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The map label for this gene is guaA2 [H]

Identifier: 150006079

GI number: 150006079

Start: 4451315

End: 4452622

Strand: Direct

Name: guaA2 [H]

Synonym: BVU_3588

Alternate gene names: 150006079

Gene position: 4451315-4452622 (Clockwise)

Preceding gene: 150006078

Following gene: 150006081

Centisome position: 86.21

GC content: 45.64

Gene sequence:

>1308_bases
ATGAAACAAGATATGATTGTTATCTTGGATTTGGGAAGCACCGAAAACACCGTGCTTGCCAGAGCCATTCGTGCTTTGGG
TGTATATAGTGAAATTTACCCGCACGATATCACAGCCGCCGAGCTGACAGCATTGCCCAATGTAAAGGGTGTCATTATCA
ATGGCGGTCCCAACCATGTAATTGACGGAGTGGATATTGACGTGCTTCCCGAGATTTACAAAGCAGGGATCCCCGTAATG
GCTGCCGGTCATGACAAAGCATGTTGCGAAGTGAAGCTTCCCCAACTGACGGATGATGTGGAAGCAATAAAGAATGCTGT
ACAATCGTTTGTTTTTGATACCTGCAAGGCAGAGGCTAACTGGAATATGACAAACTTTGTCAATGACCAGATTGAATTGA
TCCGCCGCCAGGTAGGCGACAAGAAAGTATTATTGGCACTTTCCGGAGGTGTAGACAGTTCTGTAGTAGCAGCTCTGTTG
CTGAAAGCCATCGGTAATAATCTGGTCTGCGTACATGTGAACCATGGATTAATGCGCAAAGGTGAATCGGAAGCAGTAAT
TGAAGTTTTCAAAAATCAGTTGAACGCTAATTTGATTTACGTGGATGCTACAGACCGTTTCCTGAGTAAACTGGAAAATG
TAGCTGATCCGGAGCAGAAACGCAAGATTATCGGTGGTGAATTTATTCGTGTGTTCGAAGAGGAAGCCCGTAAGCTAAAT
GGAATCGACTTTTTGGGACAAGGTACAATTTATCCTGATATCGTAGAAAGTGGTACTAAAACAGCCAAAATGGTTAAATC
CCATCACAATGTAGGTGGCTTACCCGAGGATTTACAGTTTGAATTAGTAGAACCTTTACGCCAGTTGTTCAAAGACGAAG
TCCGTGCCTGCGGAGTGGAACTTGGTTTACCATACGACATGGTCTACCGTCAGCCGTTCCCTGGTCCTGGTTTGGGAGTG
CGCTGTTTGGGGTCTATCACTCGTGACCGCCTGGAAGCTGTTCGCGAATCGGACGCCATCTTGCGTGAAGAATTCCAACT
GGCAGGCTTGGACAAGAAAGTATGGCAATATTTCACCGTAGTACCCGATTTCAAATCAGTAGGCGTGCGTGACAATGCCC
GTTCATTTGACTGGCCTGTTATTATCCGAGCTGTCAACACCGTAGATGCTATGACAGCTACTATCGAACCGATAGACTGG
TCCATTCTGATGAAAATTACCGACCGTATTCTAAAAGAAGTAAAGAATGTGAACCGCGTATGCTATGACCTGTCGCCCAA
ACCCAATGCGACCATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GTGTAAACCGCGTATGCTATGATATCTCGTCCAAACCGCCTGCCACAATTGAGTGGGAATAATAGACAACCAACTAATAA
CTTAAAAACAACATAACGGA

Downstream 100 bases:

>100_bases
AAAATATACTTCAAACCATGTAAGATCCCGAAACTAAAAGTTTCGGGATCTTTTTTATATTCAAGTTCTTCACTTTGCCC
CCAATGACACTAGAACAAGA

Product: putative GMP synthase

Products: NA

Alternate protein names: GMP synthetase 2; Glutamine amidotransferase 2 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKQDMIVILDLGSTENTVLARAIRALGVYSEIYPHDITAAELTALPNVKGVIINGGPNHVIDGVDIDVLPEIYKAGIPVM
AAGHDKACCEVKLPQLTDDVEAIKNAVQSFVFDTCKAEANWNMTNFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALL
LKAIGNNLVCVHVNHGLMRKGESEAVIEVFKNQLNANLIYVDATDRFLSKLENVADPEQKRKIIGGEFIRVFEEEARKLN
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVELGLPYDMVYRQPFPGPGLGV
RCLGSITRDRLEAVRESDAILREEFQLAGLDKKVWQYFTVVPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPIDW
SILMKITDRILKEVKNVNRVCYDLSPKPNATIEWE

Sequences:

>Translated_435_residues
MKQDMIVILDLGSTENTVLARAIRALGVYSEIYPHDITAAELTALPNVKGVIINGGPNHVIDGVDIDVLPEIYKAGIPVM
AAGHDKACCEVKLPQLTDDVEAIKNAVQSFVFDTCKAEANWNMTNFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALL
LKAIGNNLVCVHVNHGLMRKGESEAVIEVFKNQLNANLIYVDATDRFLSKLENVADPEQKRKIIGGEFIRVFEEEARKLN
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVELGLPYDMVYRQPFPGPGLGV
RCLGSITRDRLEAVRESDAILREEFQLAGLDKKVWQYFTVVPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPIDW
SILMKITDRILKEVKNVNRVCYDLSPKPNATIEWE
>Mature_435_residues
MKQDMIVILDLGSTENTVLARAIRALGVYSEIYPHDITAAELTALPNVKGVIINGGPNHVIDGVDIDVLPEIYKAGIPVM
AAGHDKACCEVKLPQLTDDVEAIKNAVQSFVFDTCKAEANWNMTNFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALL
LKAIGNNLVCVHVNHGLMRKGESEAVIEVFKNQLNANLIYVDATDRFLSKLENVADPEQKRKIIGGEFIRVFEEEARKLN
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVELGLPYDMVYRQPFPGPGLGV
RCLGSITRDRLEAVRESDAILREEFQLAGLDKKVWQYFTVVPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPIDW
SILMKITDRILKEVKNVNRVCYDLSPKPNATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=379, Percent_Identity=31.3984168865435, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1788854, Length=345, Percent_Identity=51.304347826087, Blast_Score=357, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI71992717, Length=386, Percent_Identity=32.9015544041451, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71992710, Length=386, Percent_Identity=32.9015544041451, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI133901714, Length=386, Percent_Identity=32.9015544041451, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323873, Length=350, Percent_Identity=45.1428571428571, Blast_Score=311, Evalue=1e-85,
Organism=Drosophila melanogaster, GI281365319, Length=372, Percent_Identity=32.5268817204301, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 48281; Mature: 48281

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDMIVILDLGSTENTVLARAIRALGVYSEIYPHDITAAELTALPNVKGVIINGGPNHV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCCCCE
IDGVDIDVLPEIYKAGIPVMAAGHDKACCEVKLPQLTDDVEAIKNAVQSFVFDTCKAEAN
ECCCCHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
WNMTNFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALLLKAIGNNLVCVHVNHGLMRK
CCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHCC
GESEAVIEVFKNQLNANLIYVDATDRFLSKLENVADPEQKRKIIGGEFIRVFEEEARKLN
CCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVE
CCCEECCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LGLPYDMVYRQPFPGPGLGVRCLGSITRDRLEAVRESDAILREEFQLAGLDKKVWQYFTV
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPIDWSILMKITDRILKEVKNVNRV
CCCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHE
CYDLSPKPNATIEWE
EEECCCCCCCEEECC
>Mature Secondary Structure
MKQDMIVILDLGSTENTVLARAIRALGVYSEIYPHDITAAELTALPNVKGVIINGGPNHV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCCCCE
IDGVDIDVLPEIYKAGIPVMAAGHDKACCEVKLPQLTDDVEAIKNAVQSFVFDTCKAEAN
ECCCCHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
WNMTNFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALLLKAIGNNLVCVHVNHGLMRK
CCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHCC
GESEAVIEVFKNQLNANLIYVDATDRFLSKLENVADPEQKRKIIGGEFIRVFEEEARKLN
CCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVE
CCCEECCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LGLPYDMVYRQPFPGPGLGVRCLGSITRDRLEAVRESDAILREEFQLAGLDKKVWQYFTV
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPIDWSILMKITDRILKEVKNVNRV
CCCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHE
CYDLSPKPNATIEWE
EEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]