Identity=49.8538011695906, Blast_Score=635, Evalue=0.0,
Organism=Drosophila melanogaster, GI24640557, Length=684, Percent_Identity=49.8538011695906, Blast_Score=635, Evalue=0.0,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73991; Mature: 73860

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLKVDGKEIEVPDHFTLLQACEEAGAEVPRFCFHERLSVAGNCRMCLIEVKGGPPKPA
CCEEECCCCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
ASCAMGVRDLRPGPNGETPEVFTTTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAFGIDSSRYQENKRAVEDKYIGPLVKTVMNRCIHCTRCVRFTTEVAGIAELGLIGRG
CHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDAEITTYLEQAMTSELQGNVVDLCPVGALTSKPFSFTARPWELGKTESIDVMDAVGSAI
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEE
RVDTRGREVMRVMPRVNEEINEEWISDKTRFIWDGLKTQRLDRPYVKKDGRLQQASWAEA
EECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHH
FQAIKAAIAATSGDRIGAIAGDLASVEEMYALKELVASLGSENLDCRQDGAALDPSLGRA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SYIFNPTIQGIEDADALIIIGSNPRFEASVLNARIRKRHRMGNFPIGVIGEPGELRYDYE
EEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECHH
YLGAGADTLAELVSGKAKFFATLEKAARPLIIVGQGALAGEGGAAVLANAAKLAVAVGAV
HHCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHEEEEECC
NAEWNGFAVLHTAAARVGGLDLGFVPGGSGKPAGEMVEGTDVLFLLGADEIDLSARKAGF
CCCCCCEEEEEHHHHHHCCCEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCCCCCE
TVYIGSHGDNGAHAADVILPGATYTEKSGTWVNTEGRVQIGNRAAFAPGEAREDWAIIRA
EEEEECCCCCCCCEEEEEECCCCEECCCCCEECCCCCEEECCEEECCCCCCCHHHHHHHH
LSDVLGKKLPFDSLGELRAKLYAAHPHFAVPDEIAAGSSDEIAALAQKAGAMAKSVFASP
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VKDFYLTNPIARASAVMAECSALARNNFKAAAE
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKLKVDGKEIEVPDHFTLLQACEEAGAEVPRFCFHERLSVAGNCRMCLIEVKGGPPKPA
CEEECCCCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
ASCAMGVRDLRPGPNGETPEVFTTTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAFGIDSSRYQENKRAVEDKYIGPLVKTVMNRCIHCTRCVRFTTEVAGIAELGLIGRG
CHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDAEITTYLEQAMTSELQGNVVDLCPVGALTSKPFSFTARPWELGKTESIDVMDAVGSAI
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEE
RVDTRGREVMRVMPRVNEEINEEWISDKTRFIWDGLKTQRLDRPYVKKDGRLQQASWAEA
EECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHH
FQAIKAAIAATSGDRIGAIAGDLASVEEMYALKELVASLGSENLDCRQDGAALDPSLGRA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SYIFNPTIQGIEDADALIIIGSNPRFEASVLNARIRKRHRMGNFPIGVIGEPGELRYDYE
EEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECHH
YLGAGADTLAELVSGKAKFFATLEKAARPLIIVGQGALAGEGGAAVLANAAKLAVAVGAV
HHCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHEEEEECC
NAEWNGFAVLHTAAARVGGLDLGFVPGGSGKPAGEMVEGTDVLFLLGADEIDLSARKAGF
CCCCCCEEEEEHHHHHHCCCEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCCCCCE
TVYIGSHGDNGAHAADVILPGATYTEKSGTWVNTEGRVQIGNRAAFAPGEAREDWAIIRA
EEEEECCCCCCCCEEEEEECCCCEECCCCCEECCCCCEEECCEEECCCCCCCHHHHHHHH
LSDVLGKKLPFDSLGELRAKLYAAHPHFAVPDEIAAGSSDEIAALAQKAGAMAKSVFASP
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VKDFYLTNPIARASAVMAECSALARNNFKAAAE
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]