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The map label for this gene is era [H]

Identifier: 150395907

GI number: 150395907

Start: 734298

End: 735230

Strand: Direct

Name: era [H]

Synonym: Smed_0683

Alternate gene names: 150395907

Gene position: 734298-735230 (Clockwise)

Preceding gene: 150395906

Following gene: 150395909

Centisome position: 19.42

GC content: 61.63

Gene sequence:

>933_bases
ATGACGACGGACAATCAACAGGATACGGCCGCTGCTGCGGTGCCGACGCGCTCTGGCTTCGTGGCGCTGATCGGGGCGAC
GAATGCCGGAAAGTCGACATTGATCAATCGCCTTGTCGGCGCAAAAGTGTCGATCGTCAGCCACAAGGTACAGACGACGC
GGGCGATCGTTCGCGGCATCGCGATCCACGACAATGCGCAGATCGTATTCATGGACACGCCCGGCATCTTCAAGCCACGG
CGCCGGCTCGACCGCGCCATGGTCACGACGGCTTGGGGCGGAGCCAAGGATGCCGATCTGATCATGTTGCTGATCGACAG
CGAGCGCGGGATCAAGGGTGATGCCGACACGATCCTGGAGGGCCTCAAGGATGTGCACCAGCCAAAGGTGCTCGTCCTCA
ACAAGGTCGATCAGGTTCGCCGAGAGGATTTGCTGAAGCTCGCAGCCGCTGCGAACGAGGTGGTGGCATTCGAGCGCACC
TTCATGATCTCCGCCCTGACCGGTTCCGGCTGCGAAGACGTGATGGATTATCTCGCCGAGAGGCTTCCGGAGGGCCCCTG
GTATTACCCGGAGGACCAGATTTCCGATCTGCCGATGCGGCAGCTTGCTGCCGAGATCACGCGCGAGAAGCTCTTCCTTC
GGCTGCACCAGGAGCTTCCCTATGCATCTCACGTCGAGACGGAGAAGTGGGAAGAGCGCAAGGACGGTTCCGTGCGCATC
GAGCAGGTGATCTATGTGGAGCGCGATAGCCAGAAGAAGATCGCACTCGGCAAGGGCGGCGAGGCGATCAAGGCGATCTC
GACCGCCGCGCGCAAGGAGATCTCCGAGATCCTCGAGCAGCCCGTGCACCTCTTCCTGTTCGTGAAGGTGCGCGAGAACT
GGGGCGACGATCCCGAGCGCTTCCGCGAGATGGGGCTCGATTTTCCGAAGTAG

Upstream 100 bases:

>100_bases
TTGATCGTTCCAAGCGCGGGGCCGAGCAGGTCGCGGCCATGAAATTGTTAGAACGCGAAGGTGTTTGGCAGAAACGCTCT
GCCGGAAATTGACGGATGTG

Downstream 100 bases:

>100_bases
CCTACTGCATATTTCCTTTAATCGGATCCGATTAAAGGACAACAACATGCAGCAGATCAAAGTGCTACAGCGACCTTTGT
GCGTCTGATGAGACGCGCGG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTTDNQQDTAAAAVPTRSGFVALIGATNAGKSTLINRLVGAKVSIVSHKVQTTRAIVRGIAIHDNAQIVFMDTPGIFKPR
RRLDRAMVTTAWGGAKDADLIMLLIDSERGIKGDADTILEGLKDVHQPKVLVLNKVDQVRREDLLKLAAAANEVVAFERT
FMISALTGSGCEDVMDYLAERLPEGPWYYPEDQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSVRI
EQVIYVERDSQKKIALGKGGEAIKAISTAARKEISEILEQPVHLFLFVKVRENWGDDPERFREMGLDFPK

Sequences:

>Translated_310_residues
MTTDNQQDTAAAAVPTRSGFVALIGATNAGKSTLINRLVGAKVSIVSHKVQTTRAIVRGIAIHDNAQIVFMDTPGIFKPR
RRLDRAMVTTAWGGAKDADLIMLLIDSERGIKGDADTILEGLKDVHQPKVLVLNKVDQVRREDLLKLAAAANEVVAFERT
FMISALTGSGCEDVMDYLAERLPEGPWYYPEDQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSVRI
EQVIYVERDSQKKIALGKGGEAIKAISTAARKEISEILEQPVHLFLFVKVRENWGDDPERFREMGLDFPK
>Mature_309_residues
TTDNQQDTAAAAVPTRSGFVALIGATNAGKSTLINRLVGAKVSIVSHKVQTTRAIVRGIAIHDNAQIVFMDTPGIFKPRR
RLDRAMVTTAWGGAKDADLIMLLIDSERGIKGDADTILEGLKDVHQPKVLVLNKVDQVRREDLLKLAAAANEVVAFERTF
MISALTGSGCEDVMDYLAERLPEGPWYYPEDQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSVRIE
QVIYVERDSQKKIALGKGGEAIKAISTAARKEISEILEQPVHLFLFVKVRENWGDDPERFREMGLDFPK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=320, Percent_Identity=30.625, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=38.013698630137, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI87082120, Length=166, Percent_Identity=28.9156626506024, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646434, Length=310, Percent_Identity=29.0322580645161, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34676; Mature: 34545

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDNQQDTAAAAVPTRSGFVALIGATNAGKSTLINRLVGAKVSIVSHKVQTTRAIVRGI
CCCCCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AIHDNAQIVFMDTPGIFKPRRRLDRAMVTTAWGGAKDADLIMLLIDSERGIKGDADTILE
EEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
GLKDVHQPKVLVLNKVDQVRREDLLKLAAAANEVVAFERTFMISALTGSGCEDVMDYLAE
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
RLPEGPWYYPEDQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSVRI
HCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEE
EQVIYVERDSQKKIALGKGGEAIKAISTAARKEISEILEQPVHLFLFVKVRENWGDDPER
EEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHH
FREMGLDFPK
HHHCCCCCCC
>Mature Secondary Structure 
TTDNQQDTAAAAVPTRSGFVALIGATNAGKSTLINRLVGAKVSIVSHKVQTTRAIVRGI
CCCCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AIHDNAQIVFMDTPGIFKPRRRLDRAMVTTAWGGAKDADLIMLLIDSERGIKGDADTILE
EEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
GLKDVHQPKVLVLNKVDQVRREDLLKLAAAANEVVAFERTFMISALTGSGCEDVMDYLAE
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
RLPEGPWYYPEDQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSVRI
HCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEE
EQVIYVERDSQKKIALGKGGEAIKAISTAARKEISEILEQPVHLFLFVKVRENWGDDPER
EEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHH
FREMGLDFPK
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]