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The map label for this gene is rnc [H]

Identifier: 150395906

GI number: 150395906

Start: 733573

End: 734289

Strand: Direct

Name: rnc [H]

Synonym: Smed_0682

Alternate gene names: 150395906

Gene position: 733573-734289 (Clockwise)

Preceding gene: 150395905

Following gene: 150395907

Centisome position: 19.4

GC content: 60.95

Gene sequence:

>717_bases
ATGAAGGGTCGCTCGTTGAACGCGGAGGACCGGGCGCGGCTTGAGGCTGCGATCGGTTACCAGTTCGCCGAGAAGGAACG
TCTCGACCGGGCCCTGACACATTCGAGCGCGAGAAGCGGCCGTGCAATCAACTACCAGCGGCTCGAATTCCTTGGGGACA
GGATTCTTGGGCTCTGCGTCGCGGAGCTCCTGTTCCAGACATTCAGCGATGCAAACGAAGGCGAGCTCTCGGTTCGCCTG
AATCAGCTCGTCAGCGCGGAGAGTTGCGCGAAAGTGGCCGATGAGCTCTCATTGCATGAATTCATCCGCACTGGTTCGGA
TGTGAAGAAGATCACGGGCAAGCACATGATGAATGTGCGTGCCGATGTGGTAGAGTCGCTGATTGCCGCCATCTATCTCG
ATGGCGGCCTGGAGGCGGCGCGGCGCTTCGTGCTCGAGCATTGGACGCATCGCGCTGCAAGTGCGGACGGCGCCAGGCGC
GACGCCAAGACGGAACTGCAGGAATGGGCGCATGCCAGGTTCGGTGTGGCGCCGAAGTACCGAACTGAAGATCGCTCCGG
CCCGGATCACGATCCGCGCTTTACCGTCACGGTAGAGGTCGACGGAATCGACCCGGAGACCGGGGTTGATCGTTCCAAGC
GCGGGGCCGAGCAGGTCGCGGCCATGAAATTGTTAGAACGCGAAGGTGTTTGGCAGAAACGCTCTGCCGGAAATTGA

Upstream 100 bases:

>100_bases
GCCTGATTTTCTTCTCGCTCGGTAACGACACCTCGTTCCGGCAGATCTGGAAATGGCCTGCGAACCTGCGTTACGACCGT
CTGTTCAAGGTCGTCAACTG

Downstream 100 bases:

>100_bases
CGGATGTGATGACGACGGACAATCAACAGGATACGGCCGCTGCTGCGGTGCCGACGCGCTCTGGCTTCGTGGCGCTGATC
GGGGCGACGAATGCCGGAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKGRSLNAEDRARLEAAIGYQFAEKERLDRALTHSSARSGRAINYQRLEFLGDRILGLCVAELLFQTFSDANEGELSVRL
NQLVSAESCAKVADELSLHEFIRTGSDVKKITGKHMMNVRADVVESLIAAIYLDGGLEAARRFVLEHWTHRAASADGARR
DAKTELQEWAHARFGVAPKYRTEDRSGPDHDPRFTVTVEVDGIDPETGVDRSKRGAEQVAAMKLLEREGVWQKRSAGN

Sequences:

>Translated_238_residues
MKGRSLNAEDRARLEAAIGYQFAEKERLDRALTHSSARSGRAINYQRLEFLGDRILGLCVAELLFQTFSDANEGELSVRL
NQLVSAESCAKVADELSLHEFIRTGSDVKKITGKHMMNVRADVVESLIAAIYLDGGLEAARRFVLEHWTHRAASADGARR
DAKTELQEWAHARFGVAPKYRTEDRSGPDHDPRFTVTVEVDGIDPETGVDRSKRGAEQVAAMKLLEREGVWQKRSAGN
>Mature_238_residues
MKGRSLNAEDRARLEAAIGYQFAEKERLDRALTHSSARSGRAINYQRLEFLGDRILGLCVAELLFQTFSDANEGELSVRL
NQLVSAESCAKVADELSLHEFIRTGSDVKKITGKHMMNVRADVVESLIAAIYLDGGLEAARRFVLEHWTHRAASADGARR
DAKTELQEWAHARFGVAPKYRTEDRSGPDHDPRFTVTVEVDGIDPETGVDRSKRGAEQVAAMKLLEREGVWQKRSAGN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=32.7354260089686, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=32.7354260089686, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=34.6341463414634, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17506883, Length=237, Percent_Identity=29.535864978903, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202651, Length=237, Percent_Identity=29.535864978903, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=27.6315789473684, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26522; Mature: 26522

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRSLNAEDRARLEAAIGYQFAEKERLDRALTHSSARSGRAINYQRLEFLGDRILGLCV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AELLFQTFSDANEGELSVRLNQLVSAESCAKVADELSLHEFIRTGSDVKKITGKHMMNVR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADVVESLIAAIYLDGGLEAARRFVLEHWTHRAASADGARRDAKTELQEWAHARFGVAPKY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
RTEDRSGPDHDPRFTVTVEVDGIDPETGVDRSKRGAEQVAAMKLLEREGVWQKRSAGN
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKGRSLNAEDRARLEAAIGYQFAEKERLDRALTHSSARSGRAINYQRLEFLGDRILGLCV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AELLFQTFSDANEGELSVRLNQLVSAESCAKVADELSLHEFIRTGSDVKKITGKHMMNVR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADVVESLIAAIYLDGGLEAARRFVLEHWTHRAASADGARRDAKTELQEWAHARFGVAPKY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
RTEDRSGPDHDPRFTVTVEVDGIDPETGVDRSKRGAEQVAAMKLLEREGVWQKRSAGN
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA