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The map label for this gene is coaBC [H]

Identifier: 150005409

GI number: 150005409

Start: 3658438

End: 3659628

Strand: Reverse

Name: coaBC [H]

Synonym: BVU_2892

Alternate gene names: 150005409

Gene position: 3659628-3658438 (Counterclockwise)

Preceding gene: 150005410

Following gene: 150005408

Centisome position: 70.88

GC content: 46.52

Gene sequence:

>1191_bases
ATGAAAGGAAAAAAAATCGTACTAGGTATAACCGGAAGTATAGCCGCCTATAAAGCGGCTATACTCATTCGCGGACTTAT
TAAGAAGGGAGCGGAAGTACAAGTCGTGATTACCCCCGCAGGCAAAGAATTCATCACACCTATCACTTTGTCTGCATTAA
CAAGCAAACCTGTTATCAGCGAGTTTTTTGCCCAGCGTGACGGGACATGGAACAGCCACGTTGATTTGGGACTATGGGCG
GATGCCATGATTATCGCTCCGGCTACCGCATCCACTATTGGTAAAATGGCCAACGGAATAGCGGACAATATGCTGATCAC
GACTTATCTGTCAATGAAAGCTCCCGTATTCGTAGCTCCGGCAATGGATCTGGATATGTTCGCACACCCTTCCACCCGGA
AGAATCTGGACACGCTCCGTTCTTACGGAAATCATATTATAGAACCGGCAGAAGGGGAACTGGCAAGCCATCTGGTAGGA
AAAGGCAGAATGGAAGAACCGGAAAAAATAGTGGAAATTCTGGAAGCTTTCTTTGCCAAACAACAAGACATGGCCGGAAA
GAAAGTAGTCATTACCGCCGGTCCAACCTACGAGAAAATAGATCCGGTACGCTTTATCGGCAATTATTCTTCAGGAAAAA
TGGGATTCGCACTTGCCGAGGAATGCGCTTCACGTGGAGCGGAAGTATCGCTAATCAGCGGACCGGTAACGATTCAGGCC
CATCACCCTAACATCCGCCGCATAGATGTGGAAAGTGCCGGAGAAATGTACGAAGCCGCCATCCGCGAGTTTCCTACAGC
TTCGGCCGGCATCCTGTGTGCGGCAGTGGCCGACTTTACCCCGGAAACCGTAGCCGGTCATAAAATCAAAAGAGAGAAAG
ATAATTTAATACTGCAATTGAAACCCACACAAGACATTGCCGCCGCACTGGGAAACCGGAAAAAAGACGGACAGACATTA
GTGGGATTTGCCTTGGAAACAAATGATGAAACAAAAAATGCACAAAGAAAACTGGAACGTAAGAACCTTGATTTCATTGT
ACTGAACTCATTGAACGACCAAGGAGCCGGGTTTCGTTGTGACACCAACAAAATAACGATTATAGACCGTCAGGGAGCAA
CTCCTTATCCGCTGAAAAGCAAACAGGAAGTAGCAAGGGATATTATTGACAGACTGGTAAATAATAAATAA

Upstream 100 bases:

>100_bases
CGGGCTACTACAGCTGGATACTGAACGGTGACTTTACGCTGAACACGAAAAACGTACTGACAAAAATCAGACTACGTGAA
TCGGGAATGATGAAATGAGT

Downstream 100 bases:

>100_bases
TTTCTTAATTTGCCATGTTGCCAATGTGCCAATGTGCTAATGTGCTAATGTGCTAATTACCATGCGGAATACAACAGCGC
AGCAAATTAGCAAATTGACA

Product: flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKGKKIVLGITGSIAAYKAAILIRGLIKKGAEVQVVITPAGKEFITPITLSALTSKPVISEFFAQRDGTWNSHVDLGLWA
DAMIIAPATASTIGKMANGIADNMLITTYLSMKAPVFVAPAMDLDMFAHPSTRKNLDTLRSYGNHIIEPAEGELASHLVG
KGRMEEPEKIVEILEAFFAKQQDMAGKKVVITAGPTYEKIDPVRFIGNYSSGKMGFALAEECASRGAEVSLISGPVTIQA
HHPNIRRIDVESAGEMYEAAIREFPTASAGILCAAVADFTPETVAGHKIKREKDNLILQLKPTQDIAAALGNRKKDGQTL
VGFALETNDETKNAQRKLERKNLDFIVLNSLNDQGAGFRCDTNKITIIDRQGATPYPLKSKQEVARDIIDRLVNNK

Sequences:

>Translated_396_residues
MKGKKIVLGITGSIAAYKAAILIRGLIKKGAEVQVVITPAGKEFITPITLSALTSKPVISEFFAQRDGTWNSHVDLGLWA
DAMIIAPATASTIGKMANGIADNMLITTYLSMKAPVFVAPAMDLDMFAHPSTRKNLDTLRSYGNHIIEPAEGELASHLVG
KGRMEEPEKIVEILEAFFAKQQDMAGKKVVITAGPTYEKIDPVRFIGNYSSGKMGFALAEECASRGAEVSLISGPVTIQA
HHPNIRRIDVESAGEMYEAAIREFPTASAGILCAAVADFTPETVAGHKIKREKDNLILQLKPTQDIAAALGNRKKDGQTL
VGFALETNDETKNAQRKLERKNLDFIVLNSLNDQGAGFRCDTNKITIIDRQGATPYPLKSKQEVARDIIDRLVNNK
>Mature_396_residues
MKGKKIVLGITGSIAAYKAAILIRGLIKKGAEVQVVITPAGKEFITPITLSALTSKPVISEFFAQRDGTWNSHVDLGLWA
DAMIIAPATASTIGKMANGIADNMLITTYLSMKAPVFVAPAMDLDMFAHPSTRKNLDTLRSYGNHIIEPAEGELASHLVG
KGRMEEPEKIVEILEAFFAKQQDMAGKKVVITAGPTYEKIDPVRFIGNYSSGKMGFALAEECASRGAEVSLISGPVTIQA
HHPNIRRIDVESAGEMYEAAIREFPTASAGILCAAVADFTPETVAGHKIKREKDNLILQLKPTQDIAAALGNRKKDGQTL
VGFALETNDETKNAQRKLERKNLDFIVLNSLNDQGAGFRCDTNKITIIDRQGATPYPLKSKQEVARDIIDRLVNNK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=33.879781420765, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=40.9090909090909, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17560194, Length=188, Percent_Identity=30.8510638297872, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=31.7204301075269, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=35.978835978836, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42958; Mature: 42958

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKKIVLGITGSIAAYKAAILIRGLIKKGAEVQVVITPAGKEFITPITLSALTSKPVIS
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEHHHHCCCHHHH
EFFAQRDGTWNSHVDLGLWADAMIIAPATASTIGKMANGIADNMLITTYLSMKAPVFVAP
HHHHHCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHCCHHEEEHHHCCCCEEEEC
AMDLDMFAHPSTRKNLDTLRSYGNHIIEPAEGELASHLVGKGRMEEPEKIVEILEAFFAK
CCCCHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QQDMAGKKVVITAGPTYEKIDPVRFIGNYSSGKMGFALAEECASRGAEVSLISGPVTIQA
HHCCCCCEEEEECCCCCHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCEEEEE
HHPNIRRIDVESAGEMYEAAIREFPTASAGILCAAVADFTPETVAGHKIKREKDNLILQL
CCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHCCCCCCCCCCCEEEEE
KPTQDIAAALGNRKKDGQTLVGFALETNDETKNAQRKLERKNLDFIVLNSLNDQGAGFRC
ECCHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEE
DTNKITIIDRQGATPYPLKSKQEVARDIIDRLVNNK
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGKKIVLGITGSIAAYKAAILIRGLIKKGAEVQVVITPAGKEFITPITLSALTSKPVIS
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEHHHHCCCHHHH
EFFAQRDGTWNSHVDLGLWADAMIIAPATASTIGKMANGIADNMLITTYLSMKAPVFVAP
HHHHHCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHCCHHEEEHHHCCCCEEEEC
AMDLDMFAHPSTRKNLDTLRSYGNHIIEPAEGELASHLVGKGRMEEPEKIVEILEAFFAK
CCCCHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QQDMAGKKVVITAGPTYEKIDPVRFIGNYSSGKMGFALAEECASRGAEVSLISGPVTIQA
HHCCCCCEEEEECCCCCHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCEEEEE
HHPNIRRIDVESAGEMYEAAIREFPTASAGILCAAVADFTPETVAGHKIKREKDNLILQL
CCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHCCCCCCCCCCCEEEEE
KPTQDIAAALGNRKKDGQTLVGFALETNDETKNAQRKLERKNLDFIVLNSLNDQGAGFRC
ECCHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEE
DTNKITIIDRQGATPYPLKSKQEVARDIIDRLVNNK
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]