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The map label for this gene is guaA

Identifier: 150006078

GI number: 150006078

Start: 4449723

End: 4451276

Strand: Direct

Name: guaA

Synonym: BVU_3587

Alternate gene names: 150006078

Gene position: 4449723-4451276 (Clockwise)

Preceding gene: 150006077

Following gene: 150006079

Centisome position: 86.18

GC content: 45.69

Gene sequence:

>1554_bases
ATGCAAGAAAAGATCATTATTCTCGACTTCGGTTCACAAACCACACAGCTCATAGCCCGTCGCGTTCGCGAACTGAATAC
TTATTGCGAGATTGTGCCTTACAACAAATTTCCACACAATGATCCGTCCATAATCGGCGTTATCCTTTCGGGAAGCCCTT
TCTCGGTGTATGATGAAAGCGCCTTTAAAGTCGATTTGAGTGACATTCGCGGAAAGTATCCTATTTTGGGTATCTGCTAT
GGTGCACAGTTCATGTCTTATACAAACGGTGGGAAAGTGGAACCGGCCGGCACACGTGAATACGGACGTGCACACCTTTC
CACTTTCGACCAAGAGAACCCACTATTGAAGAACGTCCGTGAACACTCACAAGTATGGATGAGCCACGGAGATACCATCA
CCGCCATTCCGGAGAATTTCAAAATTATCGCTTCAACAGATAAAGTAGCCATCGCTGCTTATCAAATAAAGGAAGAGAAA
GTATGGGGAGTACAGTTCCACCCGGAAGTGTTCCACAGTGAAGACGGAACCCAGCTTCTGAAAAATTTTGTAGTCGACAT
TTGCGGGGGGAAACAGGACTGGAGCGCTGCCTCTTTCATTGAAACGACTGTAGCCGAACTGAAAGCGCAACTGGGAAATG
ACAAAGTAGTACTGGGGCTGAGTGGCGGAGTAGACTCATCTGTGGCAGCCGTATTATTAAATAAAGCGATAGGCAAGAAT
CTTACCTGCATTTTTGTAGATCACGGCATGCTGCGTAAGAACGAATTCAAAAATGTACTCCATGATTATGAATGTCTCGG
ACTGAATGTAATCGGAGTGGATGCCAGCCAAAAATTCTTCAGTGAACTGGCAGGTGTGGAAGAACCTGAGAAGAAGCGTA
AGATTATCGGTAAAGGTTTTATTGACGTATTCGATGAAGAAGCTCATAAAATTAAAGATGTGAAATGGCTGGCACAAGGT
ACCATTTATCCTGACTGTATCGAGTCATTAAGTATCACCGGCACTGTAATCAAAAGTCATCACAACGTAGGTGGACTGCC
CGAAAAAATGAATTTGAAACTATGCGAGCCTCTGCGTCTGCTATTCAAGGATGAAGTACGCCACGTAGGTCGTGAACTGG
GTATGCCGGAACATCTGATTACACGCCATCCATTCCCCGGACCAGGACTTGCGGTACGTATTTTGGGTGATATCACTCCT
GAGAAAGTACGTATTCTGCAAGACGCCGATGATATCTATATCCAAGGATTGAGAGACTGGAAAGTGAAAGACTCGGACGG
AAACGAAACATCCCTTTACCACCAAGTATGGCAGGCAGGCGTAATCTTGCTACCCGTACAAAGTGTGGGAGTAATGGGGG
ACGAACGTACATACGAACGTGCCGTTGCCCTACGTGCCGTAACTAGTACGGATGCCATGACCGCCGACTGGGCTCATCTT
CCCTATGAATTTATGGCTAAGGTTTCAAACGACATAATCAATAAAGTAAAAGGTGTAAACCGCGTATGCTATGATATCTC
GTCCAAACCGCCTGCCACAATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TTTTCCAATTCAATTATAAAAAGCCTCAACAGCATGACGGATTTTTATTTTTTCTGAGTATCTTTGCGGCACGAAATCAT
TTACATATCTTAATATATAT

Downstream 100 bases:

>100_bases
TAGACAACCAACTAATAACTTAAAAACAACATAACGGAATGAAACAAGATATGATTGTTATCTTGGATTTGGGAAGCACC
GAAAACACCGTGCTTGCCAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MQEKIIILDFGSQTTQLIARRVRELNTYCEIVPYNKFPHNDPSIIGVILSGSPFSVYDESAFKVDLSDIRGKYPILGICY
GAQFMSYTNGGKVEPAGTREYGRAHLSTFDQENPLLKNVREHSQVWMSHGDTITAIPENFKIIASTDKVAIAAYQIKEEK
VWGVQFHPEVFHSEDGTQLLKNFVVDICGGKQDWSAASFIETTVAELKAQLGNDKVVLGLSGGVDSSVAAVLLNKAIGKN
LTCIFVDHGMLRKNEFKNVLHDYECLGLNVIGVDASQKFFSELAGVEEPEKKRKIIGKGFIDVFDEEAHKIKDVKWLAQG
TIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRLLFKDEVRHVGRELGMPEHLITRHPFPGPGLAVRILGDITP
EKVRILQDADDIYIQGLRDWKVKDSDGNETSLYHQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHL
PYEFMAKVSNDIINKVKGVNRVCYDISSKPPATIEWE

Sequences:

>Translated_517_residues
MQEKIIILDFGSQTTQLIARRVRELNTYCEIVPYNKFPHNDPSIIGVILSGSPFSVYDESAFKVDLSDIRGKYPILGICY
GAQFMSYTNGGKVEPAGTREYGRAHLSTFDQENPLLKNVREHSQVWMSHGDTITAIPENFKIIASTDKVAIAAYQIKEEK
VWGVQFHPEVFHSEDGTQLLKNFVVDICGGKQDWSAASFIETTVAELKAQLGNDKVVLGLSGGVDSSVAAVLLNKAIGKN
LTCIFVDHGMLRKNEFKNVLHDYECLGLNVIGVDASQKFFSELAGVEEPEKKRKIIGKGFIDVFDEEAHKIKDVKWLAQG
TIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRLLFKDEVRHVGRELGMPEHLITRHPFPGPGLAVRILGDITP
EKVRILQDADDIYIQGLRDWKVKDSDGNETSLYHQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHL
PYEFMAKVSNDIINKVKGVNRVCYDISSKPPATIEWE
>Mature_517_residues
MQEKIIILDFGSQTTQLIARRVRELNTYCEIVPYNKFPHNDPSIIGVILSGSPFSVYDESAFKVDLSDIRGKYPILGICY
GAQFMSYTNGGKVEPAGTREYGRAHLSTFDQENPLLKNVREHSQVWMSHGDTITAIPENFKIIASTDKVAIAAYQIKEEK
VWGVQFHPEVFHSEDGTQLLKNFVVDICGGKQDWSAASFIETTVAELKAQLGNDKVVLGLSGGVDSSVAAVLLNKAIGKN
LTCIFVDHGMLRKNEFKNVLHDYECLGLNVIGVDASQKFFSELAGVEEPEKKRKIIGKGFIDVFDEEAHKIKDVKWLAQG
TIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRLLFKDEVRHVGRELGMPEHLITRHPFPGPGLAVRILGDITP
EKVRILQDADDIYIQGLRDWKVKDSDGNETSLYHQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHL
PYEFMAKVSNDIINKVKGVNRVCYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=548, Percent_Identity=33.5766423357664, Blast_Score=272, Evalue=5e-73,
Organism=Escherichia coli, GI1788854, Length=531, Percent_Identity=51.6007532956685, Blast_Score=532, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71992710, Length=568, Percent_Identity=32.9225352112676, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI71992717, Length=568, Percent_Identity=32.9225352112676, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI133901714, Length=568, Percent_Identity=32.9225352112676, Blast_Score=270, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=50.0948766603416, Blast_Score=507, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6322638, Length=130, Percent_Identity=33.0769230769231, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=33.8181818181818, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_BACV8 (A6L686)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001300822.1
- ProteinModelPortal:   A6L686
- SMR:   A6L686
- STRING:   A6L686
- GeneID:   5304547
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3587
- NMPDR:   fig|435590.6.peg.3335
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   QDICGCE
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57643; Mature: 57643

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 79-79 ACT_SITE 167-167 ACT_SITE 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKIIILDFGSQTTQLIARRVRELNTYCEIVPYNKFPHNDPSIIGVILSGSPFSVYDES
CCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEECCC
AFKVDLSDIRGKYPILGICYGAQFMSYTNGGKVEPAGTREYGRAHLSTFDQENPLLKNVR
EEEEEHHHCCCCCCEEEEEECHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCHHHHHHH
EHSQVWMSHGDTITAIPENFKIIASTDKVAIAAYQIKEEKVWGVQFHPEVFHSEDGTQLL
HHHHHHHHCCCEEEECCCCCEEEEECCCEEEEEEEEECCEEEEEEECCHHHCCCCHHHHH
KNFVVDICGGKQDWSAASFIETTVAELKAQLGNDKVVLGLSGGVDSSVAAVLLNKAIGKN
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
LTCIFVDHGMLRKNEFKNVLHDYECLGLNVIGVDASQKFFSELAGVEEPEKKRKIIGKGF
EEEEEECCCCCCHHHHHHHHHCHHHCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCHH
IDVFDEEAHKIKDVKWLAQGTIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHH
LFKDEVRHVGRELGMPEHLITRHPFPGPGLAVRILGDITPEKVRILQDADDIYIQGLRDW
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEECCCCC
KVKDSDGNETSLYHQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHL
EEECCCCCCHHHHHHHHHCCEEEEEEHHHCCCCCCHHHHHHHHHHEECCCCCCCCCHHHC
PYEFMAKVSNDIINKVKGVNRVCYDISSKPPATIEWE
CHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEECC
>Mature Secondary Structure
MQEKIIILDFGSQTTQLIARRVRELNTYCEIVPYNKFPHNDPSIIGVILSGSPFSVYDES
CCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEECCC
AFKVDLSDIRGKYPILGICYGAQFMSYTNGGKVEPAGTREYGRAHLSTFDQENPLLKNVR
EEEEEHHHCCCCCCEEEEEECHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCHHHHHHH
EHSQVWMSHGDTITAIPENFKIIASTDKVAIAAYQIKEEKVWGVQFHPEVFHSEDGTQLL
HHHHHHHHCCCEEEECCCCCEEEEECCCEEEEEEEEECCEEEEEEECCHHHCCCCHHHHH
KNFVVDICGGKQDWSAASFIETTVAELKAQLGNDKVVLGLSGGVDSSVAAVLLNKAIGKN
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
LTCIFVDHGMLRKNEFKNVLHDYECLGLNVIGVDASQKFFSELAGVEEPEKKRKIIGKGF
EEEEEECCCCCCHHHHHHHHHCHHHCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCHH
IDVFDEEAHKIKDVKWLAQGTIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHH
LFKDEVRHVGRELGMPEHLITRHPFPGPGLAVRILGDITPEKVRILQDADDIYIQGLRDW
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEECCCCC
KVKDSDGNETSLYHQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHL
EEECCCCCCHHHHHHHHHCCEEEEEEHHHCCCCCCHHHHHHHHHHEECCCCCCCCCHHHC
PYEFMAKVSNDIINKVKGVNRVCYDISSKPPATIEWE
CHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA