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The map label for this gene is lepB [H]

Identifier: 150395905

GI number: 150395905

Start: 732830

End: 733573

Strand: Direct

Name: lepB [H]

Synonym: Smed_0681

Alternate gene names: 150395905

Gene position: 732830-733573 (Clockwise)

Preceding gene: 150395904

Following gene: 150395906

Centisome position: 19.38

GC content: 58.2

Gene sequence:

>744_bases
GTGGCAGAAAAGACAGAAGCGAAGCAGAGCGGTCTCTGGGAGAACGTCAAGGTCATCGTCCAGGCGCTGCTCCTGGCCGT
GGTCATCCGCACAGTCTTCTTTCAGCCCTTCACGATCCCTTCCGGCTCGATGATGCCGACGCTCCTCGTCGGCGATTACA
TCTTCGTCAACAAGTTCGCCTATGGCTATTCGAAATACTCGCTGCCATTCTCGCCGAATCTTTTCAGCGGCCGAATTTTC
GCAAGCGAACCGGAGCGGGGCGACATCGTCGTCTTCCGGTTCCCGCCCAACCCGGACATCGACTACATCAAGCGTCTCGT
CGGCCTGCCGGGCGATCGCCTCCAGGTCAGGAACAGCATTCTCTACGTCAATGACAAGGCGGTCGAACGGGTACCGGCCG
GCCCCTTCCGGGCCGATGATCAGTACGACACAGGTGGCGATGTGCCCGTCTATCGCGAGACGATGGACAACGGCATGACT
TACGAAACACTCGACCAGTTCCCGGATTCACGCGGCGATAACACCCGTGAGTTCATCGTTCCCGAAGGCCATTATTTCAT
GATGGGCGATAACAGGGACAACTCGGCCGACAGCCGTTTCGACGTTGGCTTCGTGCCGGCTGAAAACCTGGTTGGCCGCG
CCAGCCTGATTTTCTTCTCGCTCGGTAACGACACCTCGTTCCGGCAGATCTGGAAATGGCCTGCGAACCTGCGTTACGAC
CGTCTGTTCAAGGTCGTCAACTGA

Upstream 100 bases:

>100_bases
CATCGAGTTGCGGGGAGACGTGCGGCATGAGTTCGGGCGCAAACGAAAGTTGAAGCGTTAGGCTCGGGTGCCCCGGGCAG
GATGACAAGGAAGACTGAGC

Downstream 100 bases:

>100_bases
TGAAGGGTCGCTCGTTGAACGCGGAGGACCGGGCGCGGCTTGAGGCTGCGATCGGTTACCAGTTCGCCGAGAAGGAACGT
CTCGACCGGGCCCTGACACA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MAEKTEAKQSGLWENVKVIVQALLLAVVIRTVFFQPFTIPSGSMMPTLLVGDYIFVNKFAYGYSKYSLPFSPNLFSGRIF
ASEPERGDIVVFRFPPNPDIDYIKRLVGLPGDRLQVRNSILYVNDKAVERVPAGPFRADDQYDTGGDVPVYRETMDNGMT
YETLDQFPDSRGDNTREFIVPEGHYFMMGDNRDNSADSRFDVGFVPAENLVGRASLIFFSLGNDTSFRQIWKWPANLRYD
RLFKVVN

Sequences:

>Translated_247_residues
MAEKTEAKQSGLWENVKVIVQALLLAVVIRTVFFQPFTIPSGSMMPTLLVGDYIFVNKFAYGYSKYSLPFSPNLFSGRIF
ASEPERGDIVVFRFPPNPDIDYIKRLVGLPGDRLQVRNSILYVNDKAVERVPAGPFRADDQYDTGGDVPVYRETMDNGMT
YETLDQFPDSRGDNTREFIVPEGHYFMMGDNRDNSADSRFDVGFVPAENLVGRASLIFFSLGNDTSFRQIWKWPANLRYD
RLFKVVN
>Mature_246_residues
AEKTEAKQSGLWENVKVIVQALLLAVVIRTVFFQPFTIPSGSMMPTLLVGDYIFVNKFAYGYSKYSLPFSPNLFSGRIFA
SEPERGDIVVFRFPPNPDIDYIKRLVGLPGDRLQVRNSILYVNDKAVERVPAGPFRADDQYDTGGDVPVYRETMDNGMTY
ETLDQFPDSRGDNTREFIVPEGHYFMMGDNRDNSADSRFDVGFVPAENLVGRASLIFFSLGNDTSFRQIWKWPANLRYDR
LFKVVN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=283, Percent_Identity=35.6890459363958, Blast_Score=149, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 28146; Mature: 28015

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKTEAKQSGLWENVKVIVQALLLAVVIRTVFFQPFTIPSGSMMPTLLVGDYIFVNKFA
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEHHHH
YGYSKYSLPFSPNLFSGRIFASEPERGDIVVFRFPPNPDIDYIKRLVGLPGDRLQVRNSI
HCCEEECCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEECCE
LYVNDKAVERVPAGPFRADDQYDTGGDVPVYRETMDNGMTYETLDQFPDSRGDNTREFIV
EEECCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEE
PEGHYFMMGDNRDNSADSRFDVGFVPAENLVGRASLIFFSLGNDTSFRQIWKWPANLRYD
CCCCEEEEECCCCCCCCCCEEEEECCHHHHCCCEEEEEEECCCCCCHHHHHCCCCCCCHH
RLFKVVN
HHHHCCC
>Mature Secondary Structure 
AEKTEAKQSGLWENVKVIVQALLLAVVIRTVFFQPFTIPSGSMMPTLLVGDYIFVNKFA
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEHHHH
YGYSKYSLPFSPNLFSGRIFASEPERGDIVVFRFPPNPDIDYIKRLVGLPGDRLQVRNSI
HCCEEECCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEECCE
LYVNDKAVERVPAGPFRADDQYDTGGDVPVYRETMDNGMTYETLDQFPDSRGDNTREFIV
EEECCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEE
PEGHYFMMGDNRDNSADSRFDVGFVPAENLVGRASLIFFSLGNDTSFRQIWKWPANLRYD
CCCCEEEEECCCCCCCCCCEEEEECCHHHHCCCEEEEEEECCCCCCHHHHHCCCCCCCHH
RLFKVVN
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]