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The map label for this gene is cysS [H]

Identifier: 150395937

GI number: 150395937

Start: 765466

End: 766866

Strand: Direct

Name: cysS [H]

Synonym: Smed_0713

Alternate gene names: 150395937

Gene position: 765466-766866 (Clockwise)

Preceding gene: 150395935

Following gene: 150395938

Centisome position: 20.24

GC content: 62.03

Gene sequence:

>1401_bases
ATGGGCGGAATGACGGTTTTGAAGCTGTACAACACGCTGACGCGGGAAAAGACCGATTTCAGGCCGATCGATCCGAAAAA
CGTCCGCATGTATGTCTGCGGCCCGACGGTCTACGACTTTGCCCATATCGGCAATGCCCGGCCGATCATCGTCTTCGACG
TCCTCTTCCGGCTGCTGCGGCACGTCTACGGCACGGATCATGTCACCTATGCGCGCAACATCACCGACGTGGATGACAAG
ATAAATGCGCGGGCACTGCGCGACTATCCCGGCCTGCCGCTGAACGAGGCTATCCGGCATGTGACTGAGAGGACCGAGAC
GCGATTCCTCGAGGATGCCGCATTGCTCGGCTGCCTCGATCCCACAGTGCAGCCTCGCGCCACCGAGAACATCCCGGGGA
TGATCGAGATTATCGAAACGCTCATCGCCAAGGGCCATGCTTATGAGGCTGAGGGCGAGGTACTCTTCGACACGCGGTCG
ATGGCGGAATACGGGCAGCTTTCCAAACGCAATCTCGACGAGCAGCAGGCGGGTGCCCGTGTTGCCGTCGAGGCGCACAA
GAGAAACCCGGGCGATTTCGTGCTCTGGAAACTATCCGCCGGGCACGAGCCGGGATGGGAGAGCCCCTGGGGTCGCGGGC
GGCCCGGTTGGCACATCGAATGCTCCGCTATGAGCGGGCGCTATCTCGGCGAAGTCTTCGACATTCACGGCGGCGGCATC
GACCTGATCTTCCCGCATCACGAAAACGAGATCGCCCAGTCGCGGTGCGCCCACGGAACCGCGGTGATGGCGAATGTCTG
GATGCACAATGGCTTCCTGCAGGTCGAGGGCCGCAAGATGTCGAAGTCCGAAGGCAACTTCATCACCATCTACGACCTTC
TTCACACCGAAAAGTTCGGCGGCCGCAAATGGCCGGGCGAGGTGCTCCGGTTGGCGATGCTGATGACCCATTATAGGGAG
CCGATCGACTTCTCGATCAAGCGGCTGGAGGAGGCCGAGCATCTGCTGTCGAAATGGCCGGTTCACGGGTCCGCCTCGGG
CGAGGCGGACCCGGCTGTCGTGGCCGCGCTCACCGATGATCTCAATACCGTGGCCGCAATACAGGCTCTGCATGCTCTGG
CGCAAAAGGCCACTGCCGATGCCCGCCATCTGGGCGCCTTCGCCGCCAGCGCGGCCCTTCTCGGCGTGGAGCCGAAGGAG
ATCGAGCTCGACGAGGCGGTCGTGCAGGAGATCGACGGCCGCGTCCGTGAACGCCTGGAACTCCTGAAGAGCAAGAATTA
CGCGGAGGCCGACGGCATTCGCGCCGATCTCCTCGCAAGGGGAATTCAGCTCAAGGACGGCAAGGATCCTGAGACTGGCG
AACGGGTAACGACCTGGGAGGTGAAACGGTCTCAGGTCTAG

Upstream 100 bases:

>100_bases
GCTGGCCTGGCCGTTTTCGTCTCCAGAAATCCAAGATGACAACGCGCGGGGCCACCCGGGCAGGGCTATTCTGATTGCAT
GCAGACTTGGAGAATTTGGG

Downstream 100 bases:

>100_bases
GCACGTCGGGTAGAGCGGCAAGGGAGAGGAAGCGATATGGCTGACGAAATTCATGCGGGCGGGTGCCAGTGTGGCGCGGT
CCGCTTCCGTGTCGAGGGCA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGGMTVLKLYNTLTREKTDFRPIDPKNVRMYVCGPTVYDFAHIGNARPIIVFDVLFRLLRHVYGTDHVTYARNITDVDDK
INARALRDYPGLPLNEAIRHVTERTETRFLEDAALLGCLDPTVQPRATENIPGMIEIIETLIAKGHAYEAEGEVLFDTRS
MAEYGQLSKRNLDEQQAGARVAVEAHKRNPGDFVLWKLSAGHEPGWESPWGRGRPGWHIECSAMSGRYLGEVFDIHGGGI
DLIFPHHENEIAQSRCAHGTAVMANVWMHNGFLQVEGRKMSKSEGNFITIYDLLHTEKFGGRKWPGEVLRLAMLMTHYRE
PIDFSIKRLEEAEHLLSKWPVHGSASGEADPAVVAALTDDLNTVAAIQALHALAQKATADARHLGAFAASAALLGVEPKE
IELDEAVVQEIDGRVRERLELLKSKNYAEADGIRADLLARGIQLKDGKDPETGERVTTWEVKRSQV

Sequences:

>Translated_466_residues
MGGMTVLKLYNTLTREKTDFRPIDPKNVRMYVCGPTVYDFAHIGNARPIIVFDVLFRLLRHVYGTDHVTYARNITDVDDK
INARALRDYPGLPLNEAIRHVTERTETRFLEDAALLGCLDPTVQPRATENIPGMIEIIETLIAKGHAYEAEGEVLFDTRS
MAEYGQLSKRNLDEQQAGARVAVEAHKRNPGDFVLWKLSAGHEPGWESPWGRGRPGWHIECSAMSGRYLGEVFDIHGGGI
DLIFPHHENEIAQSRCAHGTAVMANVWMHNGFLQVEGRKMSKSEGNFITIYDLLHTEKFGGRKWPGEVLRLAMLMTHYRE
PIDFSIKRLEEAEHLLSKWPVHGSASGEADPAVVAALTDDLNTVAAIQALHALAQKATADARHLGAFAASAALLGVEPKE
IELDEAVVQEIDGRVRERLELLKSKNYAEADGIRADLLARGIQLKDGKDPETGERVTTWEVKRSQV
>Mature_465_residues
GGMTVLKLYNTLTREKTDFRPIDPKNVRMYVCGPTVYDFAHIGNARPIIVFDVLFRLLRHVYGTDHVTYARNITDVDDKI
NARALRDYPGLPLNEAIRHVTERTETRFLEDAALLGCLDPTVQPRATENIPGMIEIIETLIAKGHAYEAEGEVLFDTRSM
AEYGQLSKRNLDEQQAGARVAVEAHKRNPGDFVLWKLSAGHEPGWESPWGRGRPGWHIECSAMSGRYLGEVFDIHGGGID
LIFPHHENEIAQSRCAHGTAVMANVWMHNGFLQVEGRKMSKSEGNFITIYDLLHTEKFGGRKWPGEVLRLAMLMTHYREP
IDFSIKRLEEAEHLLSKWPVHGSASGEADPAVVAALTDDLNTVAAIQALHALAQKATADARHLGAFAASAALLGVEPKEI
ELDEAVVQEIDGRVRERLELLKSKNYAEADGIRADLLARGIQLKDGKDPETGERVTTWEVKRSQV

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI13375695, Length=530, Percent_Identity=33.7735849056604, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI62240992, Length=240, Percent_Identity=40.4166666666667, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI10835051, Length=240, Percent_Identity=40.4166666666667, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI21269877, Length=240, Percent_Identity=40.4166666666667, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI303304987, Length=240, Percent_Identity=40.4166666666667, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1786737, Length=483, Percent_Identity=43.6853002070393, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17509797, Length=246, Percent_Identity=40.2439024390244, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509795, Length=246, Percent_Identity=40.2439024390244, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324082, Length=343, Percent_Identity=33.8192419825073, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI19922218, Length=514, Percent_Identity=32.6848249027237, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI19922364, Length=311, Percent_Identity=35.048231511254, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF01406 tRNA-synt_1e [H]

EC number: =6.1.1.16 [H]

Molecular weight: Translated: 51993; Mature: 51862

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGMTVLKLYNTLTREKTDFRPIDPKNVRMYVCGPTVYDFAHIGNARPIIVFDVLFRLLR
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHH
HVYGTDHVTYARNITDVDDKINARALRDYPGLPLNEAIRHVTERTETRFLEDAALLGCLD
HHHCCCCEEEECCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PTVQPRATENIPGMIEIIETLIAKGHAYEAEGEVLFDTRSMAEYGQLSKRNLDEQQAGAR
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHCCCCHHHCCCE
VAVEAHKRNPGDFVLWKLSAGHEPGWESPWGRGRPGWHIECSAMSGRYLGEVFDIHGGGI
EEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHEEEECCCCE
DLIFPHHENEIAQSRCAHGTAVMANVWMHNGFLQVEGRKMSKSEGNFITIYDLLHTEKFG
EEEECCCCCHHHHHHHCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEEEHHHHHCC
GRKWPGEVLRLAMLMTHYREPIDFSIKRLEEAEHLLSKWPVHGSASGEADPAVVAALTDD
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHC
LNTVAAIQALHALAQKATADARHLGAFAASAALLGVEPKEIELDEAVVQEIDGRVRERLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLKSKNYAEADGIRADLLARGIQLKDGKDPETGERVTTWEVKRSQV
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
GGMTVLKLYNTLTREKTDFRPIDPKNVRMYVCGPTVYDFAHIGNARPIIVFDVLFRLLR
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHH
HVYGTDHVTYARNITDVDDKINARALRDYPGLPLNEAIRHVTERTETRFLEDAALLGCLD
HHHCCCCEEEECCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PTVQPRATENIPGMIEIIETLIAKGHAYEAEGEVLFDTRSMAEYGQLSKRNLDEQQAGAR
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHCCCCHHHCCCE
VAVEAHKRNPGDFVLWKLSAGHEPGWESPWGRGRPGWHIECSAMSGRYLGEVFDIHGGGI
EEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHEEEECCCCE
DLIFPHHENEIAQSRCAHGTAVMANVWMHNGFLQVEGRKMSKSEGNFITIYDLLHTEKFG
EEEECCCCCHHHHHHHCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEEEHHHHHCC
GRKWPGEVLRLAMLMTHYREPIDFSIKRLEEAEHLLSKWPVHGSASGEADPAVVAALTDD
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHC
LNTVAAIQALHALAQKATADARHLGAFAASAALLGVEPKEIELDEAVVQEIDGRVRERLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLKSKNYAEADGIRADLLARGIQLKDGKDPETGERVTTWEVKRSQV
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]