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The map label for this gene is nuoF1 [H]

Identifier: 150396117

GI number: 150396117

Start: 964304

End: 965608

Strand: Direct

Name: nuoF1 [H]

Synonym: Smed_0894

Alternate gene names: 150396117

Gene position: 964304-965608 (Clockwise)

Preceding gene: 150396116

Following gene: 150396118

Centisome position: 25.5

GC content: 62.61

Gene sequence:

>1305_bases
ATGCTTAAAGACGAAGATCGCATCTTTACCAACATCTACGGCCTCATGGACAAGTCGCTCAAGGGCGCGATGGCGCGAGG
CCATTGGGACGGCACGAAGCAGTTCCTGGAAAAGGGCCGCGACTGGATCATCAACGAGGTGAAGGCTTCCGGCCTCCGCG
GCCGCGGCGGCGCCGGCTTCCCGACCGGTCTCAAATGGTCCTTCATGCCGAAGGAGAGCGACGGGCGCCCGCATTACCTC
GTCGTCAATGCCGACGAGTCCGAGCCCGGCACCTGCAAGGACCGCGACATCATGCGCCACGATCCGCACACGCTGATCGA
GGGCTGCGTGATTGCGAGCTTCGCGATGGGTGCGCATGCCGCCTATATCTATGTTCGCGGCGAGTTCATCCGCGAGCGCG
AAGCGCTGCAGGCTGCGATCGACGAATGTTACGCATACGGCCTGCTCGGAAAGAACAACAAGCTCGGCTACGACATCGAT
ATCTTCGTGCATCACGGCGCCGGCGCCTATATCTGCGGCGAGGAAACCGCGCTGCTCGAGAGCCTTGAAGGCAAGAAAGG
CCAGCCGCGCCTGAAGCCGCCTTTCCCCGCGAATATGGGCCTTTACGGCTGCCCGACGACTGTCAACAACGTCGAGTCGA
TCGCGGTTACGCCGACCATCCTGCGCCGGGGCGCCGGCTGGTATACGAGCTTCGGCCGCCCGAACAATCACGGCACCAAG
CTCTATTCGGTTTCCGGACACGTCAATCGCCCGTGCACGGTCGAGGATGCGATGTCCATCCCCTTCCATGAGCTTATCGA
GAAGCACTGCGGCGGCATTCGCGGCGGCTGGGACAATCTGCTTGCCGTCATTCCCGGCGGCTCTTCGGTCCCCTGCGTGC
CCGGCGCGCAGATGAAGGACGCGATCATGGATTATGACGGCCTGCGCGAGCTCGGATCGGGTCTCGGAACGGCTGCCGTC
ATCGTCATGGACAAGTCGACCGACATCATCAAGGCGATCTGGCGGCTTTCGGCTTTCTACAAGCATGAGAGCTGCGGTCA
GTGCACGCCCTGCCGCGAAGGCACCGGCTGGATGATGCGCGTGATGGAGCGCATGGTGCAGGGCCGTGCCCAGAAGCGCG
AGATCGATATGCTCTTCGACGTGACGAAACAGGTCGAAGGCCACACGATCTGCGCGCTGGGCGATGCGGCGGCCTGGCCG
ATCCAGGGCCTCATCAAGCATTTCCGCCCGGAAATGGAGAAGCGGATAGACGAATACACCCGCAACGCGACTTCGCAAGG
CGCGGTGCTGGAGGCAGCGGAGTAA

Upstream 100 bases:

>100_bases
CCACCGCGAAGAAAGCGGCGGCGAAGAACGTCAAGGTTGAGGGCGAAACGGTCGACAAGTCGAAGCCCGCGAAGAAGCCG
CGGTGAAGAGGTGATACCCC

Downstream 100 bases:

>100_bases
GAAGAATGGCTGGGGCACGCAAGGACGGACAGGATAGGGAAGCCGCAAGCGCGGCCGCTCCATTCGCATGGCCTCAGGGC
GTCGACCCGGCCGATCCGTT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLKDEDRIFTNIYGLMDKSLKGAMARGHWDGTKQFLEKGRDWIINEVKASGLRGRGGAGFPTGLKWSFMPKESDGRPHYL
VVNADESEPGTCKDRDIMRHDPHTLIEGCVIASFAMGAHAAYIYVRGEFIREREALQAAIDECYAYGLLGKNNKLGYDID
IFVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVTPTILRRGAGWYTSFGRPNNHGTK
LYSVSGHVNRPCTVEDAMSIPFHELIEKHCGGIRGGWDNLLAVIPGGSSVPCVPGAQMKDAIMDYDGLRELGSGLGTAAV
IVMDKSTDIIKAIWRLSAFYKHESCGQCTPCREGTGWMMRVMERMVQGRAQKREIDMLFDVTKQVEGHTICALGDAAAWP
IQGLIKHFRPEMEKRIDEYTRNATSQGAVLEAAE

Sequences:

>Translated_434_residues
MLKDEDRIFTNIYGLMDKSLKGAMARGHWDGTKQFLEKGRDWIINEVKASGLRGRGGAGFPTGLKWSFMPKESDGRPHYL
VVNADESEPGTCKDRDIMRHDPHTLIEGCVIASFAMGAHAAYIYVRGEFIREREALQAAIDECYAYGLLGKNNKLGYDID
IFVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVTPTILRRGAGWYTSFGRPNNHGTK
LYSVSGHVNRPCTVEDAMSIPFHELIEKHCGGIRGGWDNLLAVIPGGSSVPCVPGAQMKDAIMDYDGLRELGSGLGTAAV
IVMDKSTDIIKAIWRLSAFYKHESCGQCTPCREGTGWMMRVMERMVQGRAQKREIDMLFDVTKQVEGHTICALGDAAAWP
IQGLIKHFRPEMEKRIDEYTRNATSQGAVLEAAE
>Mature_434_residues
MLKDEDRIFTNIYGLMDKSLKGAMARGHWDGTKQFLEKGRDWIINEVKASGLRGRGGAGFPTGLKWSFMPKESDGRPHYL
VVNADESEPGTCKDRDIMRHDPHTLIEGCVIASFAMGAHAAYIYVRGEFIREREALQAAIDECYAYGLLGKNNKLGYDID
IFVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVTPTILRRGAGWYTSFGRPNNHGTK
LYSVSGHVNRPCTVEDAMSIPFHELIEKHCGGIRGGWDNLLAVIPGGSSVPCVPGAQMKDAIMDYDGLRELGSGLGTAAV
IVMDKSTDIIKAIWRLSAFYKHESCGQCTPCREGTGWMMRVMERMVQGRAQKREIDMLFDVTKQVEGHTICALGDAAAWP
IQGLIKHFRPEMEKRIDEYTRNATSQGAVLEAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=67.7804295942721, Blast_Score=612, Evalue=1e-175,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=67.7804295942721, Blast_Score=612, Evalue=1e-175,
Organism=Escherichia coli, GI1788620, Length=384, Percent_Identity=43.4895833333333, Blast_Score=318, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17531727, Length=429, Percent_Identity=66.8997668997669, Blast_Score=613, Evalue=1e-176,
Organism=Drosophila melanogaster, GI19920794, Length=425, Percent_Identity=68.4705882352941, Blast_Score=630, Evalue=0.0,
Organism=Drosophila melanogaster, GI45550452, Length=432, Percent_Identity=64.3518518518518, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24653819, Length=425, Percent_Identity=45.8823529411765, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24653817, Length=425, Percent_Identity=42.3529411764706, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47847; Mature: 47847

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDEDRIFTNIYGLMDKSLKGAMARGHWDGTKQFLEKGRDWIINEVKASGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESDGRPHYLVVNADESEPGTCKDRDIMRHDPHTLIEGCVIASFAMGAHA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEFIREREALQAAIDECYAYGLLGKNNKLGYDIDIFVHHGAGAYICGEETALLE
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVTPTILRRGAGWYTSFGRPNNHGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHEEECHHHHHCCCCCCCCCCCCCCCCCE
LYSVSGHVNRPCTVEDAMSIPFHELIEKHCGGIRGGWDNLLAVIPGGSSVPCVPGAQMKD
EEEECCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCHHHH
AIMDYDGLRELGSGLGTAAVIVMDKSTDIIKAIWRLSAFYKHESCGQCTPCREGTGWMMR
HHHCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
VMERMVQGRAQKREIDMLFDVTKQVEGHTICALGDAAAWPIQGLIKHFRPEMEKRIDEYT
HHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
RNATSQGAVLEAAE
HCCCCCCCEEECCC
>Mature Secondary Structure
MLKDEDRIFTNIYGLMDKSLKGAMARGHWDGTKQFLEKGRDWIINEVKASGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESDGRPHYLVVNADESEPGTCKDRDIMRHDPHTLIEGCVIASFAMGAHA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEFIREREALQAAIDECYAYGLLGKNNKLGYDIDIFVHHGAGAYICGEETALLE
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVTPTILRRGAGWYTSFGRPNNHGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHEEECHHHHHCCCCCCCCCCCCCCCCCE
LYSVSGHVNRPCTVEDAMSIPFHELIEKHCGGIRGGWDNLLAVIPGGSSVPCVPGAQMKD
EEEECCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCHHHH
AIMDYDGLRELGSGLGTAAVIVMDKSTDIIKAIWRLSAFYKHESCGQCTPCREGTGWMMR
HHHCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
VMERMVQGRAQKREIDMLFDVTKQVEGHTICALGDAAAWPIQGLIKHFRPEMEKRIDEYT
HHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
RNATSQGAVLEAAE
HCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]