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The map label for this gene is menA [H]

Identifier: 150008187

GI number: 150008187

Start: 1815864

End: 1816754

Strand: Reverse

Name: menA [H]

Synonym: BDI_1553

Alternate gene names: 150008187

Gene position: 1816754-1815864 (Counterclockwise)

Preceding gene: 150008190

Following gene: 150008184

Centisome position: 37.76

GC content: 45.34

Gene sequence:

>891_bases
ATGGAGAATAACAGATCGAGAATTCAAGCTTGGTTAGAGGCGGCACGTCCGAAAACGTTGCCGGCATCATTTAGTCCGGT
ATTAGTTGGGTGTGCGCTGGCTTACAGGGATGGAGTATTTAAATTGGCTCCGGCGATCCTTTGTGTTTTGGTGGCTTTAC
TTGCCCAGATAGCCAGTAATTTTGCCAATGATTATTTTGATTTTAAGAAGGGGGCGGATAAGGAGGACCGGTTAGGCCCG
GAGCGAGCGGTGGCTTCCGGTTGGATAACTCCTAAGGCAATGCTATGGGGGACTTTTATCACGTTGGGGCTTTCTTGTCT
ATGTGGCTGTTTCTTGTTGTTCTTTGCCGGCTGGGAGCTCATCGGTGTAGGAATTGCTATTGCGATTTGTGTCTTGGCTT
ATTCAGCAGGGCCATTTCCTTTGGCTTATAACGGGCTGGGGGATGTGTGTGTCGTATTGTTTTATGGGATTATTCCGGTT
TGTTTTACGTATTATGTACAAGCATTATCGTTTTCCTTATTGTCATTCTTGCTTTCGTTGTCATTGGGGCTGTTGTCCGC
TAATATTTTGATCGTGAATAATTACCGGGATTATGAGCAAGATAAGGCGGCTCGTAAACGGACTACGATTGTGCTATTCG
GGCGTACGTTCGGGTTGGTAACTTATTTGCTGAACGGTATATTGGCTTTTTTGATCACGCTGCCTTTATTGATGGATGCC
TCACCTTGGCTTGTTTGTTTATTCGCGGCTTTTAGCGTGCTGTTTGCCGCCACATGGCTGGAGATGAAACAGTATCAAGG
CCGTGAGCTTAATAGAACTTTAGGGCATACGGCACGGAATGTATTTATCTATGCCGTGTTGCTTTCAGTTGTATTGTTAT
TTGGTTCTTAA

Upstream 100 bases:

>100_bases
TCTTCATGGCGCAAATATACAAGTATTTCTTTAGATAATAACAACAGTATATGTTATTTGTTTTTTATTTTTGTAGTTAT
TTTAAGAATAAAACAATAGA

Downstream 100 bases:

>100_bases
GATGTGCCGTGCTTTGAACAATCGCTTGGCCTCATGGAGATTTTTCTGTATGTATTTGGACAGGATAATCAATGTAACCG
CTACGATAATCAGTAAGATT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MENNRSRIQAWLEAARPKTLPASFSPVLVGCALAYRDGVFKLAPAILCVLVALLAQIASNFANDYFDFKKGADKEDRLGP
ERAVASGWITPKAMLWGTFITLGLSCLCGCFLLFFAGWELIGVGIAIAICVLAYSAGPFPLAYNGLGDVCVVLFYGIIPV
CFTYYVQALSFSLLSFLLSLSLGLLSANILIVNNYRDYEQDKAARKRTTIVLFGRTFGLVTYLLNGILAFLITLPLLMDA
SPWLVCLFAAFSVLFAATWLEMKQYQGRELNRTLGHTARNVFIYAVLLSVVLLFGS

Sequences:

>Translated_296_residues
MENNRSRIQAWLEAARPKTLPASFSPVLVGCALAYRDGVFKLAPAILCVLVALLAQIASNFANDYFDFKKGADKEDRLGP
ERAVASGWITPKAMLWGTFITLGLSCLCGCFLLFFAGWELIGVGIAIAICVLAYSAGPFPLAYNGLGDVCVVLFYGIIPV
CFTYYVQALSFSLLSFLLSLSLGLLSANILIVNNYRDYEQDKAARKRTTIVLFGRTFGLVTYLLNGILAFLITLPLLMDA
SPWLVCLFAAFSVLFAATWLEMKQYQGRELNRTLGHTARNVFIYAVLLSVVLLFGS
>Mature_296_residues
MENNRSRIQAWLEAARPKTLPASFSPVLVGCALAYRDGVFKLAPAILCVLVALLAQIASNFANDYFDFKKGADKEDRLGP
ERAVASGWITPKAMLWGTFITLGLSCLCGCFLLFFAGWELIGVGIAIAICVLAYSAGPFPLAYNGLGDVCVVLFYGIIPV
CFTYYVQALSFSLLSFLLSLSLGLLSANILIVNNYRDYEQDKAARKRTTIVLFGRTFGLVTYLLNGILAFLITLPLLMDA
SPWLVCLFAAFSVLFAATWLEMKQYQGRELNRTLGHTARNVFIYAVLLSVVLLFGS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=281, Percent_Identity=29.5373665480427, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1790365, Length=222, Percent_Identity=40.5405405405405, Blast_Score=151, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17737429, Length=226, Percent_Identity=29.646017699115, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32496; Mature: 32496

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNRSRIQAWLEAARPKTLPASFSPVLVGCALAYRDGVFKLAPAILCVLVALLAQIASN
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FANDYFDFKKGADKEDRLGPERAVASGWITPKAMLWGTFITLGLSCLCGCFLLFFAGWEL
HHHHHHHHHCCCCCHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVGIAIAICVLAYSAGPFPLAYNGLGDVCVVLFYGIIPVCFTYYVQALSFSLLSFLLSL
HHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLLSANILIVNNYRDYEQDKAARKRTTIVLFGRTFGLVTYLLNGILAFLITLPLLMDA
HHHHHHCCEEEEECCCCHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPWLVCLFAAFSVLFAATWLEMKQYQGRELNRTLGHTARNVFIYAVLLSVVLLFGS
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENNRSRIQAWLEAARPKTLPASFSPVLVGCALAYRDGVFKLAPAILCVLVALLAQIASN
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FANDYFDFKKGADKEDRLGPERAVASGWITPKAMLWGTFITLGLSCLCGCFLLFFAGWEL
HHHHHHHHHCCCCCHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVGIAIAICVLAYSAGPFPLAYNGLGDVCVVLFYGIIPVCFTYYVQALSFSLLSFLLSL
HHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLLSANILIVNNYRDYEQDKAARKRTTIVLFGRTFGLVTYLLNGILAFLITLPLLMDA
HHHHHHCCEEEEECCCCHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPWLVCLFAAFSVLFAATWLEMKQYQGRELNRTLGHTARNVFIYAVLLSVVLLFGS
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]