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The map label for this gene is fsr [H]

Identifier: 150008170

GI number: 150008170

Start: 1800680

End: 1801396

Strand: Reverse

Name: fsr [H]

Synonym: BDI_1536

Alternate gene names: 150008170

Gene position: 1801396-1800680 (Counterclockwise)

Preceding gene: 150008171

Following gene: 150008169

Centisome position: 37.44

GC content: 45.05

Gene sequence:

>717_bases
TTGGTGGCGCCTTATGGACGGACTCATATCGCTTTGTTTTCTATACTGGCATTCGTCGCTATTTTGGTGATGATTCCTAT
CTGCCGTTGGTATAAGGCGTATTTGAGTCGGGTGAAATGGCAGAAGAAGTCGGGTGAGACGCATGTGGAGATGCCTCTTT
CTTTGGGAAAAACAGTCTTTTCGATCTCGATATTGCTGACCTTGATTTTCTCTAAATATATCTATATGGCTAGTTTGAAT
AGCTACTATACCTTTTACTTGATCCATAAATTCGGGGTGAGTGTACAGACTTCGCAGATCTGTTTGTTCGTCTTCCTGAT
CGCTACGGCCATGGGAACCTTGGCGGGTGGTCCTATCGGTGATAAGATAGGACGGAAATATGTGATTTGGGGATCGATTC
TAGGGGCAGCCCCATTTAGCTTGTTGATGCCGCATGTGGGATTCGCTTGGACGATCGTGCTTAGTTTTTGCGTGGGTTTG
GTCTTATCATCGGCGTTCCCGGCTATTTTGTTGTATGCGCAAGAGTTGCTTCCTTATAAATTAGGTCTTATCTCGGGACT
TTTCTTTGGATTTGCTTTCGGTGTGGCGGGTATAGCCTCGGCCGTATTAGGAAATATGGCGGATCATTATGGAATAGAGG
CTGTCTACAACGTATGTGGCTTCATGCCTCTTTTAGGACTGGTTACTTGGTTCCTTCCCAACTTGAAAAAGAAGTAA

Upstream 100 bases:

>100_bases
TACCTCGCTAGCGTCGGGAGGGCGTAGGGGATTGGCACAATCGCTTTTTCAAGTGGGTGGTAATTAGGGCGGATCGTTAG
GTCCGCTACTGGTTGCTTTA

Downstream 100 bases:

>100_bases
AAACAATCCTCCCTTTTTCGCTGTTATTACTCCAACTGAACGTCAATTACTAAATGAGTTTATGGTGAGTAATATAGTAT
CTTACAGTATTCTTTTGCTG

Product: putative fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MVAPYGRTHIALFSILAFVAILVMIPICRWYKAYLSRVKWQKKSGETHVEMPLSLGKTVFSISILLTLIFSKYIYMASLN
SYYTFYLIHKFGVSVQTSQICLFVFLIATAMGTLAGGPIGDKIGRKYVIWGSILGAAPFSLLMPHVGFAWTIVLSFCVGL
VLSSAFPAILLYAQELLPYKLGLISGLFFGFAFGVAGIASAVLGNMADHYGIEAVYNVCGFMPLLGLVTWFLPNLKKK

Sequences:

>Translated_238_residues
MVAPYGRTHIALFSILAFVAILVMIPICRWYKAYLSRVKWQKKSGETHVEMPLSLGKTVFSISILLTLIFSKYIYMASLN
SYYTFYLIHKFGVSVQTSQICLFVFLIATAMGTLAGGPIGDKIGRKYVIWGSILGAAPFSLLMPHVGFAWTIVLSFCVGL
VLSSAFPAILLYAQELLPYKLGLISGLFFGFAFGVAGIASAVLGNMADHYGIEAVYNVCGFMPLLGLVTWFLPNLKKK
>Mature_238_residues
MVAPYGRTHIALFSILAFVAILVMIPICRWYKAYLSRVKWQKKSGETHVEMPLSLGKTVFSISILLTLIFSKYIYMASLN
SYYTFYLIHKFGVSVQTSQICLFVFLIATAMGTLAGGPIGDKIGRKYVIWGSILGAAPFSLLMPHVGFAWTIVLSFCVGL
VLSSAFPAILLYAQELLPYKLGLISGLFFGFAFGVAGIASAVLGNMADHYGIEAVYNVCGFMPLLGLVTWFLPNLKKK

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=238, Percent_Identity=55.4621848739496, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 26166; Mature: 26166

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPYGRTHIALFSILAFVAILVMIPICRWYKAYLSRVKWQKKSGETHVEMPLSLGKTVF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHH
SISILLTLIFSKYIYMASLNSYYTFYLIHKFGVSVQTSQICLFVFLIATAMGTLAGGPIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
DKIGRKYVIWGSILGAAPFSLLMPHVGFAWTIVLSFCVGLVLSSAFPAILLYAQELLPYK
HHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLISGLFFGFAFGVAGIASAVLGNMADHYGIEAVYNVCGFMPLLGLVTWFLPNLKKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVAPYGRTHIALFSILAFVAILVMIPICRWYKAYLSRVKWQKKSGETHVEMPLSLGKTVF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHH
SISILLTLIFSKYIYMASLNSYYTFYLIHKFGVSVQTSQICLFVFLIATAMGTLAGGPIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
DKIGRKYVIWGSILGAAPFSLLMPHVGFAWTIVLSFCVGLVLSSAFPAILLYAQELLPYK
HHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLISGLFFGFAFGVAGIASAVLGNMADHYGIEAVYNVCGFMPLLGLVTWFLPNLKKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]