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The map label for this gene is nadA [H]

Identifier: 150395923

GI number: 150395923

Start: 754451

End: 755530

Strand: Direct

Name: nadA [H]

Synonym: Smed_0699

Alternate gene names: 150395923

Gene position: 754451-755530 (Clockwise)

Preceding gene: 150395922

Following gene: 150395924

Centisome position: 19.95

GC content: 59.63

Gene sequence:

>1080_bases
ATGACCACTCTTAACCTTCGCAAGGATGCGGCGCCCGCTCCGGCCTTCGTGAGCGCTGCGGCACGCTTCGGCGTCATCGA
AAAACCCGATCTCGCCTTCACCCCGGCTGTCGCACGCGAGACCGAGCATCTCTACGAGAAGGTCAAGGACTTCATCCCCG
CATTCGAGTGGGCGGCCTATGCGCCCTATGTCCATGCGATCAACCGGCTGAAGAAGGAACGCAACGCGGTCATCCTCGCT
CACAATTACCAGACGCCGGATATTTTTCACTGCGTGGCGGACATCGTCGGCGATTCGCTCCAACTCGCGCGCGACGCCAC
TAAAGTGGACGCCGAGATCATCATTCAGTGCGGCGTGCACTTCATGGCCGAGACGTCGAAGCTGCTCAACCCGGAAAAAA
CGGTCCTCATTCCGGATGCCAGAGCAGGGTGCTCGCTGTCGGAGTCGATCACCGGCGCGGATGTGCGGCTCCTCAAGGAG
CGCTATCCGGGTGTGCCGGTCGTTACCTATGTCAACACATCGGCCGATGTGAAGGCGGAGACCGACATCTGCTGCACCTC
GTCCAACGTGCTGGCAGTGGTTGAAAGTCTGGAATCCGATACCGTGCTCTGCATCCCCGACGAATATCTGGCGATGAACG
TGGCGCGAGAGACGAACAAGAAGATCCTGACCTGGAAAGGTCACTGCGAGGTTCACGAGCGTTTCACGGCAGCCGAACTC
CTGGCTTACAAGGAAGCCAATCCCGGCATCGAGATCGTCGGCCATCCGGAATGCCACCCCGACGTCATCGCCGTCTGCGA
CTTCTCCGGATCCACCTCGGGCATGATCAATTACGTCAAGGACAAACGGCCTCAACGCGTGCTGCTCGTGACCGAATGCT
CGATGGCATCGAATATTCAGGCGGAGGTCAAAGGCGTGGATTTCGTAAAGCCCTGCAATCTGTGTCCGCACATGAAGCGC
ATCACGCTGCCGAAGATCTTCGACAGCCTGCTCACCATGACGGAAGAGGTTCTGGTCGACCCCGCGATCGCCGACCGCGC
GCGGCTCGCAGTCGAGCGCATGGTGAACCTCAAGCAGTGA

Upstream 100 bases:

>100_bases
TTCTAAATCAGTCACGGCGGCTTAGCCGCTTTTGTTTTGCACCAATTATGCTCAATGTGAGCATAATTGTATCACCGGCA
CGGTGAGAGAGGAGATCCCG

Downstream 100 bases:

>100_bases
TCGTTCGGCCGGAGTCGTTCCGGCAGGCATGCCGAGGCATGCAGGGTTCAAATACTGCGGCAGATTTGCGTGTCAGAGAG
GACGCGCGGCGCCGCAGGTC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTTLNLRKDAAPAPAFVSAAARFGVIEKPDLAFTPAVARETEHLYEKVKDFIPAFEWAAYAPYVHAINRLKKERNAVILA
HNYQTPDIFHCVADIVGDSLQLARDATKVDAEIIIQCGVHFMAETSKLLNPEKTVLIPDARAGCSLSESITGADVRLLKE
RYPGVPVVTYVNTSADVKAETDICCTSSNVLAVVESLESDTVLCIPDEYLAMNVARETNKKILTWKGHCEVHERFTAAEL
LAYKEANPGIEIVGHPECHPDVIAVCDFSGSTSGMINYVKDKRPQRVLLVTECSMASNIQAEVKGVDFVKPCNLCPHMKR
ITLPKIFDSLLTMTEEVLVDPAIADRARLAVERMVNLKQ

Sequences:

>Translated_359_residues
MTTLNLRKDAAPAPAFVSAAARFGVIEKPDLAFTPAVARETEHLYEKVKDFIPAFEWAAYAPYVHAINRLKKERNAVILA
HNYQTPDIFHCVADIVGDSLQLARDATKVDAEIIIQCGVHFMAETSKLLNPEKTVLIPDARAGCSLSESITGADVRLLKE
RYPGVPVVTYVNTSADVKAETDICCTSSNVLAVVESLESDTVLCIPDEYLAMNVARETNKKILTWKGHCEVHERFTAAEL
LAYKEANPGIEIVGHPECHPDVIAVCDFSGSTSGMINYVKDKRPQRVLLVTECSMASNIQAEVKGVDFVKPCNLCPHMKR
ITLPKIFDSLLTMTEEVLVDPAIADRARLAVERMVNLKQ
>Mature_358_residues
TTLNLRKDAAPAPAFVSAAARFGVIEKPDLAFTPAVARETEHLYEKVKDFIPAFEWAAYAPYVHAINRLKKERNAVILAH
NYQTPDIFHCVADIVGDSLQLARDATKVDAEIIIQCGVHFMAETSKLLNPEKTVLIPDARAGCSLSESITGADVRLLKER
YPGVPVVTYVNTSADVKAETDICCTSSNVLAVVESLESDTVLCIPDEYLAMNVARETNKKILTWKGHCEVHERFTAAELL
AYKEANPGIEIVGHPECHPDVIAVCDFSGSTSGMINYVKDKRPQRVLLVTECSMASNIQAEVKGVDFVKPCNLCPHMKRI
TLPKIFDSLLTMTEEVLVDPAIADRARLAVERMVNLKQ

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=315, Percent_Identity=33.6507936507937, Blast_Score=162, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 39580; Mature: 39449

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLNLRKDAAPAPAFVSAAARFGVIEKPDLAFTPAVARETEHLYEKVKDFIPAFEWAAY
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
APYVHAINRLKKERNAVILAHNYQTPDIFHCVADIVGDSLQLARDATKVDAEIIIQCGVH
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHH
FMAETSKLLNPEKTVLIPDARAGCSLSESITGADVRLLKERYPGVPVVTYVNTSADVKAE
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEC
TDICCTSSNVLAVVESLESDTVLCIPDEYLAMNVARETNKKILTWKGHCEVHERFTAAEL
CCEEECCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHH
LAYKEANPGIEIVGHPECHPDVIAVCDFSGSTSGMINYVKDKRPQRVLLVTECSMASNIQ
HHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCH
AEVKGVDFVKPCNLCPHMKRITLPKIFDSLLTMTEEVLVDPAIADRARLAVERMVNLKQ
HHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTLNLRKDAAPAPAFVSAAARFGVIEKPDLAFTPAVARETEHLYEKVKDFIPAFEWAAY
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
APYVHAINRLKKERNAVILAHNYQTPDIFHCVADIVGDSLQLARDATKVDAEIIIQCGVH
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHH
FMAETSKLLNPEKTVLIPDARAGCSLSESITGADVRLLKERYPGVPVVTYVNTSADVKAE
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEC
TDICCTSSNVLAVVESLESDTVLCIPDEYLAMNVARETNKKILTWKGHCEVHERFTAAEL
CCEEECCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHH
LAYKEANPGIEIVGHPECHPDVIAVCDFSGSTSGMINYVKDKRPQRVLLVTECSMASNIQ
HHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCH
AEVKGVDFVKPCNLCPHMKRITLPKIFDSLLTMTEEVLVDPAIADRARLAVERMVNLKQ
HHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]